Functional Compromise Cohort Study (FCCS): Sarcopenia is a Strong Predictor of Mortality in the Intensive Care Unit
Background Functional compromise in elderly patients is considered to be a significant contributing factor in increased postoperative morbidity and mortality. It is described as a state of reduced physiologic reserves including, e.g., sarcopenia, cachexia, malnutrition and frailty with increased sus...
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| Veröffentlicht in: | World journal of surgery 2018-06, Vol.42 (6), p.1733-1741 |
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| creator | de Hoogt, P. A. Reisinger, K. W. Tegels, J. J. W. Bosmans, J. W. A. M. Tijssen, F. Stoot, J. H. M. B. |
| description | Background
Functional compromise in elderly patients is considered to be a significant contributing factor in increased postoperative morbidity and mortality. It is described as a state of reduced physiologic reserves including, e.g., sarcopenia, cachexia, malnutrition and frailty with increased susceptibility to adverse health outcomes. Aim of this study was to investigate the association of sarcopenia with mortality in ICU patients.
Methods
A retrospective analysis of a total of 687 patients admitted to the ICU from January 2013 until December 2014 was performed. Indirect measurements of functional compromise in these patients were conducted. Sarcopenia was assessed using the L3 muscle index by using Osirix© on computed tomography scans. Groningen Frailty Indicator (GFI) and Short Nutritional Assessment Questionnaire (SNAQ) scores were extracted from the digital patient filing system and were used to assess frailty and nutritional status. These factors were analyzed using logistic regression analysis as predictor for in-hospital mortality and 6-month mortality, which was the primary endpoint along with other secondary outcome measures.
Results
Age was an independent predictor of in-hospital mortality, OR 1.043 (95% CI 1.030–1.057,
p
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| doi_str_mv | 10.1007/s00268-017-4386-8 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_5934455</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>1982841204</sourcerecordid><originalsourceid>FETCH-LOGICAL-c5202-29b992b41324db901ef4c261ce40b6ca5bb4e0aa32e861f1cd2761df4fe25c583</originalsourceid><addsrcrecordid>eNqFkV9rFDEUxYModlv9AL5IwJf6MJp_k0l8KOjgaqWisBYfQyaT2U2ZTdYk07Lf3qxTSxXEp3vh_s7h3nsAeIbRK4xQ8zohRLioEG4qRgWvxAOwwIySilBCH4IFopyVHtMjcJzSFSogR_wxOCKSiJojuQBpOXmTXfB6hG3Y7mLYumRLuwkxw1We-j08Xbbt6uUbuNLRhJ31TkOXoC7TGPwafo22dyaHCMMAPxeZHl3eQ-dh3lh47rP1yV0XTx0tvPQuPwGPBj0m-_S2noDL5ftv7cfq4suH8_btRWVqgsoRspOSdAxTwvpOImwHZgjHxjLUcaPrrmMWaU2JFRwP2PSk4bgf2GBJbWpBT8DZ7Lubuq3tjfU56lHtotvquFdBO_XnxLuNWodrVUvKWF0Xg9Nbgxh-TDZlVZ5j7Dhqb8OUFJaCCIYJYgV98Rd6FaZYvvqLwrQRSB4oPFMmhpSiHe6WwUgdIlVzpKokpQ6RqsMVz-9fcaf4nWEB5AzcuNHu_--ovn9avVsi0UhStGTWpiLzaxvvrf3PjX4C8Oy9eA</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1981378094</pqid></control><display><type>article</type><title>Functional Compromise Cohort Study (FCCS): Sarcopenia is a Strong Predictor of Mortality in the Intensive Care Unit</title><source>Springer Nature - Complete Springer Journals</source><source>Wiley Online Library Journals Frontfile Complete</source><creator>de Hoogt, P. A. ; Reisinger, K. W. ; Tegels, J. J. W. ; Bosmans, J. W. A. M. ; Tijssen, F. ; Stoot, J. H. M. B.</creator><creatorcontrib>de Hoogt, P. A. ; Reisinger, K. W. ; Tegels, J. J. W. ; Bosmans, J. W. A. M. ; Tijssen, F. ; Stoot, J. H. M. B.</creatorcontrib><description>Background
Functional compromise in elderly patients is considered to be a significant contributing factor in increased postoperative morbidity and mortality. It is described as a state of reduced physiologic reserves including, e.g., sarcopenia, cachexia, malnutrition and frailty with increased susceptibility to adverse health outcomes. Aim of this study was to investigate the association of sarcopenia with mortality in ICU patients.
