Plasma Metal Concentrations and Incident Coronary Heart Disease in Chinese Adults: The Dongfeng-Tongji Cohort
Circulating metals from both the natural environment and pollution have been linked to cardiovascular disease. However, few prospective studies have investigated the associations between exposure to multiple metals and incident coronary heart disease (CHD). We conducted a nested case-control study i...
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| Veröffentlicht in: | Environmental health perspectives 2017-10, Vol.125 (10), p.107007 |
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| creator | Yuan, Yu Xiao, Yang Feng, Wei Liu, Yiyi Yu, Yanqiu Zhou, Lue Qiu, Gaokun Wang, Hao Liu, Bing Liu, Kang Yang, Handong Li, Xiulou Min, Xinwen Zhang, Ce Xu, Chengwei Zhang, Xiaomin He, Meian Hu, Frank B Pan, An Wu, Tangchun |
| description | Circulating metals from both the natural environment and pollution have been linked to cardiovascular disease. However, few prospective studies have investigated the associations between exposure to multiple metals and incident coronary heart disease (CHD).
We conducted a nested case-control study in the prospective Dongfeng-Tongji cohort, to investigate the prospective association between plasma metal concentrations and incident CHD.
A total of 1,621 incident CHD cases and 1,621 controls free of major cardiovascular disease at baseline and follow-up visits were matched on age (±5 years) and sex. We measured baseline fasting plasma concentrations of 23 metals and used conditional logistic regression models to estimate odds ratios (ORs) of CHD for metal concentrations categorized according to quartiles in controls.
Five metals (titanium, arsenic, selenium, aluminum, and barium) were significantly associated with CHD based on trend tests from single-metal multivariable models adjusted for established cardiovascular risk factors. When all five were included in the same model, adjusted ORs for barium and aluminum were close to the null, whereas associations with titanium, arsenic, and selenium were similar to estimates from single-metal models, and ORs comparing extreme quartiles were 1.32 (95% CI: 1.03, 1.69;
-trend=0.04), 1.78 (95% CI: 1.29, 2.46;
-trend=0.001), and 0.67 (95% CI: 0.52, 0.85;
-trend=0.001), respectively.
Our study suggested that incident CHD was positively associated with plasma levels of titanium and arsenic, and inversely associated with selenium. Additional research is needed to confirm these findings in other populations. https://doi.org/10.1289/EHP1521. |
| doi_str_mv | 10.1289/EHP1521 |
| format | Article |
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We conducted a nested case-control study in the prospective Dongfeng-Tongji cohort, to investigate the prospective association between plasma metal concentrations and incident CHD.
A total of 1,621 incident CHD cases and 1,621 controls free of major cardiovascular disease at baseline and follow-up visits were matched on age (±5 years) and sex. We measured baseline fasting plasma concentrations of 23 metals and used conditional logistic regression models to estimate odds ratios (ORs) of CHD for metal concentrations categorized according to quartiles in controls.
Five metals (titanium, arsenic, selenium, aluminum, and barium) were significantly associated with CHD based on trend tests from single-metal multivariable models adjusted for established cardiovascular risk factors. When all five were included in the same model, adjusted ORs for barium and aluminum were close to the null, whereas associations with titanium, arsenic, and selenium were similar to estimates from single-metal models, and ORs comparing extreme quartiles were 1.32 (95% CI: 1.03, 1.69;
-trend=0.04), 1.78 (95% CI: 1.29, 2.46;
-trend=0.001), and 0.67 (95% CI: 0.52, 0.85;
-trend=0.001), respectively.
