Tumor-associated macrophages recruited by periostin in intrahepatic cholangiocarcinoma stem cells
Periostin (POSTN) secreted by intrahepatic cholangiocarcinoma stem cells (ICSCs) serves important roles in promoting tumor progression. The present study aimed to investigate POSTN-recruited tumor-associated macrophages (TAMs) in intrahepatic cholangiocarcinoma (ICC). A total of 50 cases were used t...
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| Veröffentlicht in: | Oncology letters 2018-06, Vol.15 (6), p.8681-8686 |
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| container_title | Oncology letters |
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| creator | Zeng, Jiehong Liu, Zhengkai Sun, Shuwen Xie, Jianhong Cao, Li Lv, Pin Nie, Shengdan Zhang, Bao Xie, Bowen Peng, Siyuan Jiang, Bo |
| description | Periostin (POSTN) secreted by intrahepatic cholangiocarcinoma stem cells (ICSCs) serves important roles in promoting tumor progression. The present study aimed to investigate POSTN-recruited tumor-associated macrophages (TAMs) in intrahepatic cholangiocarcinoma (ICC). A total of 50 cases were used to investigate the distribution of ICSCs and TAMs in ICC. HCCC-9810 cells were sorted by cluster of differentiation (CD)44, the expression of POSTN of CD44
(cancer stem cells) and CD44
cells (non-cancer stem cells), and medium were evaluated by western blot analysis. HCCC-9810 cells and THP-1 macrophages were used to detect the effects of POSTN on recruiting TAMs
. The present study revealed that CD44
cells in ICC tissues and the HCCC-9810 cell line were associated with high POSTN secretion levels. Furthermore, POSTN was associated with TAM density in primary ICC tissues. Additionally, POSTN increased the migration of TAMs derived from THP-1 cells. These findings suggested that POSTN secreted by ICSCs may serve important functions in TAM recruitment, and it may be a potential curative strategy to target the tumor microenvironment in ICC. |
| doi_str_mv | 10.3892/ol.2018.8372 |
| format | Article |
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(cancer stem cells) and CD44
cells (non-cancer stem cells), and medium were evaluated by western blot analysis. HCCC-9810 cells and THP-1 macrophages were used to detect the effects of POSTN on recruiting TAMs
. The present study revealed that CD44
cells in ICC tissues and the HCCC-9810 cell line were associated with high POSTN secretion levels. Furthermore, POSTN was associated with TAM density in primary ICC tissues. Additionally, POSTN increased the migration of TAMs derived from THP-1 cells. These findings suggested that POSTN secreted by ICSCs may serve important functions in TAM recruitment, and it may be a potential curative strategy to target the tumor microenvironment in ICC.</description><identifier>ISSN: 1792-1074</identifier><identifier>EISSN: 1792-1082</identifier><identifier>DOI: 10.3892/ol.2018.8372</identifier><identifier>PMID: 29805605</identifier><language>eng</language><publisher>Greece: Spandidos Publications</publisher><subject>Biliary tract cancer ; Biotechnology ; Cancer ; Care and treatment ; CD4 lymphocytes ; Cholangiocarcinoma ; Development and progression ; Growth factors ; Health aspects ; Immune response ; Kinases ; Medical prognosis ; Metastasis ; Observations ; Oncology ; Proteins ; Recruitment ; Stem cells ; Tumors</subject><ispartof>Oncology letters, 2018-06, Vol.15 (6), p.8681-8686</ispartof><rights>COPYRIGHT 2018 Spandidos Publications</rights><rights>Copyright Spandidos Publications UK Ltd. 2018</rights><rights>Copyright © 2018, Spandidos Publications 