HDAC-mediated deacetylation of KLF5 associates with its proteasomal degradation

Krüppel-like factor 5 (KLF5) is a basic transcription factor that regulates diverse cellular processes during tumor development. Acetylation of KLF5 at lysine 369 (K369) reverses its function from promoting to suppressing cell proliferation and tumor growth. In this study, we examined the regulation...

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Veröffentlicht in:	Biochemical and biophysical research communications 2018-06, Vol.500 (3), p.777-782
Hauptverfasser:	Tao, Ran, Zhang, Baotong, Li, Yixiang, King, Jamie L., Tian, Ruoyu, Xia, Siyuan, Schiavon, Cara Rae, Dong, Jin-Tang
Format:	Artikel
Sprache:	eng
Schlagworte:	60 APPLIED LIFE SCIENCES ACETYLATION ARGININE Cell Line, Tumor cell lines CELL PROLIFERATION Cell Proliferation - genetics Down-Regulation - genetics enzyme activity gene expression regulation Gene Silencing histone deacetylase Histone Deacetylase 1 - metabolism Histone Deacetylase 2 - metabolism Histone deacetylases (HDACs) HISTONES Humans KLF5 Kruppel-Like Transcription Factors - genetics Kruppel-Like Transcription Factors - metabolism LYSINE Lysine - metabolism MESSENGER-RNA mutation neoplasm cells NEOPLASMS PROSTATE prostatic neoplasms Proteasome Endopeptidase Complex - metabolism Protein Binding protein content Protein Stability Proteolysis RNA, Messenger - genetics RNA, Messenger - metabolism TRANSCRIPTION FACTORS
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