Working Memory Impairments in Chromosome 22q11.2 Deletion Syndrome: The Roles of Anxiety and Stress Physiology
Stress and anxiety have a negative impact on working memory systems by competing for executive resources and attention. Broad memory deficits, anxiety, and elevated stress have been reported in individuals with chromosome 22q11.2 deletion syndrome (22q11.2DS). We investigated anxiety and physiologic...
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| Veröffentlicht in: | Journal of autism and developmental disorders 2017-04, Vol.47 (4), p.992-1005 |
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| creator | Sanders, Ashley F. P. Hobbs, Diana A. Stephenson, David D. Laird, Robert D. Beaton, Elliott A. |
| description | Stress and anxiety have a negative impact on working memory systems by competing for executive resources and attention. Broad memory deficits, anxiety, and elevated stress have been reported in individuals with chromosome 22q11.2 deletion syndrome (22q11.2DS). We investigated anxiety and physiological stress reactivity in relation to visuospatial working memory impairments in 20 children with 22q11.2DS and 32 typically developing (TD) children ages 7 to 16. Children with 22q11.2DS demonstrated poorer working memory, reduced post-stress respiratory sinus arrhythmia recovery, and overall increased levels of cortisol in comparison to TD children. Anxiety, but not physiological stress responsivity, mediated the relationship between 22q11.2DS diagnosis and visuospatial working memory impairment. Findings indicate that anxiety exacerbates impaired working memory in children with 22q11.2DS. |
| doi_str_mv | 10.1007/s10803-016-3011-2 |
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P. ; Hobbs, Diana A. ; Stephenson, David D. ; Laird, Robert D. ; Beaton, Elliott A.</creator><creatorcontrib>Sanders, Ashley F. P. ; Hobbs, Diana A. ; Stephenson, David D. ; Laird, Robert D. ; Beaton, Elliott A.</creatorcontrib><description>Stress and anxiety have a negative impact on working memory systems by competing for executive resources and attention. Broad memory deficits, anxiety, and elevated stress have been reported in individuals with chromosome 22q11.2 deletion syndrome (22q11.2DS). We investigated anxiety and physiological stress reactivity in relation to visuospatial working memory impairments in 20 children with 22q11.2DS and 32 typically developing (TD) children ages 7 to 16. Children with 22q11.2DS demonstrated poorer working memory, reduced post-stress respiratory sinus arrhythmia recovery, and overall increased levels of cortisol in comparison to TD children. Anxiety, but not physiological stress responsivity, mediated the relationship between 22q11.2DS diagnosis and visuospatial working memory impairment. Findings indicate that anxiety exacerbates impaired working memory in children with 22q11.2DS.</description><identifier>ISSN: 0162-3257</identifier><identifier>EISSN: 1573-3432</identifier><identifier>DOI: 10.1007/s10803-016-3011-2</identifier><identifier>PMID: 28083777</identifier><identifier>CODEN: JADDDQ</identifier><language>eng</language><publisher>New York: Springer US</publisher><subject>Abnormalities ; Adolescent ; Adolescents ; Anatomy ; Anxiety ; Anxiety - psychology ; Arrhythmia ; Autism ; Behavioral Science and Psychology ; Cardiac arrhythmia ; Child ; Child and School Psychology ; Children ; Chromosome 22 ; Chromosome abnormalities ; Chromosome deletion ; Chromosomes ; Clonal deletion ; Comparative Analysis ; Complications and side effects ; Consciousness ; Control Groups ; Control theory ; Cortisol ; Daily Living Skills ; DiGeorge Syndrome - physiopathology ; DiGeorge Syndrome - psychology ; Efficiency ; Executive Function ; Female ; Genetic aspects ; Genetic counseling ; Genetic Disorders ; Health aspects ; Hormones ; Humans ; Hydrocortisone ; Hydrocortisone - analysis ; Intelligence Quotient ; Male ; Medical diagnosis ; Memorization ; Memory ; Memory Disorders - physiopathology ; Memory Disorders - psychology ; Memory, Short-Term - physiology ; Neurosciences ; Original Paper ; Pediatrics ; Physiological reactivity ; Physiology ; Psychology ; Psychopathology ; Public Health ; Reactivity ; Recall (Psychology) ; Recovery ; Respiration ; Respiratory Sinus Arrhythmia - physiology ; Short Term Memory ; Spatial Ability ; Spatial memory ; Stimuli ; Stress ; Stress Variables ; Stress, Physiological - physiology ; Teenagers ; Visual memory ; Visual Perception ; Visual task performance</subject><ispartof>Journal of autism and developmental disorders, 2017-04, Vol.47 (4), p.992-1005</ispartof><rights>Springer Science+Business Media New York 2017</rights><rights>COPYRIGHT 2017 Springer</rights><rights>Journal of Autism and Developmental Disorders is a copyright of Springer, 2017.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c730t-66a36c00093d26b869ee2ac42c5d59c8ce22249275c6f3b1116a8b7f1780de7a3</citedby><cites>FETCH-LOGICAL-c730t-66a36c00093d26b869ee2ac42c5d59c8ce22249275c6f3b1116a8b7f1780de7a3</cites><orcidid>0000-0001-7631-4637</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s10803-016-3011-2$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s10803-016-3011-2$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>230,315,782,786,887,12853,27931,27932,31006,41495,42564,51326</link.rule.ids><backlink>$$Uhttp://eric.ed.gov/ERICWebPortal/detail?accno=EJ1134169$$DView record in ERIC$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/28083777$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Sanders, Ashley F. P.</creatorcontrib><creatorcontrib>Hobbs, Diana A.</creatorcontrib><creatorcontrib>Stephenson, David D.</creatorcontrib><creatorcontrib>Laird, Robert D.</creatorcontrib><creatorcontrib>Beaton, Elliott A.</creatorcontrib><title>Working Memory Impairments in Chromosome 22q11.2 Deletion Syndrome: The Roles of Anxiety and Stress Physiology</title><title>Journal of autism and developmental disorders</title><addtitle>J Autism Dev Disord</addtitle><addtitle>J Autism Dev Disord</addtitle><description>Stress and anxiety have a negative impact on working memory systems by competing for executive resources and attention. Broad memory deficits, anxiety, and elevated stress have been reported in individuals with chromosome 22q11.2 deletion syndrome (22q11.2DS). We investigated anxiety and physiological stress reactivity in relation to visuospatial working memory impairments in 20 children with 22q11.2DS and 32 typically developing (TD) children ages 7 to 16. Children with 22q11.2DS demonstrated poorer working memory, reduced post-stress respiratory sinus arrhythmia recovery, and overall increased levels of cortisol in comparison to TD children. Anxiety, but not physiological stress responsivity, mediated the relationship between 22q11.2DS diagnosis and visuospatial working memory impairment. Findings indicate that anxiety exacerbates impaired working memory in children with 22q11.2DS.</description><subject>Abnormalities</subject><subject>Adolescent</subject><subject>Adolescents</subject><subject>Anatomy</subject><subject>Anxiety</subject><subject>Anxiety - psychology</subject><subject>Arrhythmia</subject><subject>Autism</subject><subject>Behavioral Science and Psychology</subject><subject>Cardiac arrhythmia</subject><subject>Child</subject><subject>Child and School Psychology</subject><subject>Children</subject><subject>Chromosome 22</subject><subject>Chromosome abnormalities</subject><subject>Chromosome deletion</subject><subject>Chromosomes</subject><subject>Clonal deletion</subject><subject>Comparative Analysis</subject><subject>Complications and side effects</subject><subject>Consciousness</subject><subject>Control Groups</subject><subject>Control theory</subject><subject>Cortisol</subject><subject>Daily Living Skills</subject><subject>DiGeorge Syndrome - physiopathology</subject><subject>DiGeorge Syndrome - psychology</subject><subject>Efficiency</subject><subject>Executive Function</subject><subject>Female</subject><subject>Genetic aspects</subject><subject>Genetic