Aster koraiensis Extract and Chlorogenic Acid Inhibit Retinal Angiogenesis in a Mouse Model of Oxygen-Induced Retinopathy
Aster koraiensis extract (AKE) is a standard dietary herbal supplement. Chlorogenic acid (CA) is the major compound present in AKE. Retinal neovascularization is a common pathophysiology of retinopathy of prematurity, diabetic retinopathy, and wet form age-related macular degeneration. In this study...
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| Veröffentlicht in: | Evidence-based complementary and alternative medicine 2018-01, Vol.2018 (2018), p.1-8 |
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| creator | Kim, Chan-Sik Park, Su-Bin Jung, Wookwon Lee, Yun Mi Kim, Junghyun Kim, Jin Sook |
| description | Aster koraiensis extract (AKE) is a standard dietary herbal supplement. Chlorogenic acid (CA) is the major compound present in AKE. Retinal neovascularization is a common pathophysiology of retinopathy of prematurity, diabetic retinopathy, and wet form age-related macular degeneration. In this study, we aimed to evaluate the effects of AKE and CA on retinal neovascularization in a mouse model of oxygen-induced retinopathy (OIR). Vascular endothelial growth factor- (VEGF-) induced tube formation was assayed in human vascular endothelial cells. Experimental retinal neovascularization was induced by exposing C57BL/6 mice to 75% oxygen on postnatal day 7 (P7) and then returning them to normal oxygen pressure on P12. AKE (25 and 50 mg/kg/day) and CA (25 and 50 mg/kg/day) were administered intraperitoneally for 5 days (P12–P16). Retinal flat mounts were prepared to measure the extent of retinal neovascularization at P17. The incubation of human vascular endothelial cells with AKE and CA (1–10 μg/mL) resulted in the inhibition of VEGF-mediated tube formation in a dose-dependent manner. The neovascular area was significantly smaller in AKE or CA-treated mice than in the vehicle-treated mice. These results suggest that AKE is a potent antiangiogenic agent and that its antiangiogenic activity may, in part, be attributable to the bioactive component CA. |
| doi_str_mv | 10.1155/2018/6402650 |
| format | Article |
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Chlorogenic acid (CA) is the major compound present in AKE. Retinal neovascularization is a common pathophysiology of retinopathy of prematurity, diabetic retinopathy, and wet form age-related macular degeneration. In this study, we aimed to evaluate the effects of AKE and CA on retinal neovascularization in a mouse model of oxygen-induced retinopathy (OIR). Vascular endothelial growth factor- (VEGF-) induced tube formation was assayed in human vascular endothelial cells. Experimental retinal neovascularization was induced by exposing C57BL/6 mice to 75% oxygen on postnatal day 7 (P7) and then returning them to normal oxygen pressure on P12. AKE (25 and 50 mg/kg/day) and CA (25 and 50 mg/kg/day) were administered intraperitoneally for 5 days (P12–P16). Retinal flat mounts were prepared to measure the extent of retinal neovascularization at P17. The incubation of human vascular endothelial cells with AKE and CA (1–10 μg/mL) resulted in the inhibition of VEGF-mediated tube formation in a dose-dependent manner. The neovascular area was significantly smaller in AKE or CA-treated mice than in the vehicle-treated mice. These results suggest that AKE is a potent antiangiogenic agent and that its antiangiogenic activity may, in part, be attributable to the bioactive component CA.</description><identifier>ISSN: 1741-427X</identifier><identifier>EISSN: 1741-4288</identifier><identifier>DOI: 10.1155/2018/6402650</identifier><identifier>PMID: 29849715</identifier><language>eng</language><publisher>Cairo, Egypt: Hindawi Publishing Corporation</publisher><subject>Acids ; Age ; Analysis ; Angiogenesis ; Antiangiogenics ; Apoptosis ; Cancer therapies ; Chlorogenic acid ; Diabetes ; Diabetes mellitus ; Diabetic retinopathy ; Dietary supplements ; Endothelial cells ; Endothelium ; Herbal medicine ; Macular degeneration ; Medicine, Botanic ; Medicine, Herbal ; Mice ; Neovascularization ; Oxygen ; Retina ; Retinopathy ; Rodents ; Vascular endothelial growth factor ; Vascularization</subject><ispartof>Evidence-based complementary and alternative medicine, 2018-01, Vol.2018 (2018), p.1-8</ispartof><rights>Copyright © 2018 Junghyun Kim et al.