Protein-Specific Features Associated with Variability in Human Antibody Responses to Plasmodium falciparum Malaria Antigens
The magnitude of antibody responses varies across the individual proteins that constitute any given microorganism, both in the context of natural infection and vaccination with attenuated or inactivated pathogens. The protein-specific factors underlying this variability are poorly understood. In 267...
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| Veröffentlicht in: | The American journal of tropical medicine and hygiene 2018-01, Vol.98 (1), p.57-66 |
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| container_title | The American journal of tropical medicine and hygiene |
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| creator | Liu, Eugene W Skinner, Jeff Tran, Tuan M Kumar, Krishan Narum, David L Jain, Aarti Ongoiba, Aissata Traoré, Boubacar Felgner, Philip L Crompton, Peter D |
| description | The magnitude of antibody responses varies across the individual proteins that constitute any given microorganism, both in the context of natural infection and vaccination with attenuated or inactivated pathogens. The protein-specific factors underlying this variability are poorly understood. In 267 individuals exposed to intense seasonal malaria, we examined the relationship between immunoglobulin G (IgG) responses to 861
proteins and specific features of these proteins, including their subcellular location, relative abundance, degree of polymorphism, and whether they are predicted to have human orthologs. We found that IgG reactivity was significantly higher to extracellular and plasma membrane proteins and also correlated positively with both protein abundance and degree of protein polymorphism. Conversely, IgG reactivity was significantly lower to proteins predicted to have human orthologs. These findings provide insight into protein-specific factors that are associated with variability in the magnitude of antibody responses to natural
infection-data that could inform vaccine strategies to optimize antibody-mediated immunity as well as the selection of antigens for sero-diagnostic purposes. |
| doi_str_mv | 10.4269/ajtmh.17-0437 |
| format | Article |
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proteins and specific features of these proteins, including their subcellular location, relative abundance, degree of polymorphism, and whether they are predicted to have human orthologs. We found that IgG reactivity was significantly higher to extracellular and plasma membrane proteins and also correlated positively with both protein abundance and degree of protein polymorphism. Conversely, IgG reactivity was significantly lower to proteins predicted to have human orthologs. These findings provide insight into protein-specific factors that are associated with variability in the magnitude of antibody responses to natural
infection-data that could inform vaccine strategies to optimize antibody-mediated immunity as well as the selection of antigens for sero-diagnostic purposes.</description><identifier>ISSN: 0002-9637</identifier><identifier>EISSN: 1476-1645</identifier><identifier>DOI: 10.4269/ajtmh.17-0437</identifier><identifier>PMID: 29141757</identifier><language>eng</language><publisher>United States: Institute of Tropical Medicine</publisher><subject>Adolescent ; Adult ; Age Factors ; Antibodies, Protozoan - immunology ; Antibody Formation - immunology ; Antigens ; Antigens, Protozoan - immunology ; Child ; Child, Preschool ; Cross Reactions - immunology ; Erythrocytes ; Female ; Humans ; Immunoglobulin G - immunology ; Infant ; Malaria ; Malaria, Falciparum - epidemiology ; Malaria, Falciparum - immunology ; Male ; Mali - epidemiology ; Merozoites - immunology ; Plasmodium falciparum - immunology ; Protein Array Analysis ; Proteins ; Protozoan Proteins - immunology ; Young Adult</subject><ispartof>The American journal of tropical medicine and hygiene, 2018-01, Vol.98 (1), p.57-66</ispartof><rights>Copyright Institute of Tropical Medicine 2018</rights><rights>The American Society of Tropical Medicine and Hygiene 