Multiple Bioactivities of Traditional Medicinal Herbs for Treatment of Neurodegenerative Diseases
The pathological effects of neurodegenerative diseases result from altered activity in multiple pathways. [...]new pharmacological therapeutic strategies, using natural compounds or medicinal herbal extracts comprising multiple compounds, are specifically designed to act on multiple neural and bioch...
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| Veröffentlicht in: | Evidence-based complementary and alternative medicine 2018-01, Vol.2018 (1), p.3075458-3075458 |
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| creator | Park, Gunhyuk Kusuma, Irawan W. Kim, Yong-ung |
| description | The pathological effects of neurodegenerative diseases result from altered activity in multiple pathways. [...]new pharmacological therapeutic strategies, using natural compounds or medicinal herbal extracts comprising multiple compounds, are specifically designed to act on multiple neural and biochemical targets. Lim et al. reported the effect and possible mechanism of Jodeungsan (JDS), a traditional herbal formula, on lipopolysaccharide or H2O2-induced neurotoxicity in hippocampal neurons and microglia and suggested that JDS extracts might suppress tumor necrosis factor-α and interleukin-6 production, supporting the antineuroinflammatory activity. Lee et al. demonstrated the antioxidative effects of α-pinene on scopolamine-induced learning and memory impairments in C57BL/6 mice and suggested that the effects may be due to elevated expression of choline acetyltransferase and antioxidant enzymes, mediated via activation of the NF-E2-related factor 2 (Nrf2) pathway. [...]α-pinene may be a candidate for the treatment of AD. |
| doi_str_mv | 10.1155/2018/3075458 |
| format | Article |
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[...]new pharmacological therapeutic strategies, using natural compounds or medicinal herbal extracts comprising multiple compounds, are specifically designed to act on multiple neural and biochemical targets. Lim et al. reported the effect and possible mechanism of Jodeungsan (JDS), a traditional herbal formula, on lipopolysaccharide or H2O2-induced neurotoxicity in hippocampal neurons and microglia and suggested that JDS extracts might suppress tumor necrosis factor-α and interleukin-6 production, supporting the antineuroinflammatory activity. Lee et al. demonstrated the antioxidative effects of α-pinene on scopolamine-induced learning and memory impairments in C57BL/6 mice and suggested that the effects may be due to elevated expression of choline acetyltransferase and antioxidant enzymes, mediated via activation of the NF-E2-related factor 2 (Nrf2) pathway. [...]α-pinene may be a candidate for the treatment of AD.</description><identifier>ISSN: 1741-427X</identifier><identifier>EISSN: 1741-4288</identifier><identifier>DOI: 10.1155/2018/3075458</identifier><identifier>PMID: 29849701</identifier><language>eng</language><publisher>United States: Hindawi</publisher><subject>Adenosine ; Age ; Alzheimer's disease ; Antioxidants ; Dementia ; Development and progression ; Disease ; Enzymes ; Herbal medicine ; Kinases ; Learning ; Lipopolysaccharides ; Medical treatment ; Medicinal herbs ; Medicinal plants ; Medicine, Botanic ; Medicine, Herbal ; Memory ; Nervous system ; Nervous system diseases ; Neurodegenerative diseases ; Neurotoxicity ; Proteins</subject><ispartof>Evidence-based complementary and alternative medicine, 2018-01, Vol.2018 (1), p.3075458-3075458</ispartof><rights>Copyright © 2018 Gunhyuk Park et al.</rights><rights>COPYRIGHT 2018 John Wiley & Sons, Inc.</rights><rights>Copyright © 2018 Gunhyuk Park et al.; This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.