Association between Snoring and High-Risk Carotid Plaque Features
Objectives Previous studies have demonstrated an association between snoring and carotid disease independent of sleep apnea. The aim of this study was to quantify the association between self-reported snoring and high-risk carotid plaque features on magnetic resonance imaging (MRI) that predict stro...
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| Veröffentlicht in: | Otolaryngology-head and neck surgery 2017-08, Vol.157 (2), p.336-344 |
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| creator | Kirkham, Erin M. Hatsukami, Thomas S. Heckbert, Susan R. Sun, Jie Canton, Gador Yuan, Chun Weaver, Edward M. |
| description | Objectives
Previous studies have demonstrated an association between snoring and carotid disease independent of sleep apnea. The aim of this study was to quantify the association between self-reported snoring and high-risk carotid plaque features on magnetic resonance imaging (MRI) that predict stroke.
Study Design
Cross-sectional.
Setting
Tertiary care university hospital and affiliated county hospital.
Methods
We surveyed 133 subjects with asymptomatic carotid artery disease that had been previously evaluated with high-resolution MRI. The survey captured data on self-reported snoring (exposure) and covariates (age, sex, body mass index, and sleep apnea via the STOP-Bang questionnaire). A subset of patients underwent home sleep apnea testing. High-risk carotid plaque features were identified on the high-resolution MRI and included thin/ruptured fibrous cap and intraplaque hemorrhage (outcomes). We quantified the association between snoring and high-risk carotid plaque features with the chi-square test (unadjusted analysis) and multivariate logistic regression adjusting for the covariates.
Results
Of 133 subjects surveyed, 61 (46%) responded; 32 (52%) reported snoring. Significantly higher proportions of snorers than nonsnorers had a thin/ruptured fibrous cap (56% vs 25%, P = .01) and intraplaque hemorrhage (63% vs 29%, P < .01). In multivariate analysis, snoring was associated with thin/ruptured fibrous cap (odds ratio, 4.4; 95% CI, 1.1-16.6; P = .04) and intraplaque hemorrhage (odds ratio, 8.2; 95% CI, 2.1-31.6; P < .01) after adjusting for age, sex, body mass index, and sleep apnea.
Conclusion
This pilot study suggests a significant independent association between snoring and high-risk carotid plaque features on MRI. Further study is warranted to confirm these results in a larger cohort of subjects. |
| doi_str_mv | 10.1177/0194599817715634 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_5940929</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sage_id>10.1177_0194599817715634</sage_id><sourcerecordid>1917960536</sourcerecordid><originalsourceid>FETCH-LOGICAL-c4831-c5bae143d2078ba50efa5bb1ae93f10ed313d262bef2508519cc968f7229cff83</originalsourceid><addsrcrecordid>eNqFUEtP4zAQthAIyuPOCeXIJaydxK8LUqkoXQkB4nG2HGdSDKkNdgLi3-OqLFqQEKcZzfeYmQ-hfYKPCOH8DyayolKK1BPKymoNjQiWPGdpso5GSzhf4ltoO8YHjDFjnG-irUIwSTnlIzQex-iN1b31LquhfwVw2Y3zwbp5pl2Tzez8Pr-28TGb6OB722RXnX4eIJuC7ocAcRdttLqLsPdRd9Dd9PR2MsvPL8_-TsbnualESXJDaw2kKpsCc1FriqHVtK6JBlm2BENTkoSxooa2oFhQIo2RTLS8KKRpW1HuoOOV79NQL6Ax4PqgO_UU7EKHN-W1VV8RZ-_V3L8oKissC5kMDj8Mgk8PxF4tbDTQddqBH6IiknDJMC1ZouIV1QQfY4D2cw3Bapm8-p58khz8f96n4F_UiSBWhFfbwduvhupydnEyxaKQJEnzlTTqOagHPwSXkv75lnd_8ZwP</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1917960536</pqid></control><display><type>article</type><title>Association between Snoring and High-Risk Carotid Plaque Features</title><source>MEDLINE</source><source>Wiley Online Library Journals Frontfile Complete</source><source>SAGE Complete A-Z List</source><creator>Kirkham, Erin M. ; Hatsukami, Thomas S. ; Heckbert, Susan R. ; Sun, Jie ; Canton, Gador ; Yuan, Chun ; Weaver, Edward M.</creator><creatorcontrib>Kirkham, Erin M. ; Hatsukami, Thomas S. ; Heckbert, Susan R. ; Sun, Jie ; Canton, Gador ; Yuan, Chun ; Weaver, Edward M.</creatorcontrib><description>Objectives
Previous studies have demonstrated an association between snoring and carotid disease independent of sleep apnea. The aim of this study was to quantify the association between self-reported snoring and high-risk carotid plaque features on magnetic resonance imaging (MRI) that predict stroke.
