Exosome: Function and Role in Cancer Metastasis and Drug Resistance
As a kind of nanometric lipidic vesicles, exosomes have been presumed to play a leading role in the regulation of tumor microenvironment through exosomes-mediated transfer of proteins and genetic materials. Tumor-derived exosomes are recognized as a critical determinant of the tumor progression. Int...
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| Veröffentlicht in: | Technology in cancer research & treatment 2018-01, Vol.17, p.1533033818763450-1533033818763450 |
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| container_title | Technology in cancer research & treatment |
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| creator | Zhang, Chengcheng Ji, Qing Yang, Yue Li, Qi Wang, Zhongqi |
| description | As a kind of nanometric lipidic vesicles, exosomes have been presumed to play a leading role in the regulation of tumor microenvironment through exosomes-mediated transfer of proteins and genetic materials. Tumor-derived exosomes are recognized as a critical determinant of the tumor progression. Intriguingly, some current observations have identified that exosomes are essential for several intercellular exchanges of proteins, messenger RNAs, noncoding RNAs (including long noncoding RNAs and microRNAs) as well as to the process of cancer metastasis and drug resistance. Herein, we review the role of exosomes and their molecular cargos in cancer invasion and metastasis, summarize how they interact with antitumor agents, and highlight their translational implications. |
| doi_str_mv | 10.1177/1533033818763450 |
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| source | MEDLINE; DOAJ Directory of Open Access Journals; Sage Journals GOLD Open Access 2024; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central |
| subjects | Animals Cancer Drug resistance Drug Resistance, Neoplasm - physiology Exosomes - pathology Humans Metastasis Neoplasm Invasiveness - pathology Neoplasms - pathology Review |
| title | Exosome: Function and Role in Cancer Metastasis and Drug Resistance |
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