Expression and prognostic value of CLIC1 in epithelial ovarian cancer
The clinical significance of the chloride intracellular channel 1 (CLIC1) protein in ovarian cancer is yet to be determined. The present study aimed to investigate the association between CLIC1 expression, and clinicopathological features and prognosis of patients with epithelial ovarian cancer. In...
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| Veröffentlicht in: | Experimental and therapeutic medicine 2018-06, Vol.15 (6), p.4943-4949 |
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| creator | Yu, Wentao Cui, Ran Qu, Hong Liu, Chongdong Deng, Haiteng Zhang, Zhenyu |
| description | The clinical significance of the chloride intracellular channel 1 (CLIC1) protein in ovarian cancer is yet to be determined. The present study aimed to investigate the association between CLIC1 expression, and clinicopathological features and prognosis of patients with epithelial ovarian cancer. In this retrospective study, CLIC1 level was determined by reverse transcription-quantitative polymerase chain reaction, western blotting and immunohistochemical staining. The association between CLIC1 expression and clinicopathological characteristics were evaluated. Progression-free survival and overall survival were assessed by univariate, and multivariate analyses. mRNA and protein levels of
were significantly higher in cancerous tissues than in healthy ovarian tissues (P |
| doi_str_mv | 10.3892/etm.2018.6000 |
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were significantly higher in cancerous tissues than in healthy ovarian tissues (P<0.001). CLIC1 signals in epithelial ovarian cancer tissues were significantly higher than that in healthy tissues (P<0.001). CLIC1 expression was significantly higher in higher-grade tumors than in low-grade tumors (P<0.001). Moreover, overexpression of CLIC1 was associated with cisplatin resistance (P<0.001). CLIC1 expression was an independent factor that predicted shorter progression-free survival (P=0.006) and overall survival (P=0.002) for patients with epithelial ovarian cancer. These findings indicate that CLIC1 is overexpressed and is associated with poor prognosis in patients with epithelial ovarian cancer.</description><identifier>ISSN: 1792-0981</identifier><identifier>EISSN: 1792-1015</identifier><identifier>DOI: 10.3892/etm.2018.6000</identifier><identifier>PMID: 29805518</identifier><language>eng</language><publisher>Greece: Spandidos Publications</publisher><subject>Age ; Antigens ; Apoptosis ; Cancer genetics ; Cancer research ; Cancer therapies ; Cell cycle ; Cell division ; Cell growth ; Chemotherapy ; Chloride channels ; Development and progression ; Gynecology ; Health aspects ; Hospitals ; Medical prognosis ; Medical screening ; Obstetrics ; Ovarian cancer ; Physiological aspects ; Prognosis ; Proteins ; Tumors</subject><ispartof>Experimental and therapeutic medicine, 2018-06, Vol.15 (6), p.4943-4949</ispartof><rights>COPYRIGHT 2018 Spandidos Publications</rights><rights>Copyright Spandidos Publications UK Ltd. 2018</rights><rights>Copyright: © Yu et al. 2018</rights><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c482t-6ef2b46c8a59520e7cd7e98e54041d586ed8786b231e084366585902994679283</citedby><cites>FETCH-LOGICAL-c482t-6ef2b46c8a59520e7cd7e98e54041d586ed8786b231e084366585902994679283</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5952105/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5952105/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,885,27924,27925,53791,53793</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/29805518$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Yu, Wentao</creatorcontrib><creatorcontrib>Cui, Ran</creatorcontrib><creatorcontrib>Qu, Hong</creatorcontrib><creatorcontrib>Liu, Chongdong</creatorcontrib><creatorcontrib>Deng, Haiteng</creatorcontrib><creatorcontrib>Zhang, Zhenyu</creatorcontrib><title>Expression