Study Design
Cross-sectional.
Setting
Tertiary care university hospital and affiliated county hospital.
Methods
We surveyed 133 subjects with asymptomatic carotid artery disease that had been previously evaluated with high-resolution MRI. The survey captured data on self-reported snoring (exposure) and covariates (age, sex, body mass index, and sleep apnea via the STOP-Bang questionnaire). A subset of patients underwent home sleep apnea testing. High-risk carotid plaque features were identified on the high-resolution MRI and included thin/ruptured fibrous cap and intraplaque hemorrhage (outcomes). We quantified the association between snoring and high-risk carotid plaque features with the chi-square test (unadjusted analysis) and multivariate logistic regression adjusting for the covariates.
Results
Of 133 subjects surveyed, 61 (46%) responded; 32 (52%) reported snoring. Significantly higher proportions of snorers than nonsnorers had a thin/ruptured fibrous cap (56% vs 25%, P = .01) and intraplaque hemorrhage (63% vs 29%, P < .01). In multivariate analysis, snoring was associated with thin/ruptured fibrous cap (odds ratio, 4.4; 95% CI, 1.1-16.6; P = .04) and intraplaque hemorrhage (odds ratio, 8.2; 95% CI, 2.1-31.6; P < .01) after adjusting for age, sex, body mass index, and sleep apnea.
Conclusion
This pilot study suggests a significant independent association between snoring and high-risk carotid plaque features on MRI. Further study is warranted to confirm these results in a larger cohort of subjects.</description><identifier>ISSN: 0194-5998</identifier><identifier>EISSN: 1097-6817</identifier><identifier>DOI: 10.1177/0194599817715634</identifier><identifier>PMID: 28695757</identifier><language>eng</language><publisher>Los Angeles, CA: SAGE Publications</publisher><subject>Aged ; atherosclerosis ; carotid ; Carotid Artery Diseases - diagnostic imaging ; Carotid Artery Diseases - etiology ; Cross-Sectional Studies ; Female ; high‐resolution MRI ; Humans ; Logistic Models ; Magnetic Resonance Imaging ; Male ; Middle Aged ; Pilot Projects ; Plaque, Atherosclerotic - diagnostic imaging ; Plaque, Atherosclerotic - etiology ; sleep apnea ; snoring ; Snoring - complications ; stroke</subject><ispartof>Otolaryngology-head and neck surgery, 2017-08, Vol.157 (2), p.336-344</ispartof><rights>American Academy of Otolaryngology—Head and Neck Surgery Foundation 2017</rights><rights>2017 American Association of Otolaryngology‐Head and Neck Surgery Foundation (AAO‐HNSF)</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4831-c5bae143d2078ba50efa5bb1ae93f10ed313d262bef2508519cc968f7229cff83</citedby><cites>FETCH-LOGICAL-c4831-c5bae143d2078ba50efa5bb1ae93f10ed313d262bef2508519cc968f7229cff83</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://journals.sagepub.com/doi/pdf/10.1177/0194599817715634$$EPDF$$P50$$Gsage$$H</linktopdf><linktohtml>$$Uhttps://journals.sagepub.com/doi/10.1177/0194599817715634$$EHTML$$P50$$Gsage$$H</linktohtml><link.rule.ids>230,314,778,782,883,1414,21802,27907,27908,43604,43605,45557,45558</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/28695757$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kirkham, Erin M.</creatorcontrib><creatorcontrib>Hatsukami, Thomas S.</creatorcontrib><creatorcontrib>Heckbert, Susan R.</creatorcontrib><creatorcontrib>Sun, Jie</creatorcontrib><creatorcontrib>Canton, Gador</creatorcontrib><creatorcontrib>Yuan, Chun</creatorcontrib><creatorcontrib>Weaver, Edward M.</creatorcontrib><title>Association between Snoring and High-Risk Carotid Plaque Features</title><title>Otolaryngology-head and neck surgery</title><addtitle>Otolaryngol Head Neck Surg</addtitle><description>Objectives
Previous studies have demonstrated an association between snoring and carotid disease independent of sleep apnea. The aim of this study was to quantify the association between self-reported snoring and high-risk carotid plaque features on magnetic resonance imaging (MRI) that predict stroke.