</rights><rights>Copyright © 2018 Gunhyuk Park et al. 2018</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c476t-2b3195ccfa8a80e7efbed40219e9901c2836fb244f0a45de2adf76ae0fa34d2c3</citedby><orcidid>0000-0002-6115-7533 ; 0000-0001-8911-831X</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5941717/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5941717/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,885,27924,27925,53791,53793</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/29849701$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Park, Gunhyuk</creatorcontrib><creatorcontrib>Kusuma, Irawan W.</creatorcontrib><creatorcontrib>Kim, Yong-ung</creatorcontrib><title>Multiple Bioactivities of Traditional Medicinal Herbs for Treatment of Neurodegenerative Diseases</title><title>Evidence-based complementary and alternative medicine</title><addtitle>Evid Based Complement Alternat Med</addtitle><description>The pathological effects of neurodegenerative diseases result from altered activity in multiple pathways. [...]new pharmacological therapeutic strategies, using natural compounds or medicinal herbal extracts comprising multiple compounds, are specifically designed to act on multiple neural and biochemical targets. Lim et al. reported the effect and possible mechanism of Jodeungsan (JDS), a traditional herbal formula, on lipopolysaccharide or H2O2-induced neurotoxicity in hippocampal neurons and microglia and suggested that JDS extracts might suppress tumor necrosis factor-α and interleukin-6 production, supporting the antineuroinflammatory activity. Lee et al. demonstrated the antioxidative effects of α-pinene on scopolamine-induced learning and memory impairments in C57BL/6 mice and suggested that the effects may be due to elevated expression of choline acetyltransferase and antioxidant enzymes, mediated via activation of the NF-E2-related factor 2 (Nrf2) pathway. [...]α-pinene may be a candidate for the treatment of AD.</description><subject>Adenosine</subject><subject>Age</subject><subject>Alzheimer's disease</subject><subject>Antioxidants</subject><subject>Dementia</subject><subject>Development and progression</subject><subject>Disease</subject><subject>Enzymes</subject><subject>Herbal medicine</subject><subject>Kinases</subject><subject>Learning</subject><subject>Lipopolysaccharides</subject><subject>Medical treatment</subject><subject>Medicinal herbs</subject><subject>Medicinal plants</subject><subject>Medicine, Botanic</subject><subject>Medicine, Herbal</subject><subject>Memory</subject><subject>Nervous system</subject><subject>Nervous system diseases</subject><subject>Neurodegenerative diseases</subject><subject>Neurotoxicity</subject><subject>Proteins</subject><issn>1741-427X</issn><issn>1741-4288</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><sourceid>RHX</sourceid><sourceid>8G5</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNp9kU1v1DAQhi1ERT_gxhlF4oJUltqOE9sXpFKgRWrhUiRu1sQeb11l462dFPHvcbTbpXDg5LHm0eMZv4S8ZPQdY01zwilTJzWVjWjUE3LApGALwZV6uqvlj31ymPMtpVxLKZ-Rfa6V0JKyAwJXUz-GdY_VhxDBjuE-jAFzFX11ncCVSxygr67QBRvm6gJTlysfU-kjjCscxhn-ilOKDpc4YIJiwepjyAgZ83Oy56HP-GJ7HpHvnz9dn10sLr-dfzk7vVxYIdtxwbua6cZaDwoURYm-QycoZxq1psxyVbe-40J4CqJxyMF52QJSD7Vw3NZH5P3Gu566FTpbBkvQm3UKK0i_TIRg_u4M4cYs471ptGCSySJ4sxWkeDdhHs0qZIt9DwPGKRtOhdRCMdoW9PU_6G2cUvmemaobzoXWzR9qCT2aMPhY3rWz1Jy2VNSsloIW6u2GsinmnNDvRmbUzAmbOWGzTbjgrx6vuYMfIi3A8Qa4CYODn-H_ut9qI67b</recordid><startdate>20180101</startdate><enddate>20180101</enddate><creator>Park, Gunhyuk</creator><creator>Kusuma, Irawan W.</creator><creator>Kim, Yong-ung</creator><general>Hindawi</general><general>John Wiley & Sons, Inc</general><general>Hindawi Limited</general><scope>RHU</scope><scope>RHW</scope><scope>RHX</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7RV</scope><scope>7T5</scope><scope>7TO</scope><scope>7X7</scope><scope>7XB</scope><scope>88G</scope><scope>8AO</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>H94</scope><scope>K9.