Organoid cystogenesis reveals a critical role of microenvironment in human polycystic kidney disease

Tissue mimics are of great interest in understanding diseases. Here, organoids were developed that resemble polycystic kidney disease cysts and it was demonstrated how material environment and adhesion can affect cystogenesis and disease progression. Polycystic kidney disease (PKD) is a life-threate...

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Veröffentlicht in:	Nature materials 2017-11, Vol.16 (11), p.1112-1119
Hauptverfasser:	Cruz, Nelly M., Song, Xuewen, Czerniecki, Stefan M., Gulieva, Ramila E., Churchill, Angela J., Kim, Yong Kyun, Winston, Kosuke, Tran, Linh M., Diaz, Marco A., Fu, Hongxia, Finn, Laura S., Pei, York, Himmelfarb, Jonathan, Freedman, Benjamin S.
Format:	Artikel
Sprache:	eng
Schlagworte:	631/532/2064 631/80/79/750 639/301/54/994 692/308/1426 Adenosine monophosphate Biomaterials Biomedical materials Cell Line Cellular Microenvironment Condensed Matter Physics Cues Cyclic AMP - metabolism Cysts Defects Gene Expression Regulation Humans Kidney diseases Kidneys letter Materials Science Models, Biological Nanotechnology Optical and Electronic Materials Organoids - metabolism Organoids - pathology Polycystic Kidney Diseases - genetics Polycystic Kidney Diseases - metabolism Polycystic Kidney Diseases - pathology Polycystic ovary syndrome Sodium Stem cells Surgical implants TRPP Cation Channels - biosynthesis TRPP Cation Channels - genetics
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