Association of genetic ancestry with striatal dopamine D2/D3 receptor availability

Despite ethnic differences in allele frequencies of variants in dopaminergic genes associated with dopamine D2/D3 receptor availability (D2R), no study to date has investigated the relationship between genetic ancestry and striatal D2R. Here, we show that ancestry-informative markers significantly p...

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Veröffentlicht in:	Molecular psychiatry 2018-08, Vol.23 (8), p.1711-1716
Hauptverfasser:	Wiers, C E, Towb, P C, Hodgkinson, C A, Shen, P-H, Freeman, C, Miller, G, Lindgren, E, Shokri-Kojori, E, Demiral, Ş B, Kim, S W, Tomasi, D, Sun, H, Wang, G-J, Goldman, D, Volkow, N D
Format:	Artikel
Sprache:	eng
Schlagworte:	Adolescent Adult Age Factors Analysis Behavioral Sciences Biological Psychology Body mass Brain Mapping Cohort Studies Continental Population Groups - genetics Corpus Striatum - diagnostic imaging Corpus Striatum - metabolism Diagnostic imaging Dopamine Dopamine D2 receptors Dopamine D3 receptors Dopamine receptors Female Future predictions Gene Frequency Genes Humans Male Medicine Medicine & Public Health Metropolitan areas Middle Aged Minority & ethnic groups Neostriatum Nervous system Neurophysiology Neurosciences Pharmacotherapy Phenols (Class of compounds) Polymorphism, Genetic Population studies Positron emission tomography Psychiatry Raclopride Radiopharmaceuticals Receptors, Dopamine D2 - genetics Receptors, Dopamine D2 - metabolism Receptors, Dopamine D3 - genetics Receptors, Dopamine D3 - metabolism Smoking Social class Socioeconomic Factors Socioeconomics Tomography Young Adult
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Zusammenfassung:	Despite ethnic differences in allele frequencies of variants in dopaminergic genes associated with dopamine D2/D3 receptor availability (D2R), no study to date has investigated the relationship between genetic ancestry and striatal D2R. Here, we show that ancestry-informative markers significantly predict dorsal striatal D2R in 117 healthy ethnically diverse residents of the New York metropolitan area using Positron Emission Tomography (PET) with [ 11 C]raclopride ( P
ISSN:	1359-4184 1476-5578
DOI:	10.1038/mp.2017.208