</scope><scope>KB0</scope><scope>M0S</scope><scope>M2M</scope><scope>M2O</scope><scope>MBDVC</scope><scope>NAPCQ</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>PSYQQ</scope><scope>Q9U</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0002-6115-7533</orcidid><orcidid>https://orcid.org/0000-0001-8911-831X</orcidid></search><sort><creationdate>20180101</creationdate><title>Multiple Bioactivities of Traditional Medicinal Herbs for Treatment of Neurodegenerative Diseases</title><author>Park, Gunhyuk ; Kusuma, Irawan W. ; Kim, Yong-ung</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c476t-2b3195ccfa8a80e7efbed40219e9901c2836fb244f0a45de2adf76ae0fa34d2c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2018</creationdate><topic>Adenosine</topic><topic>Age</topic><topic>Alzheimer's disease</topic><topic>Antioxidants</topic><topic>Dementia</topic><topic>Development and progression</topic><topic>Disease</topic><topic>Enzymes</topic><topic>Herbal medicine</topic><topic>Kinases</topic><topic>Learning</topic><topic>Lipopolysaccharides</topic><topic>Medical treatment</topic><topic>Medicinal herbs</topic><topic>Medicinal plants</topic><topic>Medicine, Botanic</topic><topic>Medicine, Herbal</topic><topic>Memory</topic><topic>Nervous system</topic><topic>Nervous system diseases</topic><topic>Neurodegenerative diseases</topic><topic>Neurotoxicity</topic><topic>Proteins</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Park, Gunhyuk</creatorcontrib><creatorcontrib>Kusuma, Irawan W.</creatorcontrib><creatorcontrib>Kim, Yong-ung</creatorcontrib><collection>Hindawi Publishing Complete</collection><collection>Hindawi Publishing Subscription Journals</collection><collection>Hindawi Publishing Open Access Journals</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Nursing & Allied Health Database</collection><collection>Immunology Abstracts</collection><collection>Oncogenes and Growth Factors Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Psychology Database (Alumni)</collection><collection>ProQuest Pharma Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Research Library (Alumni Edition)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Research Library Prep</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Psychology Database (ProQuest)</collection><collection>Research Library</collection><collection>Research Library (Corporate)</collection><collection>Nursing & Allied Health Premium</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest One Psychology</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Evidence-based complementary and alternative medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Park, Gunhyuk</au><au>Kusuma, Irawan W.</au><au>Kim, Yong-ung</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Multiple Bioactivities of Traditional Medicinal Herbs for Treatment of Neurodegenerative Diseases</atitle><jtitle>Evidence-based complementary and alternative medicine</jtitle><addtitle>Evid Based Complement Alternat Med</addtitle><date>2018-01-01</date><risdate>2018</risdate><volume>2018</volume><issue>1</issue><spage>3075458</spage><epage>3075458</epage><pages>3075458-3075458</pages><issn>1741-427X</issn><eissn>1741-4288</eissn><abstract>The pathological effects of neurodegenerative diseases result from altered activity in multiple pathways. 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[...]α-pinene may be a candidate for the treatment of AD.</abstract><cop>United States</cop><pub>Hindawi</pub><pmid>29849701</pmid><doi>10.1155/2018/3075458</doi><tpages>1</tpages><orcidid>https://orcid.org/0000-0002-6115-7533</orcidid><orcidid>https://orcid.org/0000-0001-8911-831X</orcidid><oa>free_for_read</oa></addata></record> |
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| source | PubMed Central Open Access; Wiley-Blackwell Open Access Titles; EZB-FREE-00999 freely available EZB journals; PubMed Central; Alma/SFX Local Collection |
| subjects | Adenosine Age Alzheimer's disease Antioxidants Dementia Development and progression Disease Enzymes Herbal medicine Kinases Learning Lipopolysaccharides Medical treatment Medicinal herbs Medicinal plants Medicine, Botanic Medicine, Herbal Memory Nervous system Nervous system diseases Neurodegenerative diseases Neurotoxicity Proteins |
| title | Multiple Bioactivities of Traditional Medicinal Herbs for Treatment of Neurodegenerative Diseases |
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