Immunological memories of the bone marrow
Summary Memory for antigens once encountered is a hallmark of the immune system of vertebrates, providing us with an immunity adapted to pathogens of our environment. Despite its fundamental relevance, the cells and genes representing immunological memory are still poorly understood. Here we discuss...
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| Veröffentlicht in: | Immunological reviews 2018-05, Vol.283 (1), p.86-98 |
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| container_title | Immunological reviews |
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| creator | Chang, Hyun‐Dong Tokoyoda, Koji Radbruch, Andreas |
| description | Summary
Memory for antigens once encountered is a hallmark of the immune system of vertebrates, providing us with an immunity adapted to pathogens of our environment. Despite its fundamental relevance, the cells and genes representing immunological memory are still poorly understood. Here we discuss the concept of a circulating, proliferating, and ubiquitous population of effector lymphocytes vs concepts of resting and dormant populations of dedicated memory lymphocytes, distinct from effector lymphocytes and residing in defined tissues, particularly in barrier tissues and in the bone marrow. The lifestyle of memory plasma cells of the bone marrow may serve as a paradigm, showing that persistence of memory lymphocytes is not defined by intrinsic “half‐lives”, but rather conditional on distinct survival signals provided by dedicated niches. These niches are organized by individual mesenchymal stromal cells. They define the capacity of immunological memory and regulate its homeostasis. |
| doi_str_mv | 10.1111/imr.12656 |
| format | Article |
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Memory for antigens once encountered is a hallmark of the immune system of vertebrates, providing us with an immunity adapted to pathogens of our environment. Despite its fundamental relevance, the cells and genes representing immunological memory are still poorly understood. Here we discuss the concept of a circulating, proliferating, and ubiquitous population of effector lymphocytes vs concepts of resting and dormant populations of dedicated memory lymphocytes, distinct from effector lymphocytes and residing in defined tissues, particularly in barrier tissues and in the bone marrow. The lifestyle of memory plasma cells of the bone marrow may serve as a paradigm, showing that persistence of memory lymphocytes is not defined by intrinsic “half‐lives”, but rather conditional on distinct survival signals provided by dedicated niches. These niches are organized by individual mesenchymal stromal cells. They define the capacity of immunological memory and regulate its homeostasis.</description><identifier>ISSN: 0105-2896</identifier><identifier>EISSN: 1600-065X</identifier><identifier>DOI: 10.1111/imr.12656</identifier><identifier>PMID: 29664564</identifier><language>eng</language><publisher>England: Wiley Subscription Services, Inc</publisher><subject>Animals ; Antigens ; Bone marrow ; Bone Marrow - immunology ; Bone Marrow - metabolism ; Bone Marrow Cells - immunology ; Bone Marrow Cells - metabolism ; Cell Survival - immunology ; Homeostasis ; Humans ; Immune system ; Immunity ; Immunologic Memory ; Immunological memory ; Immunology ; Invited Review ; Invited Reviews ; Lymphocyte Activation - immunology ; Lymphocytes ; memory T cells ; Mesenchyme ; Organ Specificity - immunology ; Plasma cells ; Plasma Cells - immunology ; Plasma Cells - metabolism ; Stromal cells ; T-Lymphocyte Subsets - immunology ; T-Lymphocyte Subsets - metabolism ; Tissues ; tissue‐resident memory ; Vertebrates</subject><ispartof>Immunological reviews, 2018-05, Vol.283 (1), p.86-98</ispartof><rights>2018 The Authors. Immunological Reviews Published by John Wiley & Sons Ltd.