Dendrimer-Entrapped Gold Nanoparticles as Potential CT Contrast Agents for Localizing Sentinel Lymph Node via Indirect CT Lymphography on Rabbit Model
Objective. To investigate the potential use of indirect computed tomography lymphography (CT-LG) with dendrimer-entrapped gold nanoparticles (Au DENPs) in the localization and enhanced imaging of cervical sentinel lymph node (SLN) on rabbit model. Methods. Twelve rabbits were randomly divided into t...
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| description | Objective. To investigate the potential use of indirect computed tomography lymphography (CT-LG) with dendrimer-entrapped gold nanoparticles (Au DENPs) in the localization and enhanced imaging of cervical sentinel lymph node (SLN) on rabbit model. Methods. Twelve rabbits were randomly divided into two groups: the positive control group and the experimental group. In the control group, indirect CT-LG was performed with the injection of 0.5 ml activated carbon nanoparticles (ACNP) and Omnipaque mixture suspension in the right tongue submucosa. CT images were acquired before the injection and 1, 5, 10, and 15 min after the injection, respectively. In the experimental group, indirect CT-LG injection with 0.5 ml Au DENPs suspension was performed in the right tongue submucosa. CT images were obtained before the injection and 1, 5, 10, and 15 min and 1, 2, 6, 24, 48, and 72 h after the injection, respectively. Then, SLN identification and enhancement characteristics were evaluated. Results. Indirect CT-LG revealed the enhancement of one right deep cervical lymph nodes in all animals, which was SLN. SLN location was marked with black color (ACNP dye) or purple-black color (Au DENPs dye). At each detection time point, the enhanced SLN attenuation values of control rabbits were statistically significantly higher than that of the plain scan, respectively ( P < 0.05 ). Also the values of experimental rabbits were statistically significantly higher than that of the control at the same time point after injection ( P < 0.05 ). The detection rate of SLN was 100%. Conclusions. Indirect CT-LG with injection of Au DENPs as CT contrast agents can locate the SLN for a long period of time and enrich the SLN black dye. It is helpful for SLNs identification during the operation. |
| doi_str_mv | 10.1155/2018/1230151 |
| format | Article |
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To investigate the potential use of indirect computed tomography lymphography (CT-LG) with dendrimer-entrapped gold nanoparticles (Au DENPs) in the localization and enhanced imaging of cervical sentinel lymph node (SLN) on rabbit model. Methods. Twelve rabbits were randomly divided into two groups: the positive control group and the experimental group. In the control group, indirect CT-LG was performed with the injection of 0.5 ml activated carbon nanoparticles (ACNP) and Omnipaque mixture suspension in the right tongue submucosa. CT images were acquired before the injection and 1, 5, 10, and 15 min after the injection, respectively. In the experimental group, indirect CT-LG injection with 0.5 ml Au DENPs suspension was performed in the right tongue submucosa. CT images were obtained before the injection and 1, 5, 10, and 15 min and 1, 2, 6, 24, 48, and 72 h after the injection, respectively. Then, SLN identification and enhancement characteristics were evaluated. Results. Indirect CT-LG revealed the enhancement of one right deep cervical lymph nodes in all animals, which was SLN. SLN location was marked with black color (ACNP dye) or purple-black color (Au DENPs dye). At each detection time point, the enhanced SLN attenuation values of control rabbits were statistically significantly higher than that of the plain scan, respectively ( P < 0.05 ). Also the values of experimental rabbits were statistically significantly higher than that of the control at the same time point after injection ( P < 0.05 ). The detection rate of SLN was 100%. Conclusions. Indirect CT-LG with injection of Au DENPs as CT contrast agents can locate the SLN for a long period of time and enrich the SLN black dye. It is helpful for SLNs identification during the operation.