Siglec‐1 inhibits RSV‐induced interferon gamma production by adult T cells in contrast to newborn T cells
Interferon gamma (IFN‐γ) plays an important role in the antiviral immune response during respiratory syncytial virus (RSV) infections. Monocytes and T cells are recruited to the site of RSV infection, but it is unclear whether cell‐cell interactions between monocytes and T cells regulate IFN‐γ produ...
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| Veröffentlicht in: | European journal of immunology 2018-04, Vol.48 (4), p.621-631 |
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| container_title | European journal of immunology |
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| creator | Jans, Jop Unger, Wendy W.J. Vissers, Marloes Ahout, Inge M.L. Schreurs, Inge Wickenhagen, Arthur Groot, Ronald Jonge, Marien I. Ferwerda, Gerben |
| description | Interferon gamma (IFN‐γ) plays an important role in the antiviral immune response during respiratory syncytial virus (RSV) infections. Monocytes and T cells are recruited to the site of RSV infection, but it is unclear whether cell‐cell interactions between monocytes and T cells regulate IFN‐γ production. In this study, micro‐array data identified the upregulation of sialic acid‐binding immunoglobulin‐type lectin 1 (Siglec‐1) in human RSV‐infected infants. In vitro, RSV increased expression of Siglec‐1 on healthy newborn and adult monocytes. RSV‐induced Siglec‐1 on monocytes inhibited IFN‐γ production by adult CD4+ T cells. In contrast, IFN‐γ production by RSV in newborns was not affected by Siglec‐1. The ligand for Siglec‐1, CD43, is highly expressed on adult CD4+ T cells compared to newborns. Our data show that Siglec‐1 reduces IFN‐γ release by adult T cells possibly by binding to the highly expressed CD43. The Siglec‐1‐dependent inhibition of IFN‐γ in adults and the low expression of CD43 on newborn T cells provides a better understanding of the immune response against RSV in early life and adulthood.
RSV induces expression of Siglec‐1 on newborn and adult monocytes. Siglec‐1 inhibits RSV‐induced IFN‐γ release by adult T cells whereas the production of IFN‐γ by newborns is not affected by Siglec‐1. The expression of CD43, the natural ligand for Siglec‐1, is lower on newborn CD4+ T cells compared to adults. |
| doi_str_mv | 10.1002/eji.201747161 |
| format | Article |
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RSV induces expression of Siglec‐1 on newborn and adult monocytes. Siglec‐1 inhibits RSV‐induced IFN‐γ release by adult T cells whereas the production of IFN‐γ by newborns is not affected by Siglec‐1. The expression of CD43, the natural ligand for Siglec‐1, is lower on newborn CD4+ T cells compared to adults.</description><identifier>ISSN: 0014-2980</identifier><identifier>EISSN: 1521-4141</identifier><identifier>DOI: 10.1002/eji.201747161</identifier><identifier>PMID: 29266251</identifier><language>eng</language><publisher>Germany: Wiley Subscription Services, Inc</publisher><subject>Age Factors ; CD4 antigen ; CD4-Positive T-Lymphocytes - immunology ; CD43 ; CD43 antigen ; Cell interactions ; Clinical ; Humans ; Immune response ; Immunity to infection ; Infant, Newborn ; Infants ; Infections ; Interferon ; Interferon gamma ; Interferon-gamma - biosynthesis ; Interferon-gamma - immunology ; Leukosialin - metabolism ; Lymphocytes ; Lymphocytes T ; Monocytes ; Monocytes - immunology ; Neonates ; Newborns ; Respiratory syncytial virus ; Respiratory Syncytial Virus Infections - immunology ; Respiratory Syncytial Virus Infections - virology ; Respiratory Syncytial Virus, Human - immunology ; Sialic Acid Binding Ig-like Lectin 1 - immunology ; Siglec‐1 ; Up-Regulation - immunology</subject><ispartof>European journal of immunology, 2018-04, Vol.48 (4), p.621-631</ispartof><rights>2017 The Authors. published by WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim.</rights><rights>2017 The Authors. European Journal of Immunology published by WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.</rights><rights>2018 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3732-12ea023b85b60ded346c4ab5c38599f9e5949ce8514c13d4c5779125a5d712ea3</citedby><cites>FETCH-LOGICAL-c3732-12ea023b85b60ded346c4ab5c38599f9e5949ce8514c13d4c5779125a5d712ea3</cites><orcidid>0000-0003-0305-0671</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Feji.201747161$$EPDF$$P50$$Gwiley$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Feji.201747161$$EHTML$$P50$$Gwiley$$Hfree_for_read</linktohtml><link.rule.ids>230,314,780,784,885,1416,1432,27915,27916,45565,45566,46400,46824</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/29266251$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Jans, Jop</creatorcontrib><creatorcontrib>Unger, Wendy W.J.</creatorcontrib><creatorcontrib>Vissers, Marloes</creatorcontrib><creatorcontrib>Ahout, Inge M.L.</creatorcontrib><creatorcontrib>Schreurs, Inge</creatorcontrib><creatorcontrib>Wickenhagen, Arthur</creatorcontrib><creatorcontrib>Groot, Ronald</creatorcontrib><creatorcontrib>Jonge, Marien I.</creatorcontrib><creatorcontrib>Ferwerda, Gerben</creatorcontrib><title>Siglec‐1 inhibits RSV‐induced interferon gamma production by adult T cells in contrast to newborn T cells</title><title>European journal of immunology</title><addtitle>Eur J Immunol</addtitle><description>Interferon gamma (IFN‐γ) plays an important role in the antiviral immune response during respiratory syncytial virus (RSV) infections. Monocytes and T cells are recruited to the site of RSV infection, but it is unclear whether cell‐cell interactions between monocytes and T cells regulate IFN‐γ production. In this study, micro‐array data identified the upregulation of sialic acid‐binding immunoglobulin‐type lectin 1 (Siglec‐1) in human RSV‐infected infants. In vitro, RSV increased expression of Siglec‐1 on healthy newborn and adult monocytes. RSV‐induced Siglec‐1 on monocytes inhibited IFN‐γ production by adult CD4+ T cells. In contrast, IFN‐γ production by RSV in newborns was not affected by Siglec‐1. The ligand for Siglec‐1, CD43, is highly expressed on adult CD4+ T cells compared to newborns. Our data show that Siglec‐1 reduces IFN‐γ release by adult T cells possibly by binding to the highly expressed CD43. The Siglec‐1‐dependent inhibition of IFN‐γ in adults and the low expression of CD43 on newborn T cells provides a better understanding of the immune response against RSV in early life and adulthood.
RSV induces expression of Siglec‐1 on newborn and adult monocytes. Siglec‐1 inhibits RSV‐induced IFN‐γ release by adult T cells whereas the production of IFN‐γ by newborns is not affected by Siglec‐1. The expression of CD43, the natural ligand for Siglec‐1, is lower on newborn CD4+ T cells compared to adults.</description><subject>Age Factors</subject><subject>CD4 antigen</subject><subject>CD4-Positive T-Lymphocytes - immunology</subject><subject>CD43</subject><subject>CD43 antigen</subject><subject>Cell interactions</subject><subject>Clinical</subject><subject>Humans</subject><subject>Immune response</subject><subject>Immunity to infection</subject><subject>Infant, Newborn</subject><subject>Infants</subject><subject>Infections</subject><subject>Interferon</subject><subject>Interferon gamma</subject><subject>Interferon-gamma - biosynthesis</subject><subject>Interferon-gamma - immunology</subject><subject>Leukosialin - metabolism</subject><subject>Lymphocytes</subject><subject>Lymphocytes T</subject><subject>Monocytes</subject><subject>Monocytes - immunology</subject><subject>Neonates</subject><subject>Newborns</subject><subject>Respiratory syncytial virus</subject><subject>Respiratory Syncytial Virus Infections - immunology</subject><subject>Respiratory Syncytial Virus Infections - virology</subject><subject>Respiratory Syncytial Virus, Human - immunology</subject><subject>Sialic Acid Binding Ig-like Lectin 1 - immunology</subject><subject>Siglec‐1</subject><subject>Up-Regulation - immunology</subject><issn>0014-2980</issn><issn>1521-4141</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><sourceid>24P</sourceid><sourceid>WIN</sourceid><sourceid>EIF</sourceid><recordid>eNp9kcGKFDEURYMoTju6dCsBN25qzEsllcpGkGHUkQHBGd2GVOp1T5qqpE2qZuidn-An-C1-il9imh4bdeEiPHj35PIul5CnwE6AMf4S1_6EM1BCQQP3yAIkh0qAgPtkwRiIiuuWHZFHOa8ZY7qR-iE54po3DZewIPHSrwZ0P79-A-rDte_8lOnHy89l4UM_O-zLesK0xBQDXdlxtHSTYlEmXxbdltp-HiZ69eO7w2HIhaYuhinZPNEp0oC3XUzhoD8mD5Z2yPjkbh6TT2_Ork7fVRcf3p6fvr6oXK1qXgFHy3jdtbJrWI99LRonbCdd3UqtlxqlFtphK0E4qHvhpFIauLSyV7u_9TF5tffdzN2IvcPdSYPZJD_atDXRevO3Evy1WcUbU4xVecXgxZ1Bil9mzJMZfd5FsAHjnA1opSVruZAFff4Puo5zCiWe4YyLtoVGQ6GqPeVSzDnh8nAMMLOr0pQqzaHKwj_7M8GB_t1dAfgeuPUDbv_vZs7enwtQvP4FFeGtMw</recordid><startdate>201804</startdate><enddate>201804</enddate><creator>Jans, Jop</creator><creator>Unger, Wendy W.J.</creator><creator>Vissers, Marloes</creator><creator>Ahout, Inge M.L.</creator><creator>Schreurs, Inge</creator><creator>Wickenhagen, Arthur</creator><creator>Groot, Ronald</creator><creator>Jonge, Marien I.</creator><creator>Ferwerda, Gerben</creator><general>Wiley Subscription Services, Inc</general><general>John Wiley and Sons Inc</general><scope>24P</scope><scope>WIN</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QP</scope><scope>7T5</scope><scope>7TK</scope><scope>7TM</scope><scope>8FD</scope><scope>FR3</scope><scope>H94</scope><scope>K9.</scope><scope>M7N</scope><scope>P64</scope><scope>RC3</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0003-0305-0671</orcidid></search><sort><creationdate>201804</creationdate><title>Siglec‐1 inhibits RSV‐induced interferon gamma production by adult T cells in contrast to newborn T cells</title><author>Jans, Jop ; Unger, Wendy W.J. ; Vissers, Marloes ; Ahout, Inge M.L. ; Schreurs, Inge ; Wickenhagen, Arthur ; Groot, Ronald ; Jonge, Marien I. ; Ferwerda, Gerben</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3732-12ea023b85b60ded346c4ab5c38599f9e5949ce8514c13d4c5779125a5d712ea3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2018</creationdate><topic>Age Factors</topic><topic>CD4 antigen</topic><topic>CD4-Positive T-Lymphocytes - immunology</topic><topic>CD43</topic><topic>CD43 antigen</topic><topic>Cell interactions</topic><topic>Clinical</topic><topic>Humans</topic><topic>Immune response</topic><topic>Immunity to infection</topic><topic>Infant, Newborn</topic><topic>Infants</topic><topic>Infections</topic><topic>Interferon</topic><topic>Interferon gamma</topic><topic>Interferon-gamma - biosynthesis</topic><topic>Interferon-gamma - immunology</topic><topic>Leukosialin - metabolism</topic><topic>Lymphocytes</topic><topic>Lymphocytes T</topic><topic>Monocytes</topic><topic>Monocytes - immunology</topic><topic>Neonates</topic><topic>Newborns</topic><topic>Respiratory syncytial virus</topic><topic>Respiratory Syncytial Virus Infections - immunology</topic><topic>Respiratory Syncytial Virus Infections - virology</topic><topic>Respiratory Syncytial Virus, Human - immunology</topic><topic>Sialic Acid Binding Ig-like Lectin 1 - immunology</topic><topic>Siglec‐1</topic><topic>Up-Regulation - immunology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Jans, Jop</creatorcontrib><creatorcontrib>Unger, Wendy W.J.</creatorcontrib><creatorcontrib>Vissers, Marloes</creatorcontrib><creatorcontrib>Ahout, Inge M.L.