counseling</subject><subject>Genetic Disorders</subject><subject>Health aspects</subject><subject>Hormones</subject><subject>Humans</subject><subject>Hydrocortisone</subject><subject>Hydrocortisone - analysis</subject><subject>Intelligence Quotient</subject><subject>Male</subject><subject>Medical diagnosis</subject><subject>Memorization</subject><subject>Memory</subject><subject>Memory Disorders - physiopathology</subject><subject>Memory Disorders - psychology</subject><subject>Memory, Short-Term - physiology</subject><subject>Neurosciences</subject><subject>Original Paper</subject><subject>Pediatrics</subject><subject>Physiological reactivity</subject><subject>Physiology</subject><subject>Psychology</subject><subject>Psychopathology</subject><subject>Public Health</subject><subject>Reactivity</subject><subject>Recall (Psychology)</subject><subject>Recovery</subject><subject>Respiration</subject><subject>Respiratory Sinus Arrhythmia - physiology</subject><subject>Short Term Memory</subject><subject>Spatial Ability</subject><subject>Spatial memory</subject><subject>Stimuli</subject><subject>Stress</subject><subject>Stress Variables</subject><subject>Stress, Physiological - physiology</subject><subject>Teenagers</subject><subject>Visual memory</subject><subject>Visual Perception</subject><subject>Visual task performance</subject><issn>0162-3257</issn><issn>1573-3432</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>7QJ</sourceid><sourceid>8G5</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNqNkl9v0zAUxSMEYmXwAXgAWeIFHlL8J7EdHpCqMqBoCLQO8Wi5zk3qkdidnaL12-Oqo6yoSMgPlnx-9_j6-mTZU4LHBGPxOhIsMcsx4TnDhOT0XjYipWA5Kxi9n42SQHNGS3GSPYrxCmNcSUofZidUYsmEEKPMfffhh3Ut-gy9Dxs061fahh7cEJF1aLoMvvfR94AovSZkTNE76GCw3qH5xtVJhTfocgnowncQkW_QxN1YGDZIuxrNhwAxoq_LTbS-8-3mcfag0V2EJ7f7afbt_dnl9GN-_uXDbDo5z41geMg514ybbb-spnwheQVAtSmoKeuyMtIApbSoqCgNb9iCEMK1XIiGCIlrEJqdZm93vqv1oofapPcE3alVsL0OG-W1VYeKs0vV-p-qrIqCMZEMXt4aBH-9hjio3kYDXacd-HVUREoieFmQ_0E5KXghuEzoi7_QK78OLk0iUaJiRBaM_6Fa3YGyrvGpRbM1VZOyxFVJOd565UeoFhyk93gHjU3HB_z4CJ9WDb01RwteHRQkZoCbodXrGNVsfnHIkh1rgo8xQLMfNcFqm1W1y6pKkVTbrCqaap7f_aN9xe9wJuDZDoBgzV4--0QIKwivkk53ekyaayHcmeY_b_0FE2750g</recordid><startdate>20170401</startdate><enddate>20170401</enddate><creator>Sanders, Ashley F. 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P. ; Hobbs, Diana A. ; Stephenson, David D. ; Laird, Robert D. ; Beaton, Elliott A.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c730t-66a36c00093d26b869ee2ac42c5d59c8ce22249275c6f3b1116a8b7f1780de7a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><topic>Abnormalities</topic><topic>Adolescent</topic><topic>Adolescents</topic><topic>Anatomy</topic><topic>Anxiety</topic><topic>Anxiety - psychology</topic><topic>Arrhythmia</topic><topic>Autism</topic><topic>Behavioral Science and Psychology</topic><topic>Cardiac arrhythmia</topic><topic>Child</topic><topic>Child and School Psychology</topic><topic>Children</topic><topic>Chromosome 22</topic><topic>Chromosome abnormalities</topic><topic>Chromosome deletion</topic><topic>Chromosomes</topic><topic>Clonal deletion</topic><topic>Comparative Analysis</topic><topic>Complications and side effects</topic><topic>Consciousness</topic><topic>Control Groups</topic><topic>Control theory</topic><topic>Cortisol</topic><topic>Daily Living Skills</topic><topic>DiGeorge Syndrome - physiopathology</topic><topic>DiGeorge Syndrome - psychology</topic><topic>Efficiency</topic><topic>Executive Function</topic><topic>Female</topic><topic>Genetic aspects</topic><topic>Genetic counseling</topic><topic>Genetic Disorders</topic><topic>Health aspects</topic><topic>Hormones</topic><topic>Humans</topic><topic>Hydrocortisone</topic><topic>Hydrocortisone - analysis</topic><topic>Intelligence Quotient</topic><topic>Male</topic><topic>Medical diagnosis</topic><topic>Memorization</topic><topic>Memory</topic><topic>Memory Disorders - physiopathology</topic><topic>Memory Disorders - psychology</topic><topic>Memory, Short-Term - physiology</topic><topic>Neurosciences</topic><topic>Original