</description><identifier>ISSN: 2314-6133</identifier><identifier>EISSN: 2314-6141</identifier><identifier>DOI: 10.1155/2018/1230151</identifier><identifier>PMID: 29850482</identifier><language>eng</language><publisher>Cairo, Egypt: Hindawi Publishing Corporation</publisher><subject>Activated carbon ; Animals ; Biomedical materials ; Biopsy ; Cancer ; Color ; Computed tomography ; Contrast agents ; Contrast Media - chemistry ; CT imaging ; Dendrimers - chemistry ; Diagnosis, Radioscopic ; Dyes ; Entrapment (Criminal law) ; Gold ; Gold - chemistry ; Image acquisition ; Injection ; Localization ; Lymph nodes ; Lymphatic system ; Lymphography ; Medical imaging ; Metal Nanoparticles - chemistry ; Metastasis ; Models, Animal ; Nanoparticles ; Neck ; NMR ; Nuclear magnetic resonance ; Otology ; Rabbits ; Sentinel Lymph Node - diagnostic imaging ; Thoracic surgery ; Tomography, X-Ray Computed ; Tongue ; Ultrasonic imaging</subject><ispartof>BioMed research international, 2018-01, Vol.2018 (2018), p.1-6</ispartof><rights>Copyright © 2018 Fang Shi et al.</rights><rights>COPYRIGHT 2018 John Wiley & Sons, Inc.</rights><rights>Copyright © 2018 Fang Shi et al.; This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.</rights><rights>Copyright © 2018 Fang Shi et al. 2018</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c499t-148c85b4a40725cabef425cb9d76a6f67bcb80cbd58280934c28ade3e5b5bc913</citedby><cites>FETCH-LOGICAL-c499t-148c85b4a40725cabef425cb9d76a6f67bcb80cbd58280934c28ade3e5b5bc913</cites><orcidid>0000-0002-7617-2832 ; 0000-0001-5668-5107 ; 0000-0002-0578-9675</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5932527/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5932527/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,881,27901,27902,53766,53768</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/29850482$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><contributor>Ren, Jinsong</contributor><creatorcontrib>Shu, Yilai</creatorcontrib><creatorcontrib>Sha, Yan</creatorcontrib><creatorcontrib>Chen, Jian</creatorcontrib><creatorcontrib>Yang, Yue</creatorcontrib><creatorcontrib>Shi, Fang</creatorcontrib><creatorcontrib>Wu, Haitao</creatorcontrib><title>Dendrimer-Entrapped Gold Nanoparticles as Potential CT Contrast Agents for Localizing Sentinel Lymph Node via Indirect CT Lymphography on Rabbit Model</title><title>BioMed research international</title><addtitle>Biomed Res Int</addtitle><description>Objective. To investigate the potential use of indirect computed tomography lymphography (CT-LG) with dendrimer-entrapped gold nanoparticles (Au DENPs) in the localization and enhanced imaging of cervical sentinel lymph node (SLN) on rabbit model. Methods. Twelve rabbits were randomly divided into two groups: the positive control group and the experimental group. In the control group, indirect CT-LG was performed with the injection of 0.5 ml activated carbon nanoparticles (ACNP) and Omnipaque mixture suspension in the right tongue submucosa. CT images were acquired before the injection and 1, 5, 10, and 15 min after the injection, respectively. In the experimental group, indirect CT-LG injection with 0.5 ml Au DENPs suspension was performed in the right tongue submucosa. CT images were obtained before the injection and 1, 5, 10, and 15 min and 1, 2, 6, 24, 48, and 72 h after the injection, respectively. Then, SLN identification and enhancement characteristics were evaluated. Results. Indirect CT-LG revealed the enhancement of one right deep cervical lymph nodes in all animals, which was SLN. SLN location was marked with black color (ACNP dye) or purple-black color (Au DENPs dye). At each detection time point, the enhanced SLN attenuation values of control rabbits were statistically significantly higher than that of the plain scan, respectively ( P < 0.05 ). Also the values of experimental rabbits were statistically significantly higher than that of the control at the same time point after injection ( P < 0.05 ). The detection rate of SLN was 100%. Conclusions. Indirect CT-LG with injection of Au DENPs as CT contrast agents can locate the SLN for a long period of time and enrich the SLN black dye. It is helpful for SLNs identification during the operation.</description><subject>Activated carbon</subject><subject>Animals</subject><subject>Biomedical materials</subject><subject>Biopsy</subject><subject>Cancer</subject><subject>Color</subject><subject>Computed tomography</subject><subject>Contrast agents</subject><subject>Contrast Media - chemistry</subject><subject>CT imaging</subject><subject>Dendrimers - chemistry</subject><subject>Diagnosis, Radioscopic</subject><subject>Dyes</subject><subject>Entrapment (Criminal law)</subject><subject>Gold</subject><subject>Gold - chemistry</subject><subject>Image acquisition</subject><subject>Injection</subject><subject>Localization</subject><subject>Lymph nodes</subject><subject>Lymphatic system</subject><subject>Lymphography</subject><subject>Medical imaging</subject><subject>Metal Nanoparticles - chemistry</subject><subject>Metastasis</subject><subject>Models, Animal</subject><subject>Nanoparticles</subject><subject>Neck</subject><subject>NMR</subject><subject>Nuclear magnetic resonance</subject><subject>Otology</subject><subject>Rabbits</subject><subject>Sentinel Lymph Node - diagnostic imaging</subject><subject>Thoracic surgery</subject><subject>Tomography, X-Ray Computed</subject><subject>Tongue</subject><subject>Ultrasonic imaging</subject><issn>2314-6133</issn><issn>2314-6141</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><sourceid>RHX</sourceid><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNqNkUtvEzEURkcIRKvSHWtkiSWE-jljb5CiUEqlUBCUteXXTFxN7Kk9KUp_SH8vHhJC2eHNtXyPjq_9VdVLBN8hxNgZhoifIUwgYuhJdYwJorMaUfT0sCfkqDrN-QaWxVENRf28OsKCM0g5Pq4ePrhgk1-7NDsPY1LD4Cy4iL0FVyrEQaXRm95loDL4GkcXRq96sLgGizjReQTzrhxm0MYEltGo3t_70IHvExlcD5bb9bACV9E6cOcVuAzWJ2fGSfG7Fbty52oLYgDflNZ-BJ8L27-onrWqz-50X0-qHx_PrxefZssvF5eL-XJmqBDjDFFuONNUUdhgZpR2LS1VC9vUqm7rRhvNodGWccyhINRgrqwjjmmmjUDkpHq_8w4bvXbWuOlVvRzKj6i0lVF5-W8n-JXs4p1kgmCGmyJ4vRekeLtxeZQ3cZNCmVliSDARrIGPqE71TvrQxiIza5-NnNcYcQiRwIV6u6NMijkn1x7mQFBOccspbrmPu-CvHs9-gP-EW4A3O2Dlg1U__X_qXGFcq_7SCFPUYPIL_169KQ</recordid><startdate>20180101</startdate><enddate>20180101</enddate><creator>Shu, Yilai</creator><creator>Sha, Yan</creator><creator>Chen, Jian</creator><creator>Yang, Yue</creator><creator>Shi, Fang</creator><creator>Wu, Haitao</creator><general>Hindawi Publishing Corporation</general><general>Hindawi</general><general>John Wiley & Sons, Inc</general><general>Hindawi Limited</general><scope>ADJCN</scope><scope>AHFXO</scope><scope>RHU</scope><scope>RHW</scope><scope>RHX</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QL</scope><scope>7QO</scope><scope>7T7</scope><scope>7TK</scope><scope>7U7</scope><scope>7U9</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8FD</scope><scope>8FE</scope><scope>8FG</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>ARAPS</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>CWDGH</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M7N</scope><scope>M7P</scope><scope>P5Z</scope><scope>P62</scope><scope>P64</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0002-7617-2832</orcidid><orcidid>https://orcid.org/0000-0001-5668-5107</orcidid><orcidid>https://orcid.org/0000-0002-0578-9675</orcidid></search><sort><creationdate>20180101</creationdate><title>Dendrimer-Entrapped Gold Nanoparticles as Potential CT Contrast Agents for Localizing Sentinel Lymph Node via Indirect CT Lymphography on Rabbit Model</title><author>Shu, Yilai ; Sha, Yan ; Chen, Jian ; Yang, Yue ; Shi, Fang ; Wu, Haitao</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c499t-148c85b4a40725cabef425cb9d76a6f67bcb80cbd58280934c28ade3e5b5bc913</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2018</creationdate><topic>Activated carbon</topic><topic>Animals</topic><topic>Biomedical materials</topic><topic>Biopsy</topic><topic>Cancer</topic><topic>Color</topic><topic>Computed tomography</topic><topic>Contrast agents</topic><topic>Contrast Media - chemistry</topic><topic>CT imaging</topic><topic>Dendrimers - chemistry</topic><topic>Diagnosis, Radioscopic</topic><topic>Dyes</topic><topic>Entrapment (Criminal law)</topic><topic>Gold</topic><topic>Gold - chemistry</topic><topic>Image acquisition</topic><topic>Injection</topic><topic>Localization</topic><topic>Lymph nodes</topic><topic>Lymphatic system</topic><topic>Lymphography</topic><topic>Medical imaging</topic><topic>Metal Nanoparticles - chemistry</topic><topic>Metastasis</topic><topic>Models, Animal</topic><topic>Nanoparticles</topic><topic>Neck</topic><topic>NMR</topic><topic>Nuclear magnetic resonance</topic><topic>Otology</topic><topic>Rabbits</topic><topic>Sentinel Lymph Node - diagnostic imaging</topic><topic>Thoracic surgery</topic><topic>Tomography, X-Ray Computed</topic><topic>Tongue</topic><topic>Ultrasonic imaging</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Shu, Yilai</creatorcontrib><creatorcontrib>Sha, Yan</creatorcontrib><creatorcontrib>Chen, Jian</creatorcontrib><creatorcontrib>Yang, Yue</creatorcontrib><creatorcontrib>Shi, Fang</creatorcontrib><creatorcontrib>Wu, Haitao</creatorcontrib><collection>الدوريات العلمية والإحصائية - e-Marefa Academic and Statistical Periodicals</collection><collection>معرفة - المحتوى العربي الأكاديمي المتكامل - e-Marefa Academic Complete</collection><collection>Hindawi Publishing Complete</collection><collection>Hindawi Publishing Subscription Journals</collection><collection>Hindawi Publishing Open Access</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Biotechnology