and prognostic value of CLIC1 in epithelial ovarian cancer</title><title>Experimental and therapeutic medicine</title><addtitle>Exp Ther Med</addtitle><description>The clinical significance of the chloride intracellular channel 1 (CLIC1) protein in ovarian cancer is yet to be determined. The present study aimed to investigate the association between CLIC1 expression, and clinicopathological features and prognosis of patients with epithelial ovarian cancer. In this retrospective study, CLIC1 level was determined by reverse transcription-quantitative polymerase chain reaction, western blotting and immunohistochemical staining. The association between CLIC1 expression and clinicopathological characteristics were evaluated. Progression-free survival and overall survival were assessed by univariate, and multivariate analyses. mRNA and protein levels of
were significantly higher in cancerous tissues than in healthy ovarian tissues (P<0.001). CLIC1 signals in epithelial ovarian cancer tissues were significantly higher than that in healthy tissues (P<0.001). CLIC1 expression was significantly higher in higher-grade tumors than in low-grade tumors (P<0.001). Moreover, overexpression of CLIC1 was associated with cisplatin resistance (P<0.001). CLIC1 expression was an independent factor that predicted shorter progression-free survival (P=0.006) and overall survival (P=0.002) for patients with epithelial ovarian cancer. These findings indicate that CLIC1 is overexpressed and is associated with poor prognosis in patients with epithelial ovarian cancer.</description><subject>Age</subject><subject>Antigens</subject><subject>Apoptosis</subject><subject>Cancer genetics</subject><subject>Cancer research</subject><subject>Cancer therapies</subject><subject>Cell cycle</subject><subject>Cell division</subject><subject>Cell growth</subject><subject>Chemotherapy</subject><subject>Chloride channels</subject><subject>Development and progression</subject><subject>Gynecology</subject><subject>Health aspects</subject><subject>Hospitals</subject><subject>Medical prognosis</subject><subject>Medical screening</subject><subject>Obstetrics</subject><subject>Ovarian cancer</subject><subject>Physiological aspects</subject><subject>Prognosis</subject><subject>Proteins</subject><subject>Tumors</subject><issn>1792-0981</issn><issn>1792-1015</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><recordid>eNptkcGL1DAUxoso7rLu0asEvHjpmKRJ-nIRlmHUhQEveg6Z9HU2S5vUpB30vzdlx9UVyeGFvN_7Hl--qnrN6KYBzd_jPG44ZbBRlNJn1SVrNa8ZZfL5-U41sIvqOuf7AlCpGIB8WV1wDVRKBpfVbvdjSpizj4HY0JEpxWOIefaOnOywIIk92e5vt4z4QHDy8x0O3g4knmzyNhBng8P0qnrR2yHj9bleVd8-7r5uP9f7L59utzf72gngc62w5wehHFipJafYuq5FDSgFFayToLCDFtSBNwwpiEYpCVJTrrVQxQ00V9WHB91pOYzYOQxzsoOZkh9t-mmi9eZpJ_g7c4wns-5jVBaBd2eBFL8vmGcz-uxwGGzAuGTDqVCUU67agr79B72PSwrFXqG0FJwLkH-oox3Q-NDHstetouZGSg5CCKULtfkPVU6Ho3cxYO_L-5OB-mHApZhzwv7RI6Nmjd6U6M0avVmjL_ybvz_mkf4ddPMLBfWmDg</recordid><startdate>20180601</startdate><enddate>20180601</enddate><creator>Yu, Wentao</creator><creator>Cui, Ran</creator><creator>Qu, Hong</creator><creator>Liu, Chongdong</creator><creator>Deng, Haiteng</creator><creator>Zhang, Zhenyu</creator><general>Spandidos Publications</general><general>Spandidos Publications UK Ltd</general><general>D.A. Spandidos</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7RV</scope><scope>7X7</scope><scope>7XB</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AN0</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>KB0</scope><scope>M0S</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20180601</creationdate><title>Expression and prognostic value of CLIC1 in epithelial ovarian cancer</title><author>Yu, Wentao ; Cui, Ran ; Qu, Hong ; Liu, Chongdong ; Deng, Haiteng ; Zhang, Zhenyu</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c482t-6ef2b46c8a59520e7cd7e98e54041d586ed8786b231e084366585902994679283</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2018</creationdate><topic>Age</topic><topic>Antigens</topic><topic>Apoptosis</topic><topic>Cancer