Paper</topic><topic>Pediatrics</topic><topic>Physiological reactivity</topic><topic>Physiology</topic><topic>Psychology</topic><topic>Psychopathology</topic><topic>Public Health</topic><topic>Reactivity</topic><topic>Recall (Psychology)</topic><topic>Recovery</topic><topic>Respiration</topic><topic>Respiratory Sinus Arrhythmia - physiology</topic><topic>Short Term Memory</topic><topic>Spatial Ability</topic><topic>Spatial memory</topic><topic>Stimuli</topic><topic>Stress</topic><topic>Stress Variables</topic><topic>Stress, Physiological - physiology</topic><topic>Teenagers</topic><topic>Visual memory</topic><topic>Visual Perception</topic><topic>Visual task performance</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Sanders, Ashley F. 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P.</au><au>Hobbs, Diana A.</au><au>Stephenson, David D.</au><au>Laird, Robert D.</au><au>Beaton, Elliott A.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><ericid>EJ1134169</ericid><atitle>Working Memory Impairments in Chromosome 22q11.2 Deletion Syndrome: The Roles of Anxiety and Stress Physiology</atitle><jtitle>Journal of autism and developmental disorders</jtitle><stitle>J Autism Dev Disord</stitle><addtitle>J Autism Dev Disord</addtitle><date>2017-04-01</date><risdate>2017</risdate><volume>47</volume><issue>4</issue><spage>992</spage><epage>1005</epage><pages>992-1005</pages><issn>0162-3257</issn><eissn>1573-3432</eissn><coden>JADDDQ</coden><abstract>Stress and anxiety have a negative impact on working memory systems by competing for executive resources and attention. Broad memory deficits, anxiety, and elevated stress have been reported in individuals with chromosome 22q11.2 deletion syndrome (22q11.2DS). We investigated anxiety and physiological stress reactivity in relation to visuospatial working memory impairments in 20 children with 22q11.2DS and 32 typically developing (TD) children ages 7 to 16. Children with 22q11.2DS demonstrated poorer working memory, reduced post-stress respiratory sinus arrhythmia recovery, and overall increased levels of cortisol in comparison to TD children. Anxiety, but not physiological stress responsivity, mediated the relationship between 22q11.2DS diagnosis and visuospatial working memory impairment. Findings indicate that anxiety exacerbates impaired working memory in children with 22q11.2DS.</abstract><cop>New York</cop><pub>Springer US</pub><pmid>28083777</pmid><doi>10.1007/s10803-016-3011-2</doi><tpages>14</tpages><orcidid>https://orcid.org/0000-0001-7631-4637</orcidid><oa>free_for_read</oa></addata></record> |
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| subjects | Abnormalities Adolescent Adolescents Anatomy Anxiety Anxiety - psychology Arrhythmia Autism Behavioral Science and Psychology Cardiac arrhythmia Child Child and School Psychology Children Chromosome 22 Chromosome abnormalities Chromosome deletion Chromosomes Clonal deletion Comparative Analysis Complications and side effects Consciousness Control Groups Control theory Cortisol Daily Living Skills DiGeorge Syndrome - physiopathology DiGeorge Syndrome - psychology Efficiency Executive Function Female Genetic aspects Genetic counseling Genetic Disorders Health aspects Hormones Humans Hydrocortisone Hydrocortisone - analysis Intelligence Quotient Male Medical diagnosis Memorization Memory Memory Disorders - physiopathology Memory Disorders - psychology Memory, Short-Term - physiology Neurosciences Original Paper Pediatrics Physiological reactivity Physiology Psychology Psychopathology Public Health Reactivity Recall (Psychology) Recovery Respiration Respiratory Sinus Arrhythmia - physiology Short Term Memory Spatial Ability Spatial memory Stimuli Stress Stress Variables Stress, Physiological - physiology Teenagers Visual memory Visual Perception Visual task performance |
| title | Working Memory Impairments in Chromosome 22q11.2 Deletion Syndrome: The Roles of Anxiety and Stress Physiology |
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