</rights><rights>COPYRIGHT 2018 John Wiley & Sons, Inc.</rights><rights>Copyright © 2018 Junghyun Kim et al.; This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.</rights><rights>Copyright © 2018 Junghyun Kim et al. 2018</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c565t-2a7d769a75ec059fa43c5e9f18b188a99704ee3c5b88c9fb40c8a3a405812d5d3</citedby><cites>FETCH-LOGICAL-c565t-2a7d769a75ec059fa43c5e9f18b188a99704ee3c5b88c9fb40c8a3a405812d5d3</cites><orcidid>0000-0002-8798-8220 ; 0000-0001-7610-9887 ; 0000-0002-9003-2158</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5937502/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5937502/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,885,27924,27925,53791,53793</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/29849715$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><contributor>Garrido, Gabino</contributor><contributor>Gabino Garrido</contributor><creatorcontrib>Kim, Chan-Sik</creatorcontrib><creatorcontrib>Park, Su-Bin</creatorcontrib><creatorcontrib>Jung, Wookwon</creatorcontrib><creatorcontrib>Lee, Yun Mi</creatorcontrib><creatorcontrib>Kim, Junghyun</creatorcontrib><creatorcontrib>Kim, Jin Sook</creatorcontrib><title>Aster koraiensis Extract and Chlorogenic Acid Inhibit Retinal Angiogenesis in a Mouse Model of Oxygen-Induced Retinopathy</title><title>Evidence-based complementary and alternative medicine</title><addtitle>Evid Based Complement Alternat Med</addtitle><description>Aster koraiensis extract (AKE) is a standard dietary herbal supplement. Chlorogenic acid (CA) is the major compound present in AKE. Retinal neovascularization is a common pathophysiology of retinopathy of prematurity, diabetic retinopathy, and wet form age-related macular degeneration. In this study, we aimed to evaluate the effects of AKE and CA on retinal neovascularization in a mouse model of oxygen-induced retinopathy (OIR). Vascular endothelial growth factor- (VEGF-) induced tube formation was assayed in human vascular endothelial cells. Experimental retinal neovascularization was induced by exposing C57BL/6 mice to 75% oxygen on postnatal day 7 (P7) and then returning them to normal oxygen pressure on P12. AKE (25 and 50 mg/kg/day) and CA (25 and 50 mg/kg/day) were administered intraperitoneally for 5 days (P12–P16). Retinal flat mounts were prepared to measure the extent of retinal neovascularization at P17. The incubation of human vascular endothelial cells with AKE and CA (1–10 μg/mL) resulted in the inhibition of VEGF-mediated tube formation in a dose-dependent manner. The neovascular area was significantly smaller in AKE or CA-treated mice than in the vehicle-treated mice. These results suggest that AKE is a potent antiangiogenic agent and that its antiangiogenic activity may, in part, be attributable to the bioactive component CA.</description><subject>Acids</subject><subject>Age</subject><subject>Analysis</subject><subject>Angiogenesis</subject><subject>Antiangiogenics</subject><subject>Apoptosis</subject><subject>Cancer therapies</subject><subject>Chlorogenic acid</subject><subject>Diabetes</subject><subject>Diabetes mellitus</subject><subject>Diabetic retinopathy</subject><subject>Dietary supplements</subject><subject>Endothelial cells</subject><subject>Endothelium</subject><subject>Herbal medicine</subject><subject>Macular degeneration</subject><subject>Medicine, Botanic</subject><subject>Medicine, Herbal</subject><subject>Mice</subject><subject>Neovascularization</subject><subject>Oxygen</subject><subject>Retina</subject><subject>Retinopathy</subject><subject>Rodents</subject><subject>Vascular endothelial growth 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koraiensis Extract and Chlorogenic Acid Inhibit Retinal Angiogenesis in a Mouse Model of Oxygen-Induced Retinopathy</title><author>Kim, Chan-Sik ; Park, Su-Bin ; Jung, Wookwon ; Lee, Yun Mi ; Kim, Junghyun ; Kim, Jin