Dopamine D3 Receptor Modulates l-DOPA-Induced Dyskinesia by Targeting D1 Receptor-Mediated Striatal Signaling

The dopamine D3 receptor (D3R) belongs to the dopamine D2-like receptor family and is principally located in the ventral striatum. However, previous studies reported D3R overexpression in the dorsal striatum following l-DOPA treatment in parkinsonian animals. This fact has drawn attention in the imp...

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Veröffentlicht in:	Cerebral cortex (New York, N.Y. 1991) N.Y. 1991), 2017-01, Vol.27 (1), p.435-446
Hauptverfasser:	Solís, Oscar, Garcia-Montes, Jose Ruben, González-Granillo, Aldo, Xu, Ming, Moratalla, Rosario
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Corpus Striatum - drug effects Corpus Striatum - metabolism Dopamine Agents - toxicity Dyskinesia, Drug-Induced - metabolism Levodopa - toxicity Mice Mice, Knockout Original Parkinsonian Disorders - metabolism Receptors, Dopamine D1 - metabolism Receptors, Dopamine D3 - metabolism
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