2018</rights><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c510t-bb12851a75ee2bcf0962bed0f7dca9a24e76450fee319be73aa2c75c473c26893</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5950521/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5950521/$$EHTML$$P50$$Gpubmedcentral$$H</linktohtml><link.rule.ids>230,314,727,780,784,885,27924,27925,53791,53793</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/29805605$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Zeng, Jiehong</creatorcontrib><creatorcontrib>Liu, Zhengkai</creatorcontrib><creatorcontrib>Sun, Shuwen</creatorcontrib><creatorcontrib>Xie, Jianhong</creatorcontrib><creatorcontrib>Cao, Li</creatorcontrib><creatorcontrib>Lv, Pin</creatorcontrib><creatorcontrib>Nie, Shengdan</creatorcontrib><creatorcontrib>Zhang, Bao</creatorcontrib><creatorcontrib>Xie, Bowen</creatorcontrib><creatorcontrib>Peng, Siyuan</creatorcontrib><creatorcontrib>Jiang, Bo</creatorcontrib><title>Tumor-associated macrophages recruited by periostin in intrahepatic cholangiocarcinoma stem cells</title><title>Oncology letters</title><addtitle>Oncol Lett</addtitle><description>Periostin (POSTN) secreted by intrahepatic cholangiocarcinoma stem cells (ICSCs) serves important roles in promoting tumor progression. The present study aimed to investigate POSTN-recruited tumor-associated macrophages (TAMs) in intrahepatic cholangiocarcinoma (ICC). A total of 50 cases were used to investigate the distribution of ICSCs and TAMs in ICC. HCCC-9810 cells were sorted by cluster of differentiation (CD)44, the expression of POSTN of CD44
(cancer stem cells) and CD44
cells (non-cancer stem cells), and medium were evaluated by western blot analysis. HCCC-9810 cells and THP-1 macrophages were used to detect the effects of POSTN on recruiting TAMs
. The present study revealed that CD44
cells in ICC tissues and the HCCC-9810 cell line were associated with high POSTN secretion levels. Furthermore, POSTN was associated with TAM density in primary ICC tissues. Additionally, POSTN increased the migration of TAMs derived from THP-1 cells. These findings suggested that POSTN secreted by ICSCs may serve important functions in TAM recruitment, and it may be a potential curative strategy to target the tumor microenvironment in ICC.</description><subject>Biliary tract cancer</subject><subject>Biotechnology</subject><subject>Cancer</subject><subject>Care and treatment</subject><subject>CD4 lymphocytes</subject><subject>Cholangiocarcinoma</subject><subject>Development and progression</subject><subject>Growth factors</subject><subject>Health aspects</subject><subject>Immune response</subject><subject>Kinases</subject><subject>Medical prognosis</subject><subject>Metastasis</subject><subject>Observations</subject><subject>Oncology</subject><subject>Proteins</subject><subject>Recruitment</subject><subject>Stem cells</subject><subject>Tumors</subject><issn>1792-1074</issn><issn>1792-1082</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><recordid>eNptkt9r3SAUx2VsrKXr255HYDD2sNypiTG-DErZLyjspXuWE3NyYzGaaVLofz_Tdne9Yyqox8_56jkeQl4zuqtaxT8Gt-OUtbu2kvwZOWVS8ZLRlj8_rGV9Qs5TuqG5iYa1bfOSnHDV5g0VpwSu1ynEElIKxsKCfTGBiWEeYY-piGjiajdrd1fMGG1Ii_XF_VgijDjDYk1hxuDA720wEI31YYIiLTgVBp1Lr8iLAVzC88f5jPz88vn68lt59ePr98uLq9IIRpey6xhvBQMpEHlnBqoa3mFPB9kbUMBrlE0t6IBYMdWhrAC4kcLUsjK8aVV1Rj496M5rN2FvcHuh03O0E8Q7HcDq4xNvR70Pt1ooQQVnWeD9o0AMv1ZMi55s2kIAj2FNmtO6oYwrKjP69h_0JqzR5_AypURd1YLTv9QeHGrrh5DvNZuovhCiFhXl91q7_1C59zhZEzwONtuPHN49cRgR3DKm4NbFBp-OwQ8PYP7QlCIOh2Qwqrfy0cHprXz0Vj4Zf_M0gQf4T7FUvwFDO8A6</recordid><startdate>20180601</startdate><enddate>20180601</enddate><creator>Zeng, Jiehong</creator><creator>Liu, Zhengkai</creator><creator>Sun, Shuwen</creator><creator>Xie, Jianhong</creator><creator>Cao, Li</creator><creator>Lv, Pin</creator><creator>Nie, Shengdan</creator><creator>Zhang, Bao</creator><creator>Xie, Bowen</creator><creator>Peng, Siyuan</creator><creator>Jiang, Bo</creator><general>Spandidos Publications</general><general>Spandidos Publications UK Ltd</general><general>D.A. Spandidos</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AN0</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20180601</creationdate><title>Tumor-associated macrophages recruited by periostin in intrahepatic cholangiocarcinoma stem cells</title><author>Zeng, Jiehong ; Liu, Zhengkai ; Sun, Shuwen ; Xie, Jianhong ; Cao, Li ; Lv, Pin ; Nie, Shengdan ; Zhang, Bao ; Xie, Bowen ; Peng, Siyuan ; Jiang, Bo</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c510t-bb12851a75ee2bcf0962bed0f7dca9a24e76450fee319be73aa2c75c473c26893</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2018</creationdate><topic>Biliary tract cancer</topic><topic>Biotechnology</topic><topic>Cancer</topic><topic>Care and treatment</topic><topic>CD4 lymphocytes</topic><topic>Cholangiocarcinoma</topic><topic>Development and progression</topic><topic>Growth factors</topic><topic>Health aspects</topic><topic>Immune response</topic><topic>Kinases</topic><topic>Medical prognosis</topic><topic>Metastasis</topic><topic>Observations</topic><topic>Oncology</topic><topic>Proteins</topic><topic>Recruitment</topic><topic>Stem cells</topic><topic>Tumors</topic><toplevel>online_resources</toplevel><creatorcontrib>Zeng, Jiehong</creatorcontrib><creatorcontrib>Liu, Zhengkai</creatorcontrib><creatorcontrib>Sun, Shuwen</creatorcontrib><creatorcontrib>Xie, Jianhong</creatorcontrib><creatorcontrib>Cao, Li</creatorcontrib><creatorcontrib>Lv, Pin</creatorcontrib><creatorcontrib>Nie, Shengdan</creatorcontrib><creatorcontrib>Zhang, Bao</creatorcontrib><creatorcontrib>Xie, Bowen</creatorcontrib><creatorcontrib>Peng, Siyuan</creatorcontrib><creatorcontrib>Jiang, Bo</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>British Nursing Database</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Oncology letters</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Zeng, Jiehong</au><au>Liu, Zhengkai</au><au>Sun, Shuwen</au><au>Xie, Jianhong</au><au>Cao, Li</au><au>Lv, Pin</au><au>Nie, Shengdan</au><au>Zhang, Bao</au><au>Xie, Bowen</au><au>Peng, Siyuan</au><au>Jiang, Bo</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Tumor-associated macrophages recruited by periostin in intrahepatic cholangiocarcinoma stem cells</atitle><jtitle>Oncology letters</jtitle><addtitle>Oncol Lett</addtitle><date>2018-06-01</date><risdate>2018</risdate><volume>15</volume><issue>6</issue><spage>8681</spage><epage>8686</epage><pages>8681-8686</pages><issn>1792-1074</issn><eissn>1792-1082</eissn><abstract>Periostin (POSTN) secreted by intrahepatic cholangiocarcinoma stem cells (ICSCs) serves important roles in promoting tumor progression. The present study aimed to investigate POSTN-recruited tumor-associated macrophages (TAMs) in intrahepatic cholangiocarcinoma (ICC). A total of 50 cases were used to investigate the distribution of ICSCs and TAMs in ICC. HCCC-9810 cells were sorted by cluster of differentiation (CD)44, the expression of POSTN of CD44
(cancer stem cells) and CD44
cells (non-cancer stem cells), and medium were evaluated by western blot analysis. HCCC-9810 cells and THP-1 macrophages were used to detect the effects of POSTN on recruiting TAMs
. The present study revealed that CD44
cells in ICC tissues and the HCCC-9810 cell line were associated with high POSTN secretion levels. Furthermore, POSTN was associated with TAM density in primary ICC tissues. Additionally, POSTN increased the migration of TAMs derived from THP-1 cells. These findings suggested that POSTN secreted by ICSCs may serve important functions in TAM recruitment, and it may be a potential curative strategy to target the tumor microenvironment in ICC.</abstract><cop>Greece</cop><pub>Spandidos Publications</pub><pmid>29805605</pmid><doi>10.3892/ol.2018.8372</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Oncology letters, 2018-06, Vol.15 (6), p.8681-8686 |
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| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_5950521 |
| source | Spandidos Publications Journals; EZB-FREE-00999 freely available EZB journals; PubMed Central |
| subjects | Biliary tract cancer Biotechnology Cancer Care and treatment CD4 lymphocytes Cholangiocarcinoma Development and progression Growth factors Health aspects Immune response Kinases Medical prognosis Metastasis Observations Oncology Proteins Recruitment Stem cells Tumors |
| title | Tumor-associated macrophages recruited by periostin in intrahepatic cholangiocarcinoma stem cells |
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