Our study suggested that incident CHD was positively associated with plasma levels of titanium and arsenic, and inversely associated with selenium. Additional research is needed to confirm these findings in other populations. https://doi.org/10.1289/EHP1521.</description><identifier>ISSN: 0091-6765</identifier><identifier>EISSN: 1552-9924</identifier><identifier>DOI: 10.1289/EHP1521</identifier><identifier>PMID: 29064788</identifier><language>eng</language><publisher>United States: National Institute of Environmental Health Sciences</publisher><subject>Adult ; Adults ; Aged ; Aluminum ; Angina pectoris ; Angioplasty ; Arsenic ; Barium ; Biomarkers ; Cancer ; Cardiovascular disease ; Cardiovascular diseases ; Case-Control Studies ; China - epidemiology ; Coronary artery disease ; Coronary Disease - epidemiology ; Coronary heart disease ; Coronary vessels ; Diabetes ; Disease control ; Drinking water ; Electrocardiography ; Environmental Exposure - statistics & numerical data ; Environmental Pollutants - blood ; Environmental research ; Environmental toxicology ; Enzymes ; Female ; Health aspects ; Health risk assessment ; Health risks ; Heart ; Heart diseases ; Heavy metals ; Humans ; Ischemia ; Male ; Medical records ; Medical research ; Metal concentrations ; Metals ; Metals - blood ; Middle Aged ; Mortality ; Outdoor air quality ; Plasma ; Plasma levels ; Prospective Studies ; Quartiles ; Questionnaires ; Regression analysis ; Regression models ; Risk analysis ; Risk factors ; Selenium ; Studies ; Titanium ; Urine ; Veins & arteries</subject><ispartof>Environmental health perspectives, 2017-10, Vol.125 (10), p.107007</ispartof><rights>COPYRIGHT 2017 National Institute of Environmental Health Sciences</rights><rights>Copyright National Institute of Environmental Health Sciences Oct 2017</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c601t-8d2c791415e71a559c7ded34a7f517eba87a9c0521d2e997fa064f3646ee9b583</citedby><cites>FETCH-LOGICAL-c601t-8d2c791415e71a559c7ded34a7f517eba87a9c0521d2e997fa064f3646ee9b583</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5933370/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5933370/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,724,777,781,861,882,27905,27906,53772,53774</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/29064788$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Yuan, Yu</creatorcontrib><creatorcontrib>Xiao, Yang</creatorcontrib><creatorcontrib>Feng, Wei</creatorcontrib><creatorcontrib>Liu, Yiyi</creatorcontrib><creatorcontrib>Yu, Yanqiu</creatorcontrib><creatorcontrib>Zhou, Lue</creatorcontrib><creatorcontrib>Qiu, Gaokun</creatorcontrib><creatorcontrib>Wang, Hao</creatorcontrib><creatorcontrib>Liu, Bing</creatorcontrib><creatorcontrib>Liu, Kang</creatorcontrib><creatorcontrib>Yang, Handong</creatorcontrib><creatorcontrib>Li, Xiulou</creatorcontrib><creatorcontrib>Min, Xinwen</creatorcontrib><creatorcontrib>Zhang, Ce</creatorcontrib><creatorcontrib>Xu, Chengwei</creatorcontrib><creatorcontrib>Zhang, Xiaomin</creatorcontrib><creatorcontrib>He, Meian</creatorcontrib><creatorcontrib>Hu, Frank B</creatorcontrib><creatorcontrib>Pan, An</creatorcontrib><creatorcontrib>Wu, Tangchun</creatorcontrib><title>Plasma Metal Concentrations and Incident Coronary Heart Disease in Chinese Adults: The Dongfeng-Tongji Cohort</title><title>Environmental health perspectives</title><addtitle>Environ Health Perspect</addtitle><description>Circulating metals from both the natural environment and pollution have been linked to cardiovascular disease. However, few prospective studies have investigated the associations between exposure to multiple metals and incident coronary heart disease (CHD).
We conducted a nested case-control study in the prospective Dongfeng-Tongji cohort, to investigate the prospective association between plasma metal concentrations and incident CHD.
A total of 1,621 incident CHD cases and 1,621 controls free of major cardiovascular disease at baseline and follow-up visits were matched on age (±5 years) and sex. We measured baseline fasting plasma concentrations of 23 metals and used conditional logistic regression models to estimate odds ratios (ORs) of CHD for metal concentrations categorized according to quartiles in controls.
