Cyclobutanone Mimics of Intermediates in Metallo‐β‐Lactamase Catalysis

The most important resistance mechanism to β‐lactam antibiotics involves hydrolysis by two β‐lactamase categories: the nucleophilic serine and the metallo‐β‐lactamases (SBLs and MBLs, respectively). Cyclobutanones are hydrolytically stable β‐lactam analogues with potential to inhibit both SBLs and M...

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Veröffentlicht in:	Chemistry : a European journal 2018-04, Vol.24 (22), p.5734-5737
Hauptverfasser:	Abboud, Martine I., Kosmopoulou, Magda, Krismanich, Anthony P., Johnson, Jarrod W., Hinchliffe, Philip, Brem, Jürgen, Claridge, Timothy D. W., Spencer, James, Schofield, Christopher J., Dmitrienko, Gary I.
Format:	Artikel
Sprache:	eng
Schlagworte:	Amides Antibiotics Antimicrobial agents antimicrobial resistance beta-Lactamase Inhibitors - chemistry beta-Lactamase Inhibitors - pharmacology beta-Lactamases - chemistry beta-Lactamases - classification beta-Lactamases - metabolism beta-Lactams - chemistry Bound water Catalysis Chemical bonds Chemistry Communication Communications Crystal structure Crystallography Cyclobutanes - chemistry cyclobutanones Hydrogen bonding Hydrophobicity Intermediates Meropenem Metallography Molecular Mimicry NMR Nuclear magnetic resonance Nuclear Magnetic Resonance, Biomolecular Serine Substrates Thienamycins - chemistry transition state analogues Zinc β-lactam analogues β-Lactam antibiotics β-lactamases
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