Prenatal traffic‐related air pollution exposures, cord blood adipokines and infant weight
Summary Objective Studies suggest that prenatal exposure to traffic‐related air pollution (TRAP) may contribute to childhood obesity. While exact mechanisms for this association are unknown, circulating adipokines are hypothesized to contribute to early‐life weight gain. Methods The Maternal and Chi...
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| Veröffentlicht in: | Pediatric obesity 2018-06, Vol.13 (6), p.348-356 |
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| creator | Alderete, T. L. Song, A. Y. Bastain, T. Habre, R. Toledo‐Corral, C. M. Salam, M. T. Lurmann, F. Gilliland, F. D. Breton, C. V. |
| description | Summary
Objective
Studies suggest that prenatal exposure to traffic‐related air pollution (TRAP) may contribute to childhood obesity. While exact mechanisms for this association are unknown, circulating adipokines are hypothesized to contribute to early‐life weight gain.
Methods
The Maternal and Child Health Study birth cohort included 136 women from the Los Angeles County + University of Southern California Medical Center. This study estimated prenatal residential TRAP exposure and used linear regression analysis to examine associations between adipokines with TRAP exposure and infant weight change (birth to 6 months).
Results
A one standard deviation (1‐SD: 2 ppb) increase in prenatal non‐freeway nitrogen oxides was associated with 33% (P = 0.01) higher leptin and 9% higher high molecular weight adiponectin levels (P = 0.07) in cord blood. Leptin levels were 71% higher in mothers who lived 300 m from major roadways (P = 0.03). A 1‐SD (10 ng mL−1) increase in leptin was associated with a significant increase in infant weight change in female infants (0.62 kg, P = 0.02) but not male infants (0.11 kg, P = 0.48).
Conclusions
Higher TRAP exposures were associated with higher cord blood levels of leptin and high molecular weight adiponectin. These adipokines were associated with increased infant weight change in female infants, which may have implications for future obesity risk. |
| doi_str_mv | 10.1111/ijpo.12248 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_5934325</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2047422792</sourcerecordid><originalsourceid>FETCH-LOGICAL-c5148-db5799e02e3b2e91bf35bfe823a9084a35ff0d7f32cffbb5367daa91523277463</originalsourceid><addsrcrecordid>eNp9kctKBDEQRYMoKurGD5CAO3E0j35lI4j4RHAWunIR0t2VmYw9SZt0-9j5CX6jX2LG0UE31iYFOdy6VRehbUoOaKxDM2ndAWUsKZbQOiNJPsg4JcuLnrA1tBXChMTKCM1IsorWmCCiyIVYR_dDD1Z1qsGdV1qb6uPt3UOjOqixMh63rmn6zjiL4aV1ofcQ9nHlfI3LxrnI1KZ1D8ZCwMrW2FitbIefwYzG3SZa0aoJsPX9bqC7s9Pbk4vB9c355cnx9aBKaVIM6jKNVoAw4CUDQUvN01JDwbgSpEgUT7Umda45q7Quy5Rnea2UoCnjLM-TjG-go7lu25dTqCuwcZdGtt5MlX-VThn598easRy5J5kKnnCWRoHdbwHvHnsInZy43tvoWc6umDCWCxapvTlVeReCB72YQImcZSFnWcivLCK889vTAv25fAToHHg2Dbz-IyUvr4Y3c9FPJv6XOQ</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2047422792</pqid></control><display><type>article</type><title>Prenatal traffic‐related air pollution exposures, cord blood adipokines and infant weight</title><source>MEDLINE</source><source>Wiley Online Library Journals Frontfile Complete</source><creator>Alderete, T. L. ; Song, A. Y. ; Bastain, T. ; Habre, R. ; Toledo‐Corral, C. M. ; Salam, M. T. ; Lurmann, F. ; Gilliland, F. D. ; Breton, C. V.</creator><creatorcontrib>Alderete, T. L. ; Song, A. Y. ; Bastain, T. ; Habre, R. ; Toledo‐Corral, C. M. ; Salam, M. T. ; Lurmann, F. ; Gilliland, F. D. ; Breton, C. V.</creatorcontrib><description>Summary
Objective
Studies suggest that prenatal exposure to traffic‐related air pollution (TRAP) may contribute to childhood obesity. While exact mechanisms for this association are unknown, circulating adipokines are hypothesized to contribute to early‐life weight gain.
