Directly Reprogrammed Human Neurons Retain Aging-Associated Transcriptomic Signatures and Reveal Age-Related Nucleocytoplasmic Defects

Aging is a major risk factor for many human diseases, and in vitro generation of human neurons is an attractive approach for modeling aging-related brain disorders. However, modeling aging in differentiated human neurons has proved challenging. We generated neurons from human donors across a broad r...

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Veröffentlicht in:	Cell stem cell 2015-12, Vol.17 (6), p.705-718
Hauptverfasser:	Mertens, Jerome, Paquola, Apuã C.M., Ku, Manching, Hatch, Emily, Böhnke, Lena, Ladjevardi, Shauheen, McGrath, Sean, Campbell, Benjamin, Lee, Hyungjun, Herdy, Joseph R., Gonçalves, J. Tiago, Toda, Tomohisa, Kim, Yongsung, Winkler, Jürgen, Yao, Jun, Hetzer, Martin W., Gage, Fred H.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adolescent Adult Aged Aged, 80 and over Aging Cell Nucleus - metabolism Cell Separation Cellular Reprogramming Child Child, Preschool Cytoplasm - metabolism Fibroblasts - cytology Flow Cytometry Humans Induced Pluripotent Stem Cells - cytology Infant Infant, Newborn Middle Aged Neural Cell Adhesion Molecules - metabolism Neurons - cytology ran GTP-Binding Protein - metabolism Transcriptome Young Adult
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