genetics</topic><topic>Cancer research</topic><topic>Cancer therapies</topic><topic>Cell cycle</topic><topic>Cell division</topic><topic>Cell growth</topic><topic>Chemotherapy</topic><topic>Chloride channels</topic><topic>Development and progression</topic><topic>Gynecology</topic><topic>Health aspects</topic><topic>Hospitals</topic><topic>Medical prognosis</topic><topic>Medical screening</topic><topic>Obstetrics</topic><topic>Ovarian cancer</topic><topic>Physiological aspects</topic><topic>Prognosis</topic><topic>Proteins</topic><topic>Tumors</topic><toplevel>online_resources</toplevel><creatorcontrib>Yu, Wentao</creatorcontrib><creatorcontrib>Cui, Ran</creatorcontrib><creatorcontrib>Qu, Hong</creatorcontrib><creatorcontrib>Liu, Chongdong</creatorcontrib><creatorcontrib>Deng, Haiteng</creatorcontrib><creatorcontrib>Zhang, Zhenyu</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>ProQuest Nursing and Allied Health Source</collection><collection>ProQuest Health and Medical</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni)</collection><collection>ProQuest Central UK/Ireland</collection><collection>British Nursing Database</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Experimental and therapeutic medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Yu, Wentao</au><au>Cui, Ran</au><au>Qu, Hong</au><au>Liu, Chongdong</au><au>Deng, Haiteng</au><au>Zhang, Zhenyu</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Expression and prognostic value of CLIC1 in epithelial ovarian cancer</atitle><jtitle>Experimental and therapeutic medicine</jtitle><addtitle>Exp Ther Med</addtitle><date>2018-06-01</date><risdate>2018</risdate><volume>15</volume><issue>6</issue><spage>4943</spage><epage>4949</epage><pages>4943-4949</pages><issn>1792-0981</issn><eissn>1792-1015</eissn><abstract>The clinical significance of the chloride intracellular channel 1 (CLIC1) protein in ovarian cancer is yet to be determined. The present study aimed to investigate the association between CLIC1 expression, and clinicopathological features and prognosis of patients with epithelial ovarian cancer. In this retrospective study, CLIC1 level was determined by reverse transcription-quantitative polymerase chain reaction, western blotting and immunohistochemical staining. The association between CLIC1 expression and clinicopathological characteristics were evaluated. Progression-free survival and overall survival were assessed by univariate, and multivariate analyses. mRNA and protein levels of
were significantly higher in cancerous tissues than in healthy ovarian tissues (P<0.001). CLIC1 signals in epithelial ovarian cancer tissues were significantly higher than that in healthy tissues (P<0.001). CLIC1 expression was significantly higher in higher-grade tumors than in low-grade tumors (P<0.001). Moreover, overexpression of CLIC1 was associated with cisplatin resistance (P<0.001). CLIC1 expression was an independent factor that predicted shorter progression-free survival (P=0.006) and overall survival (P=0.002) for patients with epithelial ovarian cancer. These findings indicate that CLIC1 is overexpressed and is associated with poor prognosis in patients with epithelial ovarian cancer.</abstract><cop>Greece</cop><pub>Spandidos Publications</pub><pmid>29805518</pmid><doi>10.3892/etm.2018.6000</doi><tpages>7</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Age Antigens Apoptosis Cancer genetics Cancer research Cancer therapies Cell cycle Cell division Cell growth Chemotherapy Chloride channels Development and progression Gynecology Health aspects Hospitals Medical prognosis Medical screening Obstetrics Ovarian cancer Physiological aspects Prognosis Proteins Tumors |
| title | Expression and prognostic value of CLIC1 in epithelial ovarian cancer |
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