Combinations of antioxidants and/or of epigenetic enzyme inhibitors allow for enhanced collection of mouse bone marrow hematopoietic stem cells in ambient air

Hematopoietic cell transplantation (HCT) is a treatment for malignant and non-malignant disorders. However, sometimes the numbers of donor hematopoietic stem cells (HSC) are limiting, which can compromise the success of HCT. We recently published that collection and processing of mouse bone marrow (...

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Veröffentlicht in:	Blood cells, molecules, & diseases molecules, & diseases, 2018-07, Vol.71, p.23-28
Hauptverfasser:	Cai, Qingchun, Capitano, Maegan, Huang, Xinxin, Guo, Bin, Cooper, Scott, Broxmeyer, Hal E.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antioxidants Antioxidants - pharmacology Bone Marrow Cells - drug effects Bone Marrow Cells - metabolism Colony-Forming Units Assay Enzyme Inhibitors - pharmacology Epigenesis, Genetic - drug effects Epigenetic enzyme inhibitors Female Graft Survival - drug effects Hematopoietic stem cell Hematopoietic Stem Cell Mobilization - methods Hematopoietic Stem Cell Transplantation Hematopoietic Stem Cells - cytology Hematopoietic Stem Cells - drug effects Hematopoietic Stem Cells - metabolism Hypoxia Hypoxia - genetics Hypoxia - metabolism Mice
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