Methods
A retrospective analysis of a total of 687 patients admitted to the ICU from January 2013 until December 2014 was performed. Indirect measurements of functional compromise in these patients were conducted. Sarcopenia was assessed using the L3 muscle index by using Osirix© on computed tomography scans. Groningen Frailty Indicator (GFI) and Short Nutritional Assessment Questionnaire (SNAQ) scores were extracted from the digital patient filing system and were used to assess frailty and nutritional status. These factors were analyzed using logistic regression analysis as predictor for in-hospital mortality and 6-month mortality, which was the primary endpoint along with other secondary outcome measures.
Results
Age was an independent predictor of in-hospital mortality, OR 1.043 (95% CI 1.030–1.057,
p
< 0.001). Analysis of sarcopenia showed OR 2.361 (95% CI 1.138–4.895,
p
= 0.021), for GFI OR 1.012 (95% CI 0.919–1.113,
p
= 0.811) and for SNAQ OR 1.262 (95% CI 1.091–1.460,
p
= 0.002).
Conclusion
This study shows a promising role for the sarcopenia score as a predictor of mortality on the ICU, based upon CT imaging at L3 level and SNAQ score. Further research is necessary to test this in larger cohorts and to develop a possible instrument to predict mortality in the intensive care unit.</description><identifier>ISSN: 0364-2313</identifier><identifier>EISSN: 1432-2323</identifier><identifier>DOI: 10.1007/s00268-017-4386-8</identifier><identifier>PMID: 29285609</identifier><language>eng</language><publisher>Cham: Springer International Publishing</publisher><subject>Abdominal Surgery ; Cachexia ; Cardiac Surgery ; Cohort analysis ; Computed tomography ; General Surgery ; Geriatrics ; Malnutrition ; Medicine ; Medicine & Public Health ; Morbidity ; Mortality ; Muscles ; Nutritional status ; Older people ; Original Scientific Report ; Patients ; Regression analysis ; Sarcopenia ; Surgery ; Thoracic Surgery ; Vascular Surgery</subject><ispartof>World journal of surgery, 2018-06, Vol.42 (6), p.1733-1741</ispartof><rights>The Author(s) 2017</rights><rights>2018 The Author(s)</rights><rights>World Journal of Surgery is a copyright of Springer, (2017). All Rights Reserved.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c5202-29b992b41324db901ef4c261ce40b6ca5bb4e0aa32e861f1cd2761df4fe25c583</citedby><cites>FETCH-LOGICAL-c5202-29b992b41324db901ef4c261ce40b6ca5bb4e0aa32e861f1cd2761df4fe25c583</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s00268-017-4386-8$$EPDF$$P50$$Gspringer$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s00268-017-4386-8$$EHTML$$P50$$Gspringer$$Hfree_for_read</linktohtml><link.rule.ids>230,314,776,780,881,1411,27903,27904,41467,42536,45553,45554,51297</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/29285609$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>de Hoogt, P. A.</creatorcontrib><creatorcontrib>Reisinger, K. W.</creatorcontrib><creatorcontrib>Tegels, J. J. W.</creatorcontrib><creatorcontrib>Bosmans, J. W. A. M.</creatorcontrib><creatorcontrib>Tijssen, F.</creatorcontrib><creatorcontrib>Stoot, J. H. M. B.</creatorcontrib><title>Functional Compromise Cohort Study (FCCS): Sarcopenia is a Strong Predictor of Mortality in the Intensive Care Unit</title><title>World journal of surgery</title><addtitle>World J Surg</addtitle><addtitle>World J Surg</addtitle><description>Background
Functional compromise in elderly patients is considered to be a significant contributing factor in increased postoperative morbidity and mortality. It is described as a state of reduced physiologic reserves including, e.g., sarcopenia, cachexia, malnutrition and frailty with increased susceptibility to adverse health outcomes. Aim of this study was to investigate the association of sarcopenia with mortality in ICU patients.
