Macrophage/microglial Ezh2 facilitates autoimmune inflammation through inhibition of Socs3

Histone 3 Lys27 (H3K27) trimethyltransferase Ezh2 is implicated in the pathogenesis of autoimmune inflammation. Nevertheless, the role of Ezh2 in macrophage/microglial activation remains to be defined. In this study, we identified that macrophage/microglial H3K27me3 or Ezh2, rather than functioning...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	The Journal of experimental medicine 2018-05, Vol.215 (5), p.1365-1382
Hauptverfasser:	Zhang, Xingli, Wang, Yan, Yuan, Jia, Li, Ni, Pei, Siyu, Xu, Jing, Luo, Xuan, Mao, Chaoming, Liu, Junli, Yu, Tao, Gan, Shucheng, Zheng, Qianqian, Liang, Yinming, Guo, Weixiang, Qiu, Ju, Constantin, Gabriela, Jin, Jin, Qin, Jun, Xiao, Yichuan
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Cell activation Colitis Colitis - chemically induced Colitis - metabolism Colitis - pathology Dextran Dextran Sulfate Encephalomyelitis, Autoimmune, Experimental - metabolism Encephalomyelitis, Autoimmune, Experimental - pathology Enhancer of Zeste Homolog 2 Protein - deficiency Enhancer of Zeste Homolog 2 Protein - metabolism Epigenesis, Genetic - drug effects Experimental allergic encephalomyelitis Gene expression Histones - metabolism Immune system Indoles - pharmacology Inflammation Inflammation - pathology Kinases Lysine - metabolism Macrophages Macrophages - drug effects Macrophages - metabolism Methylation Mice Microglia Microglia - drug effects Microglia - metabolism Models, Biological MyD88 protein Myeloid Differentiation Factor 88 - metabolism NF-κB protein Pathogenesis Proteins Proteolysis - drug effects Pyridones - pharmacology Rodents Signal Transduction - drug effects SOCS-3 protein Sodium Sulfates Suppressor of Cytokine Signaling 3 Protein - antagonists & inhibitors Suppressor of Cytokine Signaling 3 Protein - metabolism TNF Receptor-Associated Factor 6 - metabolism Toll-like receptors Ubiquitination
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!