Biased signalling: from simple switches to allosteric microprocessors

Key Points G protein-coupled receptors (GPCRs) adopt multiple conformational states that can activate or block distinct intracellular signalling pathways, such as those regulated by heterotrimeric G proteins or β-arrestins. Different agonists for the same receptor can stabilize distinct GPCR conform...

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Veröffentlicht in:	Nature reviews. Drug discovery 2018-04, Vol.17 (4), p.243-260
Hauptverfasser:	Smith, Jeffrey S., Lefkowitz, Robert J., Rajagopal, Sudarshan
Format:	Artikel
Sprache:	eng
Schlagworte:	631/154/436/2387 631/45/776/1178 Allosteric Regulation - drug effects Animals beta-Arrestins - metabolism Biomedicine Biotechnology Cancer Research Cellular signal transduction Drug development Drug Development - methods G proteins GTP-Binding Proteins - metabolism Humans Ligands Medicinal Chemistry Microcomputers Microprocessors Molecular Medicine Pharmaceutical Preparations - administration & dosage Pharmacology/Toxicology Proteins Receptors, G-Protein-Coupled - metabolism review-article Signal Transduction - drug effects
Online-Zugang:	Volltext
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