Mannose Receptor Modulates Macrophage Polarization and Allergic Inflammation through miR-511-3p

Abstract Background Mannose receptor (MRC1/CD206) has been suggested to mediate allergic sensitization and asthma to multiple glyco-allergens, including cockroach allergens. Objective Determine the existence of a protective mechanism through which MRC1 limits allergic inflammation through its intron...

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Veröffentlicht in:	Journal of allergy and clinical immunology 2018-01, Vol.141 (1), p.350-364.e8
Hauptverfasser:	Zhou, Yufeng, MD, PhD, Do, Danh C., PhD, Ishmael, Faoud T., MD, PhD, Squadrito, Mario Leonardo, PhD, Tang, Ho Man, MS, Tang, Ho Lam, PhD, Hsu, Man-Hsun, PhD, Qiu, Lipeng, PhD, Li, Changjun, MD, PhD, Zhang, Yongqing, PhD, Becker, Kevin G., PhD, Wan, Mei, PhD, Huang, Shau-Ku, PhD, Gao, Peisong, MD, PhD
Format:	Artikel
Sprache:	eng
Schlagworte:	Allergens - immunology Allergies Allergy and Immunology Animals Antigens Asthma Asthma - etiology Asthma - metabolism Asthma - pathology Bone marrow Cockroaches - immunology Cytokines Flow cytometry Gene expression Gene Expression Profiling Gene Expression Regulation Genetic Vectors - genetics Green fluorescent protein Helper cells Hypersensitivity Hypersensitivity - etiology Hypersensitivity - metabolism Hypersensitivity - pathology Immunoglobulin E Inflammation Inner city Laboratories Lectins, C-Type - metabolism Lungs Lymphocytes T macrophage Macrophage Activation - genetics Macrophage Activation - immunology Macrophages Macrophages - immunology Macrophages - metabolism Macrophages, Alveolar - immunology Macrophages, Alveolar - metabolism Mannose Mannose Receptor Mannose-Binding Lectins - metabolism Membrane Glycoproteins - genetics Membrane Glycoproteins - metabolism Mice Mice, Knockout MicroRNAs MicroRNAs - genetics Microscopy miR-511-3p Models, Biological Plasma levels Pneumonia - etiology Pneumonia - metabolism Pneumonia - pathology Polarization Receptors, Cell Surface - genetics Receptors, Cell Surface - metabolism Receptors, Immunologic RNA Interference Rodents Viruses
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