</rights><rights>2018 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c5096-578adddffbed43ac4e72dbcf3858563bd578987b70c2100f8f10e36e247e859c3</citedby><cites>FETCH-LOGICAL-c5096-578adddffbed43ac4e72dbcf3858563bd578987b70c2100f8f10e36e247e859c3</cites><orcidid>0000-0001-5753-0000</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fimr.12656$$EPDF$$P50$$Gwiley$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fimr.12656$$EHTML$$P50$$Gwiley$$Hfree_for_read</linktohtml><link.rule.ids>230,314,776,780,881,1411,27901,27902,45550,45551</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/29664564$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Chang, Hyun‐Dong</creatorcontrib><creatorcontrib>Tokoyoda, Koji</creatorcontrib><creatorcontrib>Radbruch, Andreas</creatorcontrib><title>Immunological memories of the bone marrow</title><title>Immunological reviews</title><addtitle>Immunol Rev</addtitle><description>Summary
Memory for antigens once encountered is a hallmark of the immune system of vertebrates, providing us with an immunity adapted to pathogens of our environment. Despite its fundamental relevance, the cells and genes representing immunological memory are still poorly understood. Here we discuss the concept of a circulating, proliferating, and ubiquitous population of effector lymphocytes vs concepts of resting and dormant populations of dedicated memory lymphocytes, distinct from effector lymphocytes and residing in defined tissues, particularly in barrier tissues and in the bone marrow. The lifestyle of memory plasma cells of the bone marrow may serve as a paradigm, showing that persistence of memory lymphocytes is not defined by intrinsic “half‐lives”, but rather conditional on distinct survival signals provided by dedicated niches. These niches are organized by individual mesenchymal stromal cells. They define the capacity of immunological memory and regulate its homeostasis.</description><subject>Animals</subject><subject>Antigens</subject><subject>Bone marrow</subject><subject>Bone Marrow - immunology</subject><subject>Bone Marrow - metabolism</subject><subject>Bone Marrow Cells - immunology</subject><subject>Bone Marrow Cells - metabolism</subject><subject>Cell Survival - immunology</subject><subject>Homeostasis</subject><subject>Humans</subject><subject>Immune system</subject><subject>Immunity</subject><subject>Immunologic Memory</subject><subject>Immunological memory</subject><subject>Immunology</subject><subject>Invited Review</subject><subject>Invited Reviews</subject><subject>Lymphocyte Activation - immunology</subject><subject>Lymphocytes</subject><subject>memory T cells</subject><subject>Mesenchyme</subject><subject>Organ Specificity - immunology</subject><subject>Plasma cells</subject><subject>Plasma Cells - immunology</subject><subject>Plasma Cells - metabolism</subject><subject>Stromal cells</subject><subject>T-Lymphocyte Subsets - immunology</subject><subject>T-Lymphocyte Subsets - metabolism</subject><subject>Tissues</subject><subject>tissue‐resident memory</subject><subject>Vertebrates</subject><issn>0105-2896</issn><issn>1600-065X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><sourceid>24P</sourceid><sourceid>EIF</sourceid><recordid>eNp1kV1LwzAUhoMobk4v_ANS8MZddEvSJE1vBBl-DCaCKHgX2vR062ibmayO_XszN4cK5uZc5OHhPedF6JzgAfFvWNZ2QKjg4gB1icA4xIK_HaIuJpiHVCaig06cm2NM4oiyY9ShiRCMC9ZF_XFdt42pzLTUaRXUUBtbggtMESxnEGSmgaBOrTWrU3RUpJWDs93sode725fRQzh5uh-Pbiah5jgRIY9lmud5UWSQsyjVDGKaZ7qIJJdcRFnugUTGWYw1JRgXsiAYIgGUxSB5oqMeut56F21WQ66hWdq0Ugtb-hxrZdJS_f5pypmamg_FExYTGnnB1U5gzXsLbqnq0mmoqrQB0zpFMRWM0ihJPHr5B52b1jZ-vQ3FJcMxEZ7qbyltjXMWin0YgtWmAOULUF8FePbiZ_o9-X1xDwy3wKqsYP2_SY0fn7fKT3R6jyQ</recordid><startdate>201805</startdate><enddate>201805</enddate><creator>Chang, Hyun‐Dong</creator><creator>Tokoyoda, Koji</creator><creator>Radbruch, Andreas</creator><general>Wiley Subscription Services, Inc</general><general>John Wiley and Sons Inc</general><scope>24P</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QL</scope><scope>7T5</scope><scope>7U9</scope><scope>C1K</scope><scope>H94</scope><scope>M7N</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0001-5753-0000</orcidid></search><sort><creationdate>201805</creationdate><title>Immunological memories of the bone marrow</title><author>Chang, Hyun‐Dong ; Tokoyoda, Koji ; Radbruch, Andreas</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c5096-578adddffbed43ac4e72dbcf3858563bd578987b70c2100f8f10e36e247e859c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2018</creationdate><topic>Animals</topic><topic>Antigens</topic><topic>Bone marrow</topic><topic>Bone Marrow - immunology</topic><topic>Bone Marrow - metabolism</topic><topic>Bone Marrow Cells - immunology</topic><topic>Bone Marrow Cells - metabolism</topic><topic>Cell Survival - immunology</topic><topic>Homeostasis</topic><topic>Humans</topic><topic>Immune system</topic><topic>Immunity</topic><topic>Immunologic Memory</topic><topic>Immunological memory</topic><topic>Immunology</topic><topic>Invited Review</topic><topic>Invited Reviews</topic><topic>Lymphocyte Activation - immunology</topic><topic>Lymphocytes</topic><topic>memory T cells</topic><topic>Mesenchyme</topic><topic>Organ Specificity - immunology</topic><topic>Plasma cells</topic><topic>Plasma Cells - immunology</topic><topic>Plasma Cells - metabolism</topic><topic>Stromal cells</topic><topic>T-Lymphocyte Subsets - immunology</topic><topic>T-Lymphocyte Subsets - metabolism</topic><topic>Tissues</topic><topic>tissue‐resident memory</topic><topic>Vertebrates</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Chang, Hyun‐Dong</creatorcontrib><creatorcontrib>Tokoyoda, Koji</creatorcontrib><creatorcontrib>Radbruch, Andreas</creatorcontrib><collection>Wiley Online Library Open Access</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Immunology Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Environmental Sciences and Pollution Management</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Immunological reviews</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Chang, Hyun‐Dong</au><au>Tokoyoda, Koji</au><au>Radbruch, Andreas</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Immunological memories of the bone marrow</atitle><jtitle>Immunological reviews</jtitle><addtitle>Immunol Rev</addtitle><date>2018-05</date><risdate>2018</risdate><volume>283</volume><issue>1</issue><spage>86</spage><epage>98</epage><pages>86-98</pages><issn>0105-2896</issn><eissn>1600-065X</eissn><abstract>Summary
Memory for antigens once encountered is a hallmark of the immune system of vertebrates, providing us with an immunity adapted to pathogens of our environment. Despite its fundamental relevance, the cells and genes representing immunological memory are still poorly understood. Here we discuss the concept of a circulating, proliferating, and ubiquitous population of effector lymphocytes vs concepts of resting and dormant populations of dedicated memory lymphocytes, distinct from effector lymphocytes and residing in defined tissues, particularly in barrier tissues and in the bone marrow. The lifestyle of memory plasma cells of the bone marrow may serve as a paradigm, showing that persistence of memory lymphocytes is not defined by intrinsic “half‐lives”, but rather conditional on distinct survival signals provided by dedicated niches. These niches are organized by individual mesenchymal stromal cells. They define the capacity of immunological memory and regulate its homeostasis.</abstract><cop>England</cop><pub>Wiley Subscription Services, Inc</pub><pmid>29664564</pmid><doi>10.1111/imr.12656</doi><tpages>13</tpages><orcidid>https://orcid.org/0000-0001-5753-0000</orcidid><oa>free_for_read</oa></addata></record> |
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| source | Wiley Online Library - AutoHoldings Journals; MEDLINE |
| subjects | Animals Antigens Bone marrow Bone Marrow - immunology Bone Marrow - metabolism Bone Marrow Cells - immunology Bone Marrow Cells - metabolism Cell Survival - immunology Homeostasis Humans Immune system Immunity Immunologic Memory Immunological memory Immunology Invited Review Invited Reviews Lymphocyte Activation - immunology Lymphocytes memory T cells Mesenchyme Organ Specificity - immunology Plasma cells Plasma Cells - immunology Plasma Cells - metabolism Stromal cells T-Lymphocyte Subsets - immunology T-Lymphocyte Subsets - metabolism Tissues tissue‐resident memory Vertebrates |
| title | Immunological memories of the bone marrow |
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