Methods
The Maternal and Child Health Study birth cohort included 136 women from the Los Angeles County + University of Southern California Medical Center. This study estimated prenatal residential TRAP exposure and used linear regression analysis to examine associations between adipokines with TRAP exposure and infant weight change (birth to 6 months).
Results
A one standard deviation (1‐SD: 2 ppb) increase in prenatal non‐freeway nitrogen oxides was associated with 33% (P = 0.01) higher leptin and 9% higher high molecular weight adiponectin levels (P = 0.07) in cord blood. Leptin levels were 71% higher in mothers who lived <75 m than those living >300 m from major roadways (P = 0.03). A 1‐SD (10 ng mL−1) increase in leptin was associated with a significant increase in infant weight change in female infants (0.62 kg, P = 0.02) but not male infants (0.11 kg, P = 0.48).
Conclusions
Higher TRAP exposures were associated with higher cord blood levels of leptin and high molecular weight adiponectin. These adipokines were associated with increased infant weight change in female infants, which may have implications for future obesity risk.</description><identifier>ISSN: 2047-6302</identifier><identifier>EISSN: 2047-6310</identifier><identifier>DOI: 10.1111/ijpo.12248</identifier><identifier>PMID: 29098799</identifier><language>eng</language><publisher>England: Wiley Subscription Services, Inc</publisher><subject>Adipokines - blood ; Adult ; Air Pollutants - adverse effects ; Air Pollutants - analysis ; Air pollution ; Air Pollution - adverse effects ; Air Pollution - analysis ; Babies ; Baby foods ; Body Weight - physiology ; California ; Child ; Childrens health ; cord blood ; Female ; Fetal Blood - metabolism ; high molecular weight adiponectin ; Humans ; Infant ; Infant, Newborn ; leptin ; Linear Models ; Male ; Maternal & child health ; Mothers ; Obesity ; Pediatric Obesity - etiology ; Pediatrics ; Pregnancy ; Prenatal exposure ; Prenatal Exposure Delayed Effects - blood ; Traffic-Related Pollution - adverse effects ; Traffic-Related Pollution - analysis ; Weight Gain - physiology</subject><ispartof>Pediatric obesity, 2018-06, Vol.13 (6), p.348-356</ispartof><rights>2017 World Obesity Federation</rights><rights>2017 World Obesity Federation.</rights><rights>2018 World Obesity Federation</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c5148-db5799e02e3b2e91bf35bfe823a9084a35ff0d7f32cffbb5367daa91523277463</citedby><cites>FETCH-LOGICAL-c5148-db5799e02e3b2e91bf35bfe823a9084a35ff0d7f32cffbb5367daa91523277463</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fijpo.12248$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fijpo.12248$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>230,314,776,780,881,1411,27901,27902,45550,45551</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/29098799$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Alderete, T. L.</creatorcontrib><creatorcontrib>Song, A. Y.</creatorcontrib><creatorcontrib>Bastain, T.</creatorcontrib><creatorcontrib>Habre, R.</creatorcontrib><creatorcontrib>Toledo‐Corral, C. M.</creatorcontrib><creatorcontrib>Salam, M. T.</creatorcontrib><creatorcontrib>Lurmann, F.</creatorcontrib><creatorcontrib>Gilliland, F. D.</creatorcontrib><creatorcontrib>Breton, C. V.</creatorcontrib><title>Prenatal traffic‐related air pollution exposures, cord blood adipokines and infant weight</title><title>Pediatric obesity</title><addtitle>Pediatr Obes</addtitle><description>Summary
Objective
Studies suggest that prenatal exposure to traffic‐related air pollution (TRAP) may contribute to childhood obesity. While exact mechanisms for this association are unknown, circulating adipokines are hypothesized to contribute to early‐life weight gain.
Methods
The Maternal and Child Health Study birth cohort included 136 women from the Los Angeles County + University of Southern California Medical Center. This study estimated prenatal residential TRAP exposure and used linear regression analysis to examine associations between adipokines with TRAP exposure and infant weight change (birth to 6 months).
Results
A one standard deviation (1‐SD: 2 ppb) increase in prenatal non‐freeway nitrogen oxides was associated with 33% (P = 0.01) higher leptin and 9% higher high molecular weight adiponectin levels (P = 0.07) in cord blood. Leptin levels were 71% higher in mothers who lived <75 m than those living >300 m from major roadways (P = 0.03). A 1‐SD (10 ng mL−1) increase in leptin was associated with a significant increase in infant weight change in female infants (0.62 kg, P = 0.02) but not male infants (0.11 kg, P = 0.48).
Conclusions
Higher TRAP exposures were associated with higher cord blood levels of leptin and high molecular weight adiponectin. These adipokines were associated with increased infant weight change in female infants, which may have implications for future obesity risk.</description><subject>Adipokines - blood</subject><subject>Adult</subject><subject>Air Pollutants - adverse effects</subject><subject>Air Pollutants - analysis</subject><subject>Air pollution</subject><subject>Air Pollution - adverse effects</subject><subject>Air Pollution - analysis</subject><subject>Babies</subject><subject>Baby foods</subject><subject>Body Weight - physiology</subject><subject>California</subject><subject>Child</subject><subject>Childrens health</subject><subject>cord blood</subject><subject>Female</subject><subject>Fetal Blood - metabolism</subject><subject>high molecular weight adiponectin</subject><subject>Humans</subject><subject>Infant</subject><subject>Infant, Newborn</subject><subject>leptin</subject><subject>Linear Models</subject><subject>Male</subject><subject>Maternal & child health</subject><subject>Mothers</subject><subject>Obesity</subject><subject>Pediatric Obesity - etiology</subject><subject>Pediatrics</subject><subject>Pregnancy</subject><subject>Prenatal exposure</subject><subject>Prenatal Exposure Delayed Effects - blood</subject><subject>Traffic-Related Pollution - adverse effects</subject><subject>Traffic-Related Pollution - analysis</subject><subject>Weight Gain - physiology</subject><issn>2047-6302</issn><issn>2047-6310</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kctKBDEQRYMoKurGD5CAO3E0j35lI4j4RHAWunIR0t2VmYw9SZt0-9j5CX6jX2LG0UE31iYFOdy6VRehbUoOaKxDM2ndAWUsKZbQOiNJPsg4JcuLnrA1tBXChMTKCM1IsorWmCCiyIVYR_dDD1Z1qsGdV1qb6uPt3UOjOqixMh63rmn6zjiL4aV1ofcQ9nHlfI3LxrnI1KZ1D8ZCwMrW2FitbIefwYzG3SZa0aoJsPX9bqC7s9Pbk4vB9c355cnx9aBKaVIM6jKNVoAw4CUDQUvN01JDwbgSpEgUT7Umda45q7Quy5Rnea2UoCnjLM-TjG-go7lu25dTqCuwcZdGtt5MlX-VThn598easRy5J5kKnnCWRoHdbwHvHnsInZy43tvoWc6umDCWCxapvTlVeReCB72YQImcZSFnWcivLCK889vTAv25fAToHHg2Dbz-IyUvr4Y3c9FPJv6XOQ</recordid><startdate>201806</startdate><enddate>201806</enddate><creator>Alderete, T. L.</creator><creator>Song, A. Y.</creator><creator>Bastain, T.</creator><creator>Habre, R.</creator><creator>Toledo‐Corral, C. M.</creator><creator>Salam, M. T.</creator><creator>Lurmann, F.</creator><creator>Gilliland, F. D.</creator><creator>Breton, C. V.</creator><general>Wiley Subscription Services, Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>K9.</scope><scope>5PM</scope></search><sort><creationdate>201806</creationdate><title>Prenatal traffic‐related air pollution exposures, cord blood adipokines and infant weight</title><author>Alderete, T. L. ; Song, A. Y. ; Bastain, T. ; Habre, R. ; Toledo‐Corral, C. M. ; Salam, M. T. ; Lurmann, F. ; Gilliland, F. D. ; Breton, C. V.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c5148-db5799e02e3b2e91bf35bfe823a9084a35ff0d7f32cffbb5367daa91523277463</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2018</creationdate><topic>Adipokines - blood</topic><topic>Adult</topic><topic>Air Pollutants - adverse effects</topic><topic>Air Pollutants - analysis</topic><topic>Air pollution</topic><topic>Air Pollution - adverse effects</topic><topic>Air Pollution - analysis</topic><topic>Babies</topic><topic>Baby foods</topic><topic>Body Weight - physiology</topic><topic>California</topic><topic>Child</topic><topic>Childrens health</topic><topic>cord blood</topic><topic>Female</topic><topic>Fetal Blood - metabolism</topic><topic>high molecular weight adiponectin</topic><topic>Humans</topic><topic>Infant</topic><topic>Infant, Newborn</topic><topic>leptin</topic><topic>Linear Models</topic><topic>Male</topic><topic>Maternal & child health</topic><topic>Mothers</topic><topic>Obesity</topic><topic>Pediatric Obesity - etiology</topic><topic>Pediatrics</topic><topic>Pregnancy</topic><topic>Prenatal exposure</topic><topic>Prenatal Exposure Delayed Effects - blood</topic><topic>Traffic-Related Pollution - adverse effects</topic><topic>Traffic-Related Pollution - analysis</topic><topic>Weight Gain - physiology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Alderete, T. L.