DNA methylation of the BRD2 promoter is associated with juvenile myoclonic epilepsy in Caucasians

Summary Objective Juvenile myoclonic epilepsy (JME) is a common adolescent‐onset genetic generalized epilepsy (GGE) syndrome. Multiple linkage and association studies have found that BRD2 influences the expression of JME. The BRD2‐JME connection is further corroborated by our murine model; Brd2 hapl...

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Veröffentlicht in:	Epilepsia (Copenhagen) 2018-05, Vol.59 (5), p.1011-1019
Hauptverfasser:	Pathak, Shilpa, Miller, James, Morris, Emily C., Stewart, William C. L., Greenberg, David A.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animal models association analysis BRD2 Child CpG islands DNA methylation DNA Methylation - genetics DNMT1 protein Epilepsies, Myoclonic - genetics Epilepsy ethnicity European Continental Ancestry Group - genetics Female gene expression Gene silencing genetic generalized epilepsy Haploinsufficiency Humans juvenile myoclonic epilepsy linkage analysis Male Minority & ethnic groups Mutation Promoter Regions, Genetic - genetics Protein-Serine-Threonine Kinases - genetics Seizures Single-nucleotide polymorphism Transcription Transcription Factors
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