Sook</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c565t-2a7d769a75ec059fa43c5e9f18b188a99704ee3c5b88c9fb40c8a3a405812d5d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2018</creationdate><topic>Acids</topic><topic>Age</topic><topic>Analysis</topic><topic>Angiogenesis</topic><topic>Antiangiogenics</topic><topic>Apoptosis</topic><topic>Cancer therapies</topic><topic>Chlorogenic acid</topic><topic>Diabetes</topic><topic>Diabetes mellitus</topic><topic>Diabetic retinopathy</topic><topic>Dietary supplements</topic><topic>Endothelial cells</topic><topic>Endothelium</topic><topic>Herbal medicine</topic><topic>Macular degeneration</topic><topic>Medicine, Botanic</topic><topic>Medicine, Herbal</topic><topic>Mice</topic><topic>Neovascularization</topic><topic>Oxygen</topic><topic>Retina</topic><topic>Retinopathy</topic><topic>Rodents</topic><topic>Vascular endothelial growth factor</topic><topic>Vascularization</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kim, Chan-Sik</creatorcontrib><creatorcontrib>Park, Su-Bin</creatorcontrib><creatorcontrib>Jung, Wookwon</creatorcontrib><creatorcontrib>Lee, Yun Mi</creatorcontrib><creatorcontrib>Kim, Junghyun</creatorcontrib><creatorcontrib>Kim, Jin Sook</creatorcontrib><collection>الدوريات العلمية والإحصائية - e-Marefa Academic and Statistical Periodicals</collection><collection>معرفة - المحتوى العربي الأكاديمي المتكامل - e-Marefa Academic Complete</collection><collection>Hindawi Publishing Complete</collection><collection>Hindawi Publishing Subscription Journals</collection><collection>Hindawi Publishing Open Access 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Alternat Med</addtitle><date>2018-01-01</date><risdate>2018</risdate><volume>2018</volume><issue>2018</issue><spage>1</spage><epage>8</epage><pages>1-8</pages><issn>1741-427X</issn><eissn>1741-4288</eissn><abstract>Aster koraiensis extract (AKE) is a standard dietary herbal supplement. Chlorogenic acid (CA) is the major compound present in AKE. Retinal neovascularization is a common pathophysiology of retinopathy of prematurity, diabetic retinopathy, and wet form age-related macular degeneration. In this study, we aimed to evaluate the effects of AKE and CA on retinal neovascularization in a mouse model of oxygen-induced retinopathy (OIR). Vascular endothelial growth factor- (VEGF-) induced tube formation was assayed in human vascular endothelial cells. Experimental retinal neovascularization was induced by exposing C57BL/6 mice to 75% oxygen on postnatal day 7 (P7) and then returning them to normal oxygen pressure on P12. AKE (25 and 50 mg/kg/day) and CA (25 and 50 mg/kg/day) were administered intraperitoneally for 5 days (P12–P16). Retinal flat mounts were prepared to measure the extent of retinal neovascularization at P17. The incubation of human vascular endothelial cells with AKE and CA (1–10 μg/mL) resulted in the inhibition of VEGF-mediated tube formation in a dose-dependent manner. The neovascular area was significantly smaller in AKE or CA-treated mice than in the vehicle-treated mice. These results suggest that AKE is a potent antiangiogenic agent and that its antiangiogenic activity may, in part, be attributable to the bioactive component CA.</abstract><cop>Cairo, Egypt</cop><pub>Hindawi Publishing Corporation</pub><pmid>29849715</pmid><doi>10.1155/2018/6402650</doi><tpages>8</tpages><orcidid>https://orcid.org/0000-0002-8798-8220</orcidid><orcidid>https://orcid.org/0000-0001-7610-9887</orcidid><orcidid>https://orcid.org/0000-0002-9003-2158</orcidid><oa>free_for_read</oa></addata></record> |
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| subjects | Acids Age Analysis Angiogenesis Antiangiogenics Apoptosis Cancer therapies Chlorogenic acid Diabetes Diabetes mellitus Diabetic retinopathy Dietary supplements Endothelial cells Endothelium Herbal medicine Macular degeneration Medicine, Botanic Medicine, Herbal Mice Neovascularization Oxygen Retina Retinopathy Rodents Vascular endothelial growth factor Vascularization |
| title | Aster koraiensis Extract and Chlorogenic Acid Inhibit Retinal Angiogenesis in a Mouse Model of Oxygen-Induced Retinopathy |
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