</creatorcontrib><creatorcontrib>Schreurs, Inge</creatorcontrib><creatorcontrib>Wickenhagen, Arthur</creatorcontrib><creatorcontrib>Groot, Ronald</creatorcontrib><creatorcontrib>Jonge, Marien I.</creatorcontrib><creatorcontrib>Ferwerda, Gerben</creatorcontrib><collection>Wiley Online Library Open Access</collection><collection>Wiley Online Library Free Content</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Immunology Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>European journal of immunology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Jans, Jop</au><au>Unger, Wendy W.J.</au><au>Vissers, Marloes</au><au>Ahout, Inge M.L.</au><au>Schreurs, Inge</au><au>Wickenhagen, Arthur</au><au>Groot, Ronald</au><au>Jonge, Marien I.</au><au>Ferwerda, Gerben</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Siglec‐1 inhibits RSV‐induced interferon gamma production by adult T cells in contrast to newborn T cells</atitle><jtitle>European journal of immunology</jtitle><addtitle>Eur J Immunol</addtitle><date>2018-04</date><risdate>2018</risdate><volume>48</volume><issue>4</issue><spage>621</spage><epage>631</epage><pages>621-631</pages><issn>0014-2980</issn><eissn>1521-4141</eissn><abstract>Interferon gamma (IFN‐γ) plays an important role in the antiviral immune response during respiratory syncytial virus (RSV) infections. Monocytes and T cells are recruited to the site of RSV infection, but it is unclear whether cell‐cell interactions between monocytes and T cells regulate IFN‐γ production. In this study, micro‐array data identified the upregulation of sialic acid‐binding immunoglobulin‐type lectin 1 (Siglec‐1) in human RSV‐infected infants. In vitro, RSV increased expression of Siglec‐1 on healthy newborn and adult monocytes. RSV‐induced Siglec‐1 on monocytes inhibited IFN‐γ production by adult CD4+ T cells. In contrast, IFN‐γ production by RSV in newborns was not affected by Siglec‐1. The ligand for Siglec‐1, CD43, is highly expressed on adult CD4+ T cells compared to newborns. Our data show that Siglec‐1 reduces IFN‐γ release by adult T cells possibly by binding to the highly expressed CD43. The Siglec‐1‐dependent inhibition of IFN‐γ in adults and the low expression of CD43 on newborn T cells provides a better understanding of the immune response against RSV in early life and adulthood.
RSV induces expression of Siglec‐1 on newborn and adult monocytes. Siglec‐1 inhibits RSV‐induced IFN‐γ release by adult T cells whereas the production of IFN‐γ by newborns is not affected by Siglec‐1. The expression of CD43, the natural ligand for Siglec‐1, is lower on newborn CD4+ T cells compared to adults.</abstract><cop>Germany</cop><pub>Wiley Subscription Services, Inc</pub><pmid>29266251</pmid><doi>10.1002/eji.201747161</doi><tpages>11</tpages><orcidid>https://orcid.org/0000-0003-0305-0671</orcidid><oa>free_for_read</oa></addata></record> |
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| subjects | Age Factors CD4 antigen CD4-Positive T-Lymphocytes - immunology CD43 CD43 antigen Cell interactions Clinical Humans Immune response Immunity to infection Infant, Newborn Infants Infections Interferon Interferon gamma Interferon-gamma - biosynthesis Interferon-gamma - immunology Leukosialin - metabolism Lymphocytes Lymphocytes T Monocytes Monocytes - immunology Neonates Newborns Respiratory syncytial virus Respiratory Syncytial Virus Infections - immunology Respiratory Syncytial Virus Infections - virology Respiratory Syncytial Virus, Human - immunology Sialic Acid Binding Ig-like Lectin 1 - immunology Siglec‐1 Up-Regulation - immunology |
| title | Siglec‐1 inhibits RSV‐induced interferon gamma production by adult T cells in contrast to newborn T cells |
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