Microglia contribute to normal myelinogenesis and to oligodendrocyte progenitor maintenance during adulthood
Whereas microglia involvement in virtually all brain diseases is well accepted their role in the control of homeostasis in the central nervous system (CNS) is mainly thought to be the maintenance of neuronal function through the formation, refinement, and monitoring of synapses in both the developin...
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| Veröffentlicht in: | Acta neuropathologica 2017-09, Vol.134 (3), p.441-458 |
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| container_title | Acta neuropathologica |
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| creator | Hagemeyer, Nora Hanft, Klara-Maria Akriditou, Maria-Anna Unger, Nicole Park, Eun S. Stanley, E. Richard Staszewski, Ori Dimou, Leda Prinz, Marco |
| description | Whereas microglia involvement in virtually all brain diseases is well accepted their role in the control of homeostasis in the central nervous system (CNS) is mainly thought to be the maintenance of neuronal function through the formation, refinement, and monitoring of synapses in both the developing and adult brain. Although the prenatal origin as well as the neuron-centered function of cortical microglia has recently been elucidated, much less is known about a distinct amoeboid microglia population formerly described as the “fountain of microglia” that appears only postnatally in myelinated regions such as corpus callosum and cerebellum. Using large-scale transcriptional profiling, fate mapping, and genetic targeting approaches, we identified a unique molecular signature of this microglia subset that arose from a CNS endogenous microglia pool independent from circulating myeloid cells. Microglia depletion experiments revealed an essential role of postnatal microglia for the proper development and homeostasis of oligodendrocytes and their progenitors. Our data provide new cellular and molecular insights into the myelin-supporting function of microglia in the normal CNS. |
| doi_str_mv | 10.1007/s00401-017-1747-1 |
| format | Article |
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Using large-scale transcriptional profiling, fate mapping, and genetic targeting approaches, we identified a unique molecular signature of this microglia subset that arose from a CNS endogenous microglia pool independent from circulating myeloid cells. Microglia depletion experiments revealed an essential role of postnatal microglia for the proper development and homeostasis of oligodendrocytes and their progenitors. 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Our data provide new cellular and molecular insights into the myelin-supporting function of microglia in the normal CNS.</description><subject>Animals</subject><subject>Brain</subject><subject>Brain mapping</subject><subject>Cell fate</subject><subject>Cell Proliferation - physiology</subject><subject>Central nervous system</subject><subject>Cerebellum</subject><subject>Corpus callosum</subject><subject>Cortex</subject><subject>Fate maps</subject><subject>Gene mapping</subject><subject>Homeostasis</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Mice</subject><subject>Microglia</subject><subject>Microglia - physiology</subject><subject>Myelin</subject><subject>Myelin Sheath - physiology</subject><subject>Myeloid cells</subject><subject>Neural stem cells</subject><subject>Neurons</subject><subject>Neurophysiology</subject><subject>Neurosciences</subject><subject>Oligodendrocyte Precursor Cells - physiology</subject><subject>Oligodendrocytes</subject><subject>Oligodendroglia - physiology</subject><subject>Original Paper</subject><subject>Pathology</subject><subject>Synapses</subject><subject>Transcription</subject><subject>Transcription (Genetics)</subject><issn>0001-6322</issn><issn>1432-0533</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNp1kl-L1TAQxYso7nX1A_giBV986ZpkmqR9EZbFf7Diiz6HNJl2s6TJNWkX7rc35a6XXVEKLen85oQzc6rqNSUXlBD5PhPSEtoQKhsq2_J6Uu1oC6whHOBptSOkVAUwdla9yPm2nJhs-fPqjHWi48BgV_lvzqQ4eadrE8OS3LAuWC-xDjHN2tfzAb0LccKA2eVaB7sVo3dTtBhsiuZQ-H3aCLfEVM_ahQWDDgZruyYXplrb1S83MdqX1bNR-4yv7r_n1c9PH39cfWmuv3_-enV53RhBYGnEKJAJM3CwVBPJihnoJTejFF3LQPeM26EDQrpRIwy9hFFSYD3rsRVcGDivPhx19-swozVYjGmv9snNOh1U1E49rgR3o6Z4p3jPqWS0CLy7F0jx14p5UbPLBr3XAeOaFe2pBAEtaQv69i_0Nq4pFHuFAsIYgzLqEzVpj8qFMZZ7zSaqLjmh0AvRyUJd_IMqj8XZlfXg6Mr_Rw302FB2mHPC8eSRErVFRB0jokpE1BYRtXl783A4p44_mSgAOwJ5v60P0wNH_1X9DQMdxv4</recordid><startdate>20170901</startdate><enddate>20170901</enddate><creator>Hagemeyer, Nora</creator><creator>Hanft, Klara-Maria</creator><creator>Akriditou, Maria-Anna</creator><creator>Unger, Nicole</creator><creator>Park, Eun S.</creator><creator>Stanley, E. 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| ispartof | Acta neuropathologica, 2017-09, Vol.134 (3), p.441-458 |
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| language | eng |
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| source | MEDLINE; SpringerLink Journals |
| subjects | Animals Brain Brain mapping Cell fate Cell Proliferation - physiology Central nervous system Cerebellum Corpus callosum Cortex Fate maps Gene mapping Homeostasis Medicine Medicine & Public Health Mice Microglia Microglia - physiology Myelin Myelin Sheath - physiology Myeloid cells Neural stem cells Neurons Neurophysiology Neurosciences Oligodendrocyte Precursor Cells - physiology Oligodendrocytes Oligodendroglia - physiology Original Paper Pathology Synapses Transcription Transcription (Genetics) |
| title | Microglia contribute to normal myelinogenesis and to oligodendrocyte progenitor maintenance during adulthood |
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