</creatorcontrib><creatorcontrib>Song, A. Y.</creatorcontrib><creatorcontrib>Bastain, T.</creatorcontrib><creatorcontrib>Habre, R.</creatorcontrib><creatorcontrib>Toledo‐Corral, C. M.</creatorcontrib><creatorcontrib>Salam, M. T.</creatorcontrib><creatorcontrib>Lurmann, F.</creatorcontrib><creatorcontrib>Gilliland, F. D.</creatorcontrib><creatorcontrib>Breton, C. V.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Pediatric obesity</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Alderete, T. L.</au><au>Song, A. Y.</au><au>Bastain, T.</au><au>Habre, R.</au><au>Toledo‐Corral, C. M.</au><au>Salam, M. T.</au><au>Lurmann, F.</au><au>Gilliland, F. D.</au><au>Breton, C. V.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Prenatal traffic‐related air pollution exposures, cord blood adipokines and infant weight</atitle><jtitle>Pediatric obesity</jtitle><addtitle>Pediatr Obes</addtitle><date>2018-06</date><risdate>2018</risdate><volume>13</volume><issue>6</issue><spage>348</spage><epage>356</epage><pages>348-356</pages><issn>2047-6302</issn><eissn>2047-6310</eissn><abstract>Summary
Objective
Studies suggest that prenatal exposure to traffic‐related air pollution (TRAP) may contribute to childhood obesity. While exact mechanisms for this association are unknown, circulating adipokines are hypothesized to contribute to early‐life weight gain.
Methods
The Maternal and Child Health Study birth cohort included 136 women from the Los Angeles County + University of Southern California Medical Center. This study estimated prenatal residential TRAP exposure and used linear regression analysis to examine associations between adipokines with TRAP exposure and infant weight change (birth to 6 months).
Results
A one standard deviation (1‐SD: 2 ppb) increase in prenatal non‐freeway nitrogen oxides was associated with 33% (P = 0.01) higher leptin and 9% higher high molecular weight adiponectin levels (P = 0.07) in cord blood. Leptin levels were 71% higher in mothers who lived <75 m than those living >300 m from major roadways (P = 0.03). A 1‐SD (10 ng mL−1) increase in leptin was associated with a significant increase in infant weight change in female infants (0.62 kg, P = 0.02) but not male infants (0.11 kg, P = 0.48).
Conclusions
Higher TRAP exposures were associated with higher cord blood levels of leptin and high molecular weight adiponectin. These adipokines were associated with increased infant weight change in female infants, which may have implications for future obesity risk.</abstract><cop>England</cop><pub>Wiley Subscription Services, Inc</pub><pmid>29098799</pmid><doi>10.1111/ijpo.12248</doi><tpages>9</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Pediatric obesity, 2018-06, Vol.13 (6), p.348-356 |
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| source | MEDLINE; Wiley Online Library Journals Frontfile Complete |
| subjects | Adipokines - blood Adult Air Pollutants - adverse effects Air Pollutants - analysis Air pollution Air Pollution - adverse effects Air Pollution - analysis Babies Baby foods Body Weight - physiology California Child Childrens health cord blood Female Fetal Blood - metabolism high molecular weight adiponectin Humans Infant Infant, Newborn leptin Linear Models Male Maternal & child health Mothers Obesity Pediatric Obesity - etiology Pediatrics Pregnancy Prenatal exposure Prenatal Exposure Delayed Effects - blood Traffic-Related Pollution - adverse effects Traffic-Related Pollution - analysis Weight Gain - physiology |
| title | Prenatal traffic‐related air pollution exposures, cord blood adipokines and infant weight |
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