Methods
A retrospective analysis of a total of 687 patients admitted to the ICU from January 2013 until December 2014 was performed. Indirect measurements of functional compromise in these patients were conducted. Sarcopenia was assessed using the L3 muscle index by using Osirix© on computed tomography scans. Groningen Frailty Indicator (GFI) and Short Nutritional Assessment Questionnaire (SNAQ) scores were extracted from the digital patient filing system and were used to assess frailty and nutritional status. These factors were analyzed using logistic regression analysis as predictor for in-hospital mortality and 6-month mortality, which was the primary endpoint along with other secondary outcome measures.
Results
Age was an independent predictor of in-hospital mortality, OR 1.043 (95% CI 1.030–1.057,
p
< 0.001). Analysis of sarcopenia showed OR 2.361 (95% CI 1.138–4.895,
p
= 0.021), for GFI OR 1.012 (95% CI 0.919–1.113,
p
= 0.811) and for SNAQ OR 1.262 (95% CI 1.091–1.460,
p
= 0.002).
Conclusion
This study shows a promising role for the sarcopenia score as a predictor of mortality on the ICU, based upon CT imaging at L3 level and SNAQ score. Further research is necessary to test this in larger cohorts and to develop a possible instrument to predict mortality in the intensive care unit.</description><subject>Abdominal Surgery</subject><subject>Cachexia</subject><subject>Cardiac Surgery</subject><subject>Cohort analysis</subject><subject>Computed tomography</subject><subject>General Surgery</subject><subject>Geriatrics</subject><subject>Malnutrition</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Morbidity</subject><subject>Mortality</subject><subject>Muscles</subject><subject>Nutritional status</subject><subject>Older people</subject><subject>Original Scientific Report</subject><subject>Patients</subject><subject>Regression analysis</subject><subject>Sarcopenia</subject><subject>Surgery</subject><subject>Thoracic Surgery</subject><subject>Vascular Surgery</subject><issn>0364-2313</issn><issn>1432-2323</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><sourceid>C6C</sourceid><sourceid>24P</sourceid><sourceid>BENPR</sourceid><recordid>eNqFkV9rFDEUxYModlv9AL5IwJf6MJp_k0l8KOjgaqWisBYfQyaT2U2ZTdYk07Lf3qxTSxXEp3vh_s7h3nsAeIbRK4xQ8zohRLioEG4qRgWvxAOwwIySilBCH4IFopyVHtMjcJzSFSogR_wxOCKSiJojuQBpOXmTXfB6hG3Y7mLYumRLuwkxw1We-j08Xbbt6uUbuNLRhJ31TkOXoC7TGPwafo22dyaHCMMAPxeZHl3eQ-dh3lh47rP1yV0XTx0tvPQuPwGPBj0m-_S2noDL5ftv7cfq4suH8_btRWVqgsoRspOSdAxTwvpOImwHZgjHxjLUcaPrrmMWaU2JFRwP2PSk4bgf2GBJbWpBT8DZ7Lubuq3tjfU56lHtotvquFdBO_XnxLuNWodrVUvKWF0Xg9Nbgxh-TDZlVZ5j7Dhqb8OUFJaCCIYJYgV98Rd6FaZYvvqLwrQRSB4oPFMmhpSiHe6WwUgdIlVzpKokpQ6RqsMVz-9fcaf4nWEB5AzcuNHu_--ovn9avVsi0UhStGTWpiLzaxvvrf3PjX4C8Oy9eA</recordid><startdate>201806</startdate><enddate>201806</enddate><creator>de Hoogt, P. A.</creator><creator>Reisinger, K. W.</creator><creator>Tegels, J. J. W.</creator><creator>Bosmans, J. W. A. M.</creator><creator>Tijssen, F.</creator><creator>Stoot, J. H. M. B.</creator><general>Springer International Publishing</general><general>Springer Nature B.V</general><scope>C6C</scope><scope>24P</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QO</scope><scope>7T5</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FD</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>H94</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>P64</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>201806</creationdate><title>Functional Compromise Cohort Study (FCCS): Sarcopenia is a Strong Predictor of Mortality in the Intensive Care Unit</title><author>de Hoogt, P. A. ; Reisinger, K. W. ; Tegels, J. J. W. ; Bosmans, J. W. A. M. ; Tijssen, F. ; Stoot, J. H. M. B.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c5202-29b992b41324db901ef4c261ce40b6ca5bb4e0aa32e861f1cd2761df4fe25c583</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2018</creationdate><topic>Abdominal Surgery</topic><topic>Cachexia</topic><topic>Cardiac Surgery</topic><topic>Cohort analysis</topic><topic>Computed tomography</topic><topic>General Surgery</topic><topic>Geriatrics</topic><topic>Malnutrition</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Morbidity</topic><topic>Mortality</topic><topic>Muscles</topic><topic>Nutritional status</topic><topic>Older people</topic><topic>Original Scientific Report</topic><topic>Patients</topic><topic>Regression analysis</topic><topic>Sarcopenia</topic><topic>Surgery</topic><topic>Thoracic Surgery</topic><topic>Vascular Surgery</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>de Hoogt, P. A.