Treating a novel plasticity defect rescues episodic memory in Fragile X model mice

Episodic memory, a fundamental component of human cognition, is significantly impaired in autism. We believe we report the first evidence for this problem in the Fmr1 -knockout (KO) mouse model of Fragile X syndrome and describe potentially treatable underlying causes. The hippocampus is critical fo...

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Veröffentlicht in:	Molecular psychiatry 2018-08, Vol.23 (8), p.1798-1806
Hauptverfasser:	Wang, W, Cox, B M, Jia, Y, Le, A A, Cox, C D, Jung, K M, Hou, B, Piomelli, D, Gall, C M, Lynch, Gary
Format:	Artikel
Sprache:	eng
Schlagworte:	2-Arachidonoylglycerol Analysis Animals Arachidonic Acids - metabolism Autism Behavioral Sciences Biological Psychology Brain Cannabinoids Cognition Cognitive ability Discrimination, Psychological - drug effects Discrimination, Psychological - physiology Disease Models, Animal Endocannabinoids - metabolism Episodic memory Excitatory Postsynaptic Potentials - drug effects Excitatory Postsynaptic Potentials - physiology FMR1 protein Fragile X syndrome Fragile X Syndrome - drug therapy Fragile X Syndrome - metabolism Fragile X Syndrome - pathology Glutamic acid receptors (ionotropic) Glycerides - metabolism Health aspects Hippocampus Hippocampus - drug effects Hippocampus - metabolism Hippocampus - pathology Intellectual disabilities Laboratory rats Learning Long-Term Potentiation - drug effects Long-Term Potentiation - physiology Male Medicine Medicine & Public Health Memory Memory, Episodic Mice Mice, Knockout Mutants N-Methyl-D-aspartic acid receptors Nerve Tissue Proteins - metabolism Neurophysiology Neurosciences Neurotransmitter Agents - pharmacology Olfactory Perception - drug effects Olfactory Perception - physiology Patch-Clamp Techniques Pharmacotherapy Plasticity Psychiatry Receptor, Cannabinoid, CB1 - metabolism Receptors, N-Methyl-D-Aspartate - metabolism Synaptic plasticity Tissue Culture Techniques
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