Study Design
Cross-sectional.
Setting
Tertiary care university hospital and affiliated county hospital.
Methods
We surveyed 133 subjects with asymptomatic carotid artery disease that had been previously evaluated with high-resolution MRI. The survey captured data on self-reported snoring (exposure) and covariates (age, sex, body mass index, and sleep apnea via the STOP-Bang questionnaire). A subset of patients underwent home sleep apnea testing. High-risk carotid plaque features were identified on the high-resolution MRI and included thin/ruptured fibrous cap and intraplaque hemorrhage (outcomes). We quantified the association between snoring and high-risk carotid plaque features with the chi-square test (unadjusted analysis) and multivariate logistic regression adjusting for the covariates.
Results
Of 133 subjects surveyed, 61 (46%) responded; 32 (52%) reported snoring. Significantly higher proportions of snorers than nonsnorers had a thin/ruptured fibrous cap (56% vs 25%, P = .01) and intraplaque hemorrhage (63% vs 29%, P < .01). In multivariate analysis, snoring was associated with thin/ruptured fibrous cap (odds ratio, 4.4; 95% CI, 1.1-16.6; P = .04) and intraplaque hemorrhage (odds ratio, 8.2; 95% CI, 2.1-31.6; P < .01) after adjusting for age, sex, body mass index, and sleep apnea.
Conclusion
This pilot study suggests a significant independent association between snoring and high-risk carotid plaque features on MRI. Further study is warranted to confirm these results in a larger cohort of subjects.</description><subject>Aged</subject><subject>atherosclerosis</subject><subject>carotid</subject><subject>Carotid Artery Diseases - diagnostic imaging</subject><subject>Carotid Artery Diseases - etiology</subject><subject>Cross-Sectional Studies</subject><subject>Female</subject><subject>high‐resolution MRI</subject><subject>Humans</subject><subject>Logistic Models</subject><subject>Magnetic Resonance Imaging</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Pilot Projects</subject><subject>Plaque, Atherosclerotic - diagnostic imaging</subject><subject>Plaque, Atherosclerotic - etiology</subject><subject>sleep apnea</subject><subject>snoring</subject><subject>Snoring - complications</subject><subject>stroke</subject><issn>0194-5998</issn><issn>1097-6817</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFUEtP4zAQthAIyuPOCeXIJaydxK8LUqkoXQkB4nG2HGdSDKkNdgLi3-OqLFqQEKcZzfeYmQ-hfYKPCOH8DyayolKK1BPKymoNjQiWPGdpso5GSzhf4ltoO8YHjDFjnG-irUIwSTnlIzQex-iN1b31LquhfwVw2Y3zwbp5pl2Tzez8Pr-28TGb6OB722RXnX4eIJuC7ocAcRdttLqLsPdRd9Dd9PR2MsvPL8_-TsbnualESXJDaw2kKpsCc1FriqHVtK6JBlm2BENTkoSxooa2oFhQIo2RTLS8KKRpW1HuoOOV79NQL6Ax4PqgO_UU7EKHN-W1VV8RZ-_V3L8oKissC5kMDj8Mgk8PxF4tbDTQddqBH6IiknDJMC1ZouIV1QQfY4D2cw3Bapm8-p58khz8f96n4F_UiSBWhFfbwduvhupydnEyxaKQJEnzlTTqOagHPwSXkv75lnd_8ZwP</recordid><startdate>201708</startdate><enddate>201708</enddate><creator>Kirkham, Erin M.</creator><creator>Hatsukami, Thomas S.</creator><creator>Heckbert, Susan R.</creator><creator>Sun, Jie</creator><creator>Canton, Gador</creator><creator>Yuan, Chun</creator><creator>Weaver, Edward M.</creator><general>SAGE Publications</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>201708</creationdate><title>Association between Snoring and High-Risk Carotid Plaque Features</title><author>Kirkham, Erin M. ; Hatsukami, Thomas S. ; Heckbert, Susan R. ; Sun, Jie ; Canton, Gador ; Yuan, Chun ; Weaver, Edward M.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4831-c5bae143d2078ba50efa5bb1ae93f10ed313d262bef2508519cc968f7229cff83</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><topic>Aged</topic><topic>atherosclerosis</topic><topic>carotid</topic><topic>Carotid Artery Diseases - diagnostic imaging</topic><topic>Carotid Artery Diseases - etiology</topic><topic>Cross-Sectional Studies</topic><topic>Female</topic><topic>high‐resolution MRI</topic><topic>Humans</topic><topic>Logistic Models</topic><topic>Magnetic Resonance Imaging</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Pilot Projects</topic><topic>Plaque, Atherosclerotic - diagnostic imaging</topic><topic>Plaque, Atherosclerotic - etiology</topic><topic>sleep apnea</topic><topic>snoring</topic><topic>Snoring - complications</topic><topic>stroke</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kirkham, Erin M.