</creatorcontrib><creatorcontrib>Reisinger, K. W.</creatorcontrib><creatorcontrib>Tegels, J. J. W.</creatorcontrib><creatorcontrib>Bosmans, J. W. A. M.</creatorcontrib><creatorcontrib>Tijssen, F.</creatorcontrib><creatorcontrib>Stoot, J. H. M. B.</creatorcontrib><collection>Springer Nature OA Free Journals</collection><collection>Wiley Online Library Open Access</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Biotechnology Research Abstracts</collection><collection>Immunology Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Technology Research Database</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>World journal of surgery</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>de Hoogt, P. A.</au><au>Reisinger, K. W.</au><au>Tegels, J. J. W.</au><au>Bosmans, J. W. A. M.</au><au>Tijssen, F.</au><au>Stoot, J. H. M. B.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Functional Compromise Cohort Study (FCCS): Sarcopenia is a Strong Predictor of Mortality in the Intensive Care Unit</atitle><jtitle>World journal of surgery</jtitle><stitle>World J Surg</stitle><addtitle>World J Surg</addtitle><date>2018-06</date><risdate>2018</risdate><volume>42</volume><issue>6</issue><spage>1733</spage><epage>1741</epage><pages>1733-1741</pages><issn>0364-2313</issn><eissn>1432-2323</eissn><abstract>Background
Functional compromise in elderly patients is considered to be a significant contributing factor in increased postoperative morbidity and mortality. It is described as a state of reduced physiologic reserves including, e.g., sarcopenia, cachexia, malnutrition and frailty with increased susceptibility to adverse health outcomes. Aim of this study was to investigate the association of sarcopenia with mortality in ICU patients.
Methods
A retrospective analysis of a total of 687 patients admitted to the ICU from January 2013 until December 2014 was performed. Indirect measurements of functional compromise in these patients were conducted. Sarcopenia was assessed using the L3 muscle index by using Osirix© on computed tomography scans. Groningen Frailty Indicator (GFI) and Short Nutritional Assessment Questionnaire (SNAQ) scores were extracted from the digital patient filing system and were used to assess frailty and nutritional status. These factors were analyzed using logistic regression analysis as predictor for in-hospital mortality and 6-month mortality, which was the primary endpoint along with other secondary outcome measures.
Results
Age was an independent predictor of in-hospital mortality, OR 1.043 (95% CI 1.030–1.057,
p
< 0.001). Analysis of sarcopenia showed OR 2.361 (95% CI 1.138–4.895,
p
= 0.021), for GFI OR 1.012 (95% CI 0.919–1.113,
p
= 0.811) and for SNAQ OR 1.262 (95% CI 1.091–1.460,
p
= 0.002).
Conclusion
This study shows a promising role for the sarcopenia score as a predictor of mortality on the ICU, based upon CT imaging at L3 level and SNAQ score. Further research is necessary to test this in larger cohorts and to develop a possible instrument to predict mortality in the intensive care unit.</abstract><cop>Cham</cop><pub>Springer International Publishing</pub><pmid>29285609</pmid><doi>10.1007/s00268-017-4386-8</doi><tpages>9</tpages><oa>free_for_read</oa></addata></record> |
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| source | Springer Nature - Complete Springer Journals; Wiley Online Library Journals Frontfile Complete |
| subjects | Abdominal Surgery Cachexia Cardiac Surgery Cohort analysis Computed tomography General Surgery Geriatrics Malnutrition Medicine Medicine & Public Health Morbidity Mortality Muscles Nutritional status Older people Original Scientific Report Patients Regression analysis Sarcopenia Surgery Thoracic Surgery Vascular Surgery |
| title | Functional Compromise Cohort Study (FCCS): Sarcopenia is a Strong Predictor of Mortality in the Intensive Care Unit |
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