Regorafenib inhibits tumor progression through suppression of ERK/NF-κB activation in hepatocellular carcinoma bearing mice

Regorafenib has been demonstrated in our previous study to trigger apoptosis through suppression of extracellular signal-regulated kinase (ERK)/nuclear factor-κB (NF-κB) activation in hepatocellular carcinoma (HCC) SK-Hep1 cells However, the effect of regorafenib on NF-κB-modulated tumor progression...

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Veröffentlicht in:	Bioscience reports 2018-06, Vol.38 (3)
Hauptverfasser:	Weng, Mao-Chi, Wang, Mei-Hui, Tsai, Jai-Jen, Kuo, Yu-Cheng, Liu, Yu-Chang, Hsu, Fei-Ting, Wang, Hsin-Ell
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Apoptosis - drug effects Carcinoma, Hepatocellular - drug therapy Carcinoma, Hepatocellular - genetics Carcinoma, Hepatocellular - pathology Cell Line, Tumor Cell Proliferation - drug effects Gene Expression Regulation, Neoplastic - drug effects Humans Liver Neoplasms - drug therapy Liver Neoplasms - genetics Liver Neoplasms - pathology MAP Kinase Signaling System - drug effects Mice NF-kappa B - genetics Phenylurea Compounds - administration & dosage Pyridines - administration & dosage Xenograft Model Antitumor Assays
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