</creatorcontrib><creatorcontrib>Hatsukami, Thomas S.</creatorcontrib><creatorcontrib>Heckbert, Susan R.</creatorcontrib><creatorcontrib>Sun, Jie</creatorcontrib><creatorcontrib>Canton, Gador</creatorcontrib><creatorcontrib>Yuan, Chun</creatorcontrib><creatorcontrib>Weaver, Edward M.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Otolaryngology-head and neck surgery</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kirkham, Erin M.</au><au>Hatsukami, Thomas S.</au><au>Heckbert, Susan R.</au><au>Sun, Jie</au><au>Canton, Gador</au><au>Yuan, Chun</au><au>Weaver, Edward M.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Association between Snoring and High-Risk Carotid Plaque Features</atitle><jtitle>Otolaryngology-head and neck surgery</jtitle><addtitle>Otolaryngol Head Neck Surg</addtitle><date>2017-08</date><risdate>2017</risdate><volume>157</volume><issue>2</issue><spage>336</spage><epage>344</epage><pages>336-344</pages><issn>0194-5998</issn><eissn>1097-6817</eissn><abstract>Objectives
Previous studies have demonstrated an association between snoring and carotid disease independent of sleep apnea. The aim of this study was to quantify the association between self-reported snoring and high-risk carotid plaque features on magnetic resonance imaging (MRI) that predict stroke.
Study Design
Cross-sectional.
Setting
Tertiary care university hospital and affiliated county hospital.
Methods
We surveyed 133 subjects with asymptomatic carotid artery disease that had been previously evaluated with high-resolution MRI. The survey captured data on self-reported snoring (exposure) and covariates (age, sex, body mass index, and sleep apnea via the STOP-Bang questionnaire). A subset of patients underwent home sleep apnea testing. High-risk carotid plaque features were identified on the high-resolution MRI and included thin/ruptured fibrous cap and intraplaque hemorrhage (outcomes). We quantified the association between snoring and high-risk carotid plaque features with the chi-square test (unadjusted analysis) and multivariate logistic regression adjusting for the covariates.
Results
Of 133 subjects surveyed, 61 (46%) responded; 32 (52%) reported snoring. Significantly higher proportions of snorers than nonsnorers had a thin/ruptured fibrous cap (56% vs 25%, P = .01) and intraplaque hemorrhage (63% vs 29%, P < .01). In multivariate analysis, snoring was associated with thin/ruptured fibrous cap (odds ratio, 4.4; 95% CI, 1.1-16.6; P = .04) and intraplaque hemorrhage (odds ratio, 8.2; 95% CI, 2.1-31.6; P < .01) after adjusting for age, sex, body mass index, and sleep apnea.
Conclusion
This pilot study suggests a significant independent association between snoring and high-risk carotid plaque features on MRI. Further study is warranted to confirm these results in a larger cohort of subjects.</abstract><cop>Los Angeles, CA</cop><pub>SAGE Publications</pub><pmid>28695757</pmid><doi>10.1177/0194599817715634</doi><tpages>9</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0194-5998 |
| ispartof | Otolaryngology-head and neck surgery, 2017-08, Vol.157 (2), p.336-344 |
| issn | 0194-5998 1097-6817 |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_5940929 |
| source | MEDLINE; Wiley Online Library Journals Frontfile Complete; SAGE Complete A-Z List |
| subjects | Aged atherosclerosis carotid Carotid Artery Diseases - diagnostic imaging Carotid Artery Diseases - etiology Cross-Sectional Studies Female high‐resolution MRI Humans Logistic Models Magnetic Resonance Imaging Male Middle Aged Pilot Projects Plaque, Atherosclerotic - diagnostic imaging Plaque, Atherosclerotic - etiology sleep apnea snoring Snoring - complications stroke |
| title | Association between Snoring and High-Risk Carotid Plaque Features |
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