The therapeutic effects of bee venom on some metabolic and antioxidant parameters associated with HFD-induced non-alcoholic fatty liver in rats
The present study was designed to investigate the therapeutic effects of bee venom (BV) on high-fat diet (HFD)-induced non-alcoholic fatty liver (NAFL) in rats at different levels. Histological manifestations, hepatic lipid content, liver function tests, glucose homeostasis, lipid abnormalities, adi...
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| Veröffentlicht in: | Experimental and therapeutic medicine 2018-06, Vol.15 (6), p.5091-5099 |
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| creator | Hanafi, Mervat Y Zaher, Eman L M El-Adely, Soha E M Sakr, Ahmed Ghobashi, Ahmed H M Hemly, Madiha H Kazem, Amani H Kamel, Maher A |
| description | The present study was designed to investigate the therapeutic effects of bee venom (BV) on high-fat diet (HFD)-induced non-alcoholic fatty liver (NAFL) in rats at different levels. Histological manifestations, hepatic lipid content, liver function tests, glucose homeostasis, lipid abnormalities, adipocytokines, lipid peroxidation, disturbed glutathione and antioxidant enzymes systems and dysregulation of Nrf2 transcription factor were assessed. In the present study, the NAFL rats were subcutaneously treated with BV with different doses (0.01, 0.05, 0.1 mg/kg). The results indicated that BV treatment completely normalized the lipid profile values of NAFL rats. Fasting blood sugar, insulin level and homeostatic model assessment of insulin resistance significantly decreased. BV treated rats showed a significantly lower level of all liver enzymes and bilirubin. Moreover, BV treatment significantly increased the levels of active nuclear erythroid factor 2 like 2, glutathione (GSH) (total and reduced), GSH/glutathione disulphide ratio and activities of glutathione reductase, glutathione-S-transferase and glutathione peroxidase (total and Se-dependent). The level of tumor necrosis factor-α was reduced. Treatment showed correction of adiponectin level, and significant downregulation of hepatic triglycerides and cholesterol. At the histological level, BV improved the architecture of liver cells showing normal sinusoids. It may be concluded that BV may represent an interesting therapeutic alternative for the treatment of NAFL disease. |
| doi_str_mv | 10.3892/etm.2018.6028 |
| format | Article |
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Histological manifestations, hepatic lipid content, liver function tests, glucose homeostasis, lipid abnormalities, adipocytokines, lipid peroxidation, disturbed glutathione and antioxidant enzymes systems and dysregulation of Nrf2 transcription factor were assessed. In the present study, the NAFL rats were subcutaneously treated with BV with different doses (0.01, 0.05, 0.1 mg/kg). The results indicated that BV treatment completely normalized the lipid profile values of NAFL rats. Fasting blood sugar, insulin level and homeostatic model assessment of insulin resistance significantly decreased. BV treated rats showed a significantly lower level of all liver enzymes and bilirubin. Moreover, BV treatment significantly increased the levels of active nuclear erythroid factor 2 like 2, glutathione (GSH) (total and reduced), GSH/glutathione disulphide ratio and activities of glutathione reductase, glutathione-S-transferase and glutathione peroxidase (total and Se-dependent). The level of tumor necrosis factor-α was reduced. Treatment showed correction of adiponectin level, and significant downregulation of hepatic triglycerides and cholesterol. At the histological level, BV improved the architecture of liver cells showing normal sinusoids. It may be concluded that BV may represent an interesting therapeutic alternative for the treatment of NAFL disease.</description><identifier>ISSN: 1792-0981</identifier><identifier>EISSN: 1792-1015</identifier><identifier>DOI: 10.3892/etm.2018.6028</identifier><identifier>PMID: 29805535</identifier><language>eng</language><publisher>Greece: Spandidos Publications</publisher><subject>Antioxidants ; Care and treatment ; Cholesterol ; Development and progression ; Fasting ; Fatty liver ; Health aspects ; High fat diet ; Homeostasis ; Insulin resistance ; Laboratory animals ; Lipid peroxidation ; Lipids ; Liver ; Medical research ; Metabolic disorders ; Metabolism ; Methods ; Oxidative stress ; Pathogenesis ; Patient outcomes ; Rodents ; Tumor necrosis factor-TNF ; Variance analysis ; Venom immunotherapy</subject><ispartof>Experimental and therapeutic medicine, 2018-06, Vol.15 (6), p.5091-5099</ispartof><rights>COPYRIGHT 2018 Spandidos Publications</rights><rights>Copyright Spandidos Publications UK Ltd. 2018</rights><rights>Copyright © 2018, Spandidos Publications 2018</rights><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c482t-dc603e027f54b9e64edae735852c98d15fabba9f608a801980ab7f56f014f03b3</citedby><cites>FETCH-LOGICAL-c482t-dc603e027f54b9e64edae735852c98d15fabba9f608a801980ab7f56f014f03b3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5952098/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5952098/$$EHTML$$P50$$Gpubmedcentral$$H</linktohtml><link.rule.ids>230,314,727,780,784,885,27924,27925,53791,53793</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/29805535$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Hanafi, Mervat Y</creatorcontrib><creatorcontrib>Zaher, Eman L M</creatorcontrib><creatorcontrib>El-Adely, Soha E M</creatorcontrib><creatorcontrib>Sakr, Ahmed</creatorcontrib><creatorcontrib>Ghobashi, Ahmed H M</creatorcontrib><creatorcontrib>Hemly, Madiha H</creatorcontrib><creatorcontrib>Kazem, Amani H</creatorcontrib><creatorcontrib>Kamel, Maher A</creatorcontrib><title>The therapeutic effects of bee venom on some metabolic and antioxidant parameters associated with HFD-induced non-alcoholic fatty liver in rats</title><title>Experimental and therapeutic medicine</title><addtitle>Exp Ther Med</addtitle><description>The present study was designed to investigate the therapeutic effects of bee venom (BV) on high-fat diet (HFD)-induced non-alcoholic fatty liver (NAFL) in rats at different levels. Histological manifestations, hepatic lipid content, liver function tests, glucose homeostasis, lipid abnormalities, adipocytokines, lipid peroxidation, disturbed glutathione and antioxidant enzymes systems and dysregulation of Nrf2 transcription factor were assessed. In the present study, the NAFL rats were subcutaneously treated with BV with different doses (0.01, 0.05, 0.1 mg/kg). The results indicated that BV treatment completely normalized the lipid profile values of NAFL rats. Fasting blood sugar, insulin level and homeostatic model assessment of insulin resistance significantly decreased. BV treated rats showed a significantly lower level of all liver enzymes and bilirubin. Moreover, BV treatment significantly increased the levels of active nuclear erythroid factor 2 like 2, glutathione (GSH) (total and reduced), GSH/glutathione disulphide ratio and activities of glutathione reductase, glutathione-S-transferase and glutathione peroxidase (total and Se-dependent). The level of tumor necrosis factor-α was reduced. Treatment showed correction of adiponectin level, and significant downregulation of hepatic triglycerides and cholesterol. At the histological level, BV improved the architecture of liver cells showing normal sinusoids. It may be concluded that BV may represent an interesting therapeutic alternative for the treatment of NAFL disease.</description><subject>Antioxidants</subject><subject>Care and treatment</subject><subject>Cholesterol</subject><subject>Development and progression</subject><subject>Fasting</subject><subject>Fatty liver</subject><subject>Health aspects</subject><subject>High fat diet</subject><subject>Homeostasis</subject><subject>Insulin resistance</subject><subject>Laboratory animals</subject><subject>Lipid peroxidation</subject><subject>Lipids</subject><subject>Liver</subject><subject>Medical research</subject><subject>Metabolic disorders</subject><subject>Metabolism</subject><subject>Methods</subject><subject>Oxidative stress</subject><subject>Pathogenesis</subject><subject>Patient outcomes</subject><subject>Rodents</subject><subject>Tumor necrosis factor-TNF</subject><subject>Variance analysis</subject><subject>Venom immunotherapy</subject><issn>1792-0981</issn><issn>1792-1015</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><recordid>eNptkkFvFSEQxzdGY5vao1dD4sXLPoGFfXAxaaq1Jk281DOZZYc-ml14Avu0n8KvLM8-qzVCCGTmx38yk3_TvGR01SnN32KZV5wyteopV0-aY7bWvGWUyaeHN9WKHTWnOd_SumTPlJLPmyOuFZWyk8fNj-sNkrLBBFtcircEnUNbMomODIhkhyHOJAaS44xkxgJDnCoGYayn-Pjdj_UmW0hQs5gygZyj9VBwJN982ZDLi_etD-NiayDE0MJk4-aXiINS7sjkd5iIDyRByS-aZw6mjKeH-6T5cvHh-vyyvfr88dP52VVrheKlHW1PO6R87aQYNPYCR8B1J5XkVquRSQfDANr1VIGirLYLQ2V7R5lwtBu6k-bdve52GWYcLYaSYDLb5GdIdyaCN48zwW_MTdwZqSWvU60Cbw4CKX5dMBcz-2xxmiBgXLLhVPS1mO5FRV__g97GJYXaXqW0FB3jvfpD3cCExgcXa127FzVnUnIlhNC0Uqv_UHWPOHsbAzpf448-tPcfbIo5J3QPPTJq9iYy1URmbyKzN1HlX_09mAf6t2W6n9RIw-Y</recordid><startdate>20180601</startdate><enddate>20180601</enddate><creator>Hanafi, Mervat Y</creator><creator>Zaher, Eman L M</creator><creator>El-Adely, Soha E M</creator><creator>Sakr, Ahmed</creator><creator>Ghobashi, Ahmed H M</creator><creator>Hemly, Madiha H</creator><creator>Kazem, Amani H</creator><creator>Kamel, Maher A</creator><general>Spandidos Publications</general><general>Spandidos Publications UK Ltd</general><general>D.A. 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Histological manifestations, hepatic lipid content, liver function tests, glucose homeostasis, lipid abnormalities, adipocytokines, lipid peroxidation, disturbed glutathione and antioxidant enzymes systems and dysregulation of Nrf2 transcription factor were assessed. In the present study, the NAFL rats were subcutaneously treated with BV with different doses (0.01, 0.05, 0.1 mg/kg). The results indicated that BV treatment completely normalized the lipid profile values of NAFL rats. Fasting blood sugar, insulin level and homeostatic model assessment of insulin resistance significantly decreased. BV treated rats showed a significantly lower level of all liver enzymes and bilirubin. Moreover, BV treatment significantly increased the levels of active nuclear erythroid factor 2 like 2, glutathione (GSH) (total and reduced), GSH/glutathione disulphide ratio and activities of glutathione reductase, glutathione-S-transferase and glutathione peroxidase (total and Se-dependent). The level of tumor necrosis factor-α was reduced. Treatment showed correction of adiponectin level, and significant downregulation of hepatic triglycerides and cholesterol. At the histological level, BV improved the architecture of liver cells showing normal sinusoids. It may be concluded that BV may represent an interesting therapeutic alternative for the treatment of NAFL disease.</abstract><cop>Greece</cop><pub>Spandidos Publications</pub><pmid>29805535</pmid><doi>10.3892/etm.2018.6028</doi><tpages>9</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Antioxidants Care and treatment Cholesterol Development and progression Fasting Fatty liver Health aspects High fat diet Homeostasis Insulin resistance Laboratory animals Lipid peroxidation Lipids Liver Medical research Metabolic disorders Metabolism Methods Oxidative stress Pathogenesis Patient outcomes Rodents Tumor necrosis factor-TNF Variance analysis Venom immunotherapy |
| title | The therapeutic effects of bee venom on some metabolic and antioxidant parameters associated with HFD-induced non-alcoholic fatty liver in rats |
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