TGF-β1 Evokes Human Airway Smooth Muscle Cell Shortening and Hyperresponsiveness via Smad3

Transforming growth factor β1 (TGF-β1), a cytokine whose levels are elevated in the airways of patients with asthma, perpetuates airway inflammation and modulates airway structural cell remodeling. However, the role of TGF-β1 in excessive airway narrowing in asthma, or airway hyperresponsiveness (AH...

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Veröffentlicht in:	American journal of respiratory cell and molecular biology 2018-05, Vol.58 (5), p.575-584
Hauptverfasser:	Ojiaku, Christie A, Cao, Gaoyuan, Zhu, Wanqu, Yoo, Edwin J, Shumyatcher, Maya, Himes, Blanca E, An, Steven S, Panettieri, Jr, Reynold A
Format:	Artikel
Sprache:	eng
Schlagworte:	Asthma Asthma - metabolism Asthma - physiopathology Bronchial Hyperreactivity - metabolism Bronchial Hyperreactivity - physiopathology Bronchoconstriction Bronchoconstriction - drug effects Calcium Calcium Signaling - drug effects Carbachol Cells, Cultured Contraction Cytokines Cytometry Cytoskeleton Drug dosages Excitation Contraction Coupling - drug effects Excitation-contraction coupling Fibroblasts Gene expression Growth factors Humans Inflammation Kinases Methacholine Muscle, Smooth - drug effects Muscle, Smooth - metabolism Muscle, Smooth - physiopathology Myocytes, Smooth Muscle - drug effects Myocytes, Smooth Muscle - metabolism Myosin Myosin Light Chains - metabolism Myosin-Light-Chain Phosphatase - metabolism Original Research Phosphatase Phosphorylation Protein expression Proteins Respiratory tract Respiratory tract diseases Rho-associated kinase rho-Associated Kinases - metabolism rhoA GTP-Binding Protein - metabolism Rodents siRNA Smad3 protein Smad3 Protein - genetics Smad3 Protein - metabolism Smooth muscle Transforming Growth Factor beta1 - pharmacology Transforming growth factor-b1
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