2018</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c415t-b4a516b178404b49f52107ebbe9f81a5ae988a2536442f1f83bb8d2d0bfa8c73</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5928716/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5928716/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,885,27924,27925,53791,53793</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/29141757$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Liu, Eugene W</creatorcontrib><creatorcontrib>Skinner, Jeff</creatorcontrib><creatorcontrib>Tran, Tuan M</creatorcontrib><creatorcontrib>Kumar, Krishan</creatorcontrib><creatorcontrib>Narum, David L</creatorcontrib><creatorcontrib>Jain, Aarti</creatorcontrib><creatorcontrib>Ongoiba, Aissata</creatorcontrib><creatorcontrib>Traoré, Boubacar</creatorcontrib><creatorcontrib>Felgner, Philip L</creatorcontrib><creatorcontrib>Crompton, Peter D</creatorcontrib><title>Protein-Specific Features Associated with Variability in Human Antibody Responses to Plasmodium falciparum Malaria Antigens</title><title>The American journal of tropical medicine and hygiene</title><addtitle>Am J Trop Med Hyg</addtitle><description>The magnitude of antibody responses varies across the individual proteins that constitute any given microorganism, both in the context of natural infection and vaccination with attenuated or inactivated pathogens. The protein-specific factors underlying this variability are poorly understood. In 267 individuals exposed to intense seasonal malaria, we examined the relationship between immunoglobulin G (IgG) responses to 861
proteins and specific features of these proteins, including their subcellular location, relative abundance, degree of polymorphism, and whether they are predicted to have human orthologs. We found that IgG reactivity was significantly higher to extracellular and plasma membrane proteins and also correlated positively with both protein abundance and degree of protein polymorphism. Conversely, IgG reactivity was significantly lower to proteins predicted to have human orthologs. These findings provide insight into protein-specific factors that are associated with variability in the magnitude of antibody responses to natural
infection-data that could inform vaccine strategies to optimize antibody-mediated immunity as well as the selection of antigens for sero-diagnostic purposes.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Age Factors</subject><subject>Antibodies, Protozoan - immunology</subject><subject>Antibody Formation - immunology</subject><subject>Antigens</subject><subject>Antigens, Protozoan - immunology</subject><subject>Child</subject><subject>Child, Preschool</subject><subject>Cross Reactions - immunology</subject><subject>Erythrocytes</subject><subject>Female</subject><subject>Humans</subject><subject>Immunoglobulin G - immunology</subject><subject>Infant</subject><subject>Malaria</subject><subject>Malaria, Falciparum - epidemiology</subject><subject>Malaria, Falciparum - immunology</subject><subject>Male</subject><subject>Mali - epidemiology</subject><subject>Merozoites - immunology</subject><subject>Plasmodium falciparum - immunology</subject><subject>Protein Array Analysis</subject><subject>Proteins</subject><subject>Protozoan Proteins - immunology</subject><subject>Young Adult</subject><issn>0002-9637</issn><issn>1476-1645</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpdkUFv1DAQhS1ERZfCkSuyxIVLWo9jx8kFaVVRilTUCiqu1jhxul4ldrAd0Kp_vtm2VNDTjDTfPM2bR8g7YMeCV80JbvO4OQZVMFGqF2QFQlUFVEK-JCvGGC-aqlSH5HVKW8ag5gCvyCFvQICSakVur2LI1vnix2Rb17uWnlnMc7SJrlMKrcNsO_rH5Q39idGhcYPLO-o8PZ9H9HTtszOh29HvNk3Bp2UvB3o1YBpD5-aR9ji0bsK4tN9w2Evc79xYn96Qg2Wa7NvHekSuzz5fn54XF5dfvp6uL4pWgMyFESihMqBqwYQRTS85MGWNsU1fA0q0TV0jl2UlBO-hr0tj6o53zPRYt6o8Ip8eZKfZjLZrrc8RBz1FN2Lc6YBO_z_xbqNvwm8tG14rqBaBj48CMfyabcp6dKm1w4DehjlpaCrJpWJSLOiHZ-g2zNEv7vTy-YrJBkAuVPFAtTGkFG3_dAwwvU9V36eqQel9qgv__l8HT_TfGMs7Qa-hUA</recordid><startdate>20180101</startdate><enddate>20180101</enddate><creator>Liu, Eugene W</creator><creator>Skinner, Jeff</creator><creator>Tran, Tuan M</creator><creator>Kumar, Krishan</creator><creator>Narum, David L</creator><creator>Jain, Aarti</creator><creator>Ongoiba, Aissata</creator><creator>Traoré, Boubacar</creator><creator>Felgner, Philip L</creator><creator>Crompton, Peter D</creator><general>Institute of Tropical Medicine</general><general>The American Society of Tropical Medicine and Hygiