An NF90/NF110-mediated feedback amplification loop regulates dicer expression and controls ovarian carcinoma progression

Reduced expression of DICER, a key enzyme in the miRNA pathway, is frequently associated with aggressive, invasive disease, and poor survival in various malignancies. Regulation of DICER expression is, however, poorly understood. Here, we show that NF90/NF110 facilitates DICER expression by controll...

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Veröffentlicht in:	Cell research 2018-05, Vol.28 (5), p.556-571
Hauptverfasser:	Barbier, Jérôme, Chen, Xin, Sanchez, Gabriel, Cai, Muyan, Helsmoortel, Marion, Higuchi, Takuma, Giraud, Pierre, Contreras, Xavier, Yuan, Gangjun, Feng, Zihao, Nait-Saidi, Rima, Deas, Olivier, Bluy, Lisa, Judde, Jean-Gabriel, Rouquier, Sylvie, Ritchie, William, Sakamoto, Shuji, Xie, Dan, Kiernan, Rosemary
Format:	Artikel
Sprache:	eng
Schlagworte:	38/109 38/71 38/89 38/90 631/337/384/331 631/67/1517/1709 64/60 82/51 82/80 Amplification Animals Base Sequence Biomedical and Life Sciences Cell Biology Cell Line, Tumor Cell Movement Cell proliferation Disease Progression Feedback Feedback, Physiological Female Genetics HEK293 Cells Humans Invasiveness Life Sciences Metastases Metastasis Mice, Inbred BALB C Mice, Nude MicroRNAs - genetics MicroRNAs - metabolism miRNA Models, Biological mRNA Neoplasm Metastasis Nuclear Factor 90 Proteins - metabolism Ovarian cancer Ovarian carcinoma Ovarian Neoplasms - genetics Ovarian Neoplasms - pathology Ribonuclease III - genetics Ribonuclease III - metabolism RNA Precursors - genetics RNA Precursors - metabolism RNA Splicing - genetics Survival Treatment Outcome
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