Five metals (titanium, arsenic, selenium, aluminum, and barium) were significantly associated with CHD based on trend tests from single-metal multivariable models adjusted for established cardiovascular risk factors. When all five were included in the same model, adjusted ORs for barium and aluminum were close to the null, whereas associations with titanium, arsenic, and selenium were similar to estimates from single-metal models, and ORs comparing extreme quartiles were 1.32 (95% CI: 1.03, 1.69;
-trend=0.04), 1.78 (95% CI: 1.29, 2.46;
-trend=0.001), and 0.67 (95% CI: 0.52, 0.85;
-trend=0.001), respectively.
Our study suggested that incident CHD was positively associated with plasma levels of titanium and arsenic, and inversely associated with selenium. Additional research is needed to confirm these findings in other populations. https://doi.org/10.1289/EHP1521.</description><subject>Adult</subject><subject>Adults</subject><subject>Aged</subject><subject>Aluminum</subject><subject>Angina pectoris</subject><subject>Angioplasty</subject><subject>Arsenic</subject><subject>Barium</subject><subject>Biomarkers</subject><subject>Cancer</subject><subject>Cardiovascular disease</subject><subject>Cardiovascular diseases</subject><subject>Case-Control Studies</subject><subject>China - epidemiology</subject><subject>Coronary artery disease</subject><subject>Coronary Disease - epidemiology</subject><subject>Coronary heart disease</subject><subject>Coronary vessels</subject><subject>Diabetes</subject><subject>Disease control</subject><subject>Drinking water</subject><subject>Electrocardiography</subject><subject>Environmental Exposure - statistics & numerical data</subject><subject>Environmental Pollutants - blood</subject><subject>Environmental research</subject><subject>Environmental toxicology</subject><subject>Enzymes</subject><subject>Female</subject><subject>Health aspects</subject><subject>Health risk assessment</subject><subject>Health risks</subject><subject>Heart</subject><subject>Heart diseases</subject><subject>Heavy metals</subject><subject>Humans</subject><subject>Ischemia</subject><subject>Male</subject><subject>Medical records</subject><subject>Medical research</subject><subject>Metal concentrations</subject><subject>Metals</subject><subject>Metals - blood</subject><subject>Middle Aged</subject><subject>Mortality</subject><subject>Outdoor air quality</subject><subject>Plasma</subject><subject>Plasma levels</subject><subject>Prospective Studies</subject><subject>Quartiles</subject><subject>Questionnaires</subject><subject>Regression analysis</subject><subject>Regression models</subject><subject>Risk analysis</subject><subject>Risk factors</subject><subject>Selenium</subject><subject>Studies</subject><subject>Titanium</subject><subject>Urine</subject><subject>Veins & 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Metal Concentrations and Incident Coronary Heart Disease in Chinese Adults: The Dongfeng-Tongji Cohort</title><author>Yuan, Yu ; Xiao, Yang ; Feng, Wei ; Liu, Yiyi ; Yu, Yanqiu ; Zhou, Lue ; Qiu, Gaokun ; Wang, Hao ; Liu, Bing ; Liu, Kang ; Yang, Handong ; Li, Xiulou ; Min, Xinwen ; Zhang, Ce ; Xu, Chengwei ; Zhang, Xiaomin ; He, Meian ; Hu, Frank B ; Pan, An ; Wu, Tangchun</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c601t-8d2c791415e71a559c7ded34a7f517eba87a9c0521d2e997fa064f3646ee9b583</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><topic>Adult</topic><topic>Adults</topic><topic>Aged</topic><topic>Aluminum</topic><topic>Angina pectoris</topic><topic>Angioplasty</topic><topic>Arsenic</topic><topic>Barium</topic><topic>Biomarkers</topic><topic>Cancer</topic><topic>Cardiovascular disease</topic><topic>Cardiovascular diseases</topic><topic>Case-Control 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Wei</au><au>Liu, Yiyi</au><au>Yu, Yanqiu</au><au>Zhou, Lue</au><au>Qiu, Gaokun</au><au>Wang, Hao</au><au>Liu, Bing</au><au>Liu, Kang</au><au>Yang, Handong</au><au>Li, Xiulou</au><au>Min, Xinwen</au><au>Zhang, Ce</au><au>Xu, Chengwei</au><au>Zhang, Xiaomin</au><au>He, Meian</au><au>Hu, Frank B</au><au>Pan, An</au><au>Wu, Tangchun</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Plasma Metal Concentrations and Incident Coronary Heart Disease in Chinese Adults: The Dongfeng-Tongji Cohort</atitle><jtitle>Environmental health perspectives</jtitle><addtitle>Environ Health Perspect</addtitle><date>2017-10-01</date><risdate>2017</risdate><volume>125</volume><issue>10</issue><spage>107007</spage><pages>107007-</pages><issn>0091-6765</issn><eissn>1552-9924</eissn><abstract>Circulating metals from both the natural environment and pollution have been linked to cardiovascular disease. However, few prospective studies have investigated the associations between exposure to multiple metals and incident coronary heart disease (CHD).