Research Abstracts</collection><collection>Industrial and Applied Microbiology Abstracts (Microbiology A)</collection><collection>Neurosciences Abstracts</collection><collection>Toxicology Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Technology Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>Advanced Technologies & Aerospace Collection</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Technology Collection (ProQuest)</collection><collection>Natural Science Collection (ProQuest)</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>Middle East & Africa Database</collection><collection>ProQuest Central Korea</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Biological Science Database</collection><collection>Advanced Technologies & Aerospace Database</collection><collection>ProQuest Advanced Technologies & Aerospace Collection</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>BioMed research international</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Shu, Yilai</au><au>Sha, Yan</au><au>Chen, Jian</au><au>Yang, Yue</au><au>Shi, Fang</au><au>Wu, Haitao</au><au>Ren, Jinsong</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Dendrimer-Entrapped Gold Nanoparticles as Potential CT Contrast Agents for Localizing Sentinel Lymph Node via Indirect CT Lymphography on Rabbit Model</atitle><jtitle>BioMed research international</jtitle><addtitle>Biomed Res Int</addtitle><date>2018-01-01</date><risdate>2018</risdate><volume>2018</volume><issue>2018</issue><spage>1</spage><epage>6</epage><pages>1-6</pages><issn>2314-6133</issn><eissn>2314-6141</eissn><abstract>Objective. To investigate the potential use of indirect computed tomography lymphography (CT-LG) with dendrimer-entrapped gold nanoparticles (Au DENPs) in the localization and enhanced imaging of cervical sentinel lymph node (SLN) on rabbit model. Methods. Twelve rabbits were randomly divided into two groups: the positive control group and the experimental group. In the control group, indirect CT-LG was performed with the injection of 0.5 ml activated carbon nanoparticles (ACNP) and Omnipaque mixture suspension in the right tongue submucosa. CT images were acquired before the injection and 1, 5, 10, and 15 min after the injection, respectively. In the experimental group, indirect CT-LG injection with 0.5 ml Au DENPs suspension was performed in the right tongue submucosa. CT images were obtained before the injection and 1, 5, 10, and 15 min and 1, 2, 6, 24, 48, and 72 h after the injection, respectively. Then, SLN identification and enhancement characteristics were evaluated. Results. Indirect CT-LG revealed the enhancement of one right deep cervical lymph nodes in all animals, which was SLN. SLN location was marked with black color (ACNP dye) or purple-black color (Au DENPs dye). At each detection time point, the enhanced SLN attenuation values of control rabbits were statistically significantly higher than that of the plain scan, respectively ( P < 0.05 ). Also the values of experimental rabbits were statistically significantly higher than that of the control at the same time point after injection ( P < 0.05 ). The detection rate of SLN was 100%. Conclusions. Indirect CT-LG with injection of Au DENPs as CT contrast agents can locate the SLN for a long period of time and enrich the SLN black dye. It is helpful for SLNs identification during the operation.</abstract><cop>Cairo, Egypt</cop><pub>Hindawi Publishing Corporation</pub><pmid>29850482</pmid><doi>10.1155/2018/1230151</doi><tpages>6</tpages><orcidid>https://orcid.org/0000-0002-7617-2832</orcidid><orcidid>https://orcid.org/0000-0001-5668-5107</orcidid><orcidid>https://orcid.org/0000-0002-0578-9675</orcidid><oa>free_for_read</oa></addata></record> |
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| subjects | Activated carbon Animals Biomedical materials Biopsy Cancer Color Computed tomography Contrast agents Contrast Media - chemistry CT imaging Dendrimers - chemistry Diagnosis, Radioscopic Dyes Entrapment (Criminal law) Gold Gold - chemistry Image acquisition Injection Localization Lymph nodes Lymphatic system Lymphography Medical imaging Metal Nanoparticles - chemistry Metastasis Models, Animal Nanoparticles Neck NMR Nuclear magnetic resonance Otology Rabbits Sentinel Lymph Node - diagnostic imaging Thoracic surgery Tomography, X-Ray Computed Tongue Ultrasonic imaging |
| title | Dendrimer-Entrapped Gold Nanoparticles as Potential CT Contrast Agents for Localizing Sentinel Lymph Node via Indirect CT Lymphography on Rabbit Model |
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