We conducted a nested case-control study in the prospective Dongfeng-Tongji cohort, to investigate the prospective association between plasma metal concentrations and incident CHD.
A total of 1,621 incident CHD cases and 1,621 controls free of major cardiovascular disease at baseline and follow-up visits were matched on age (±5 years) and sex. We measured baseline fasting plasma concentrations of 23 metals and used conditional logistic regression models to estimate odds ratios (ORs) of CHD for metal concentrations categorized according to quartiles in controls.
Five metals (titanium, arsenic, selenium, aluminum, and barium) were significantly associated with CHD based on trend tests from single-metal multivariable models adjusted for established cardiovascular risk factors. When all five were included in the same model, adjusted ORs for barium and aluminum were close to the null, whereas associations with titanium, arsenic, and selenium were similar to estimates from single-metal models, and ORs comparing extreme quartiles were 1.32 (95% CI: 1.03, 1.69;
-trend=0.04), 1.78 (95% CI: 1.29, 2.46;
-trend=0.001), and 0.67 (95% CI: 0.52, 0.85;
-trend=0.001), respectively.
Our study suggested that incident CHD was positively associated with plasma levels of titanium and arsenic, and inversely associated with selenium. Additional research is needed to confirm these findings in other populations. https://doi.org/10.1289/EHP1521.</abstract><cop>United States</cop><pub>National Institute of Environmental Health Sciences</pub><pmid>29064788</pmid><doi>10.1289/EHP1521</doi><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0091-6765 |
| ispartof | Environmental health perspectives, 2017-10, Vol.125 (10), p.107007 |
| issn | 0091-6765 1552-9924 |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_5933370 |
| source | MEDLINE; DOAJ Directory of Open Access Journals; PubMed Central Open Access; Jstor Complete Legacy; EZB-FREE-00999 freely available EZB journals; PubMed Central |
| subjects | Adult Adults Aged Aluminum Angina pectoris Angioplasty Arsenic Barium Biomarkers Cancer Cardiovascular disease Cardiovascular diseases Case-Control Studies China - epidemiology Coronary artery disease Coronary Disease - epidemiology Coronary heart disease Coronary vessels Diabetes Disease control Drinking water Electrocardiography Environmental Exposure - statistics & numerical data Environmental Pollutants - blood Environmental research Environmental toxicology Enzymes Female Health aspects Health risk assessment Health risks Heart Heart diseases Heavy metals Humans Ischemia Male Medical records Medical research Metal concentrations Metals Metals - blood Middle Aged Mortality Outdoor air quality Plasma Plasma levels Prospective Studies Quartiles Questionnaires Regression analysis Regression models Risk analysis Risk factors Selenium Studies Titanium Urine Veins & arteries |
| title | Plasma Metal Concentrations and Incident Coronary Heart Disease in Chinese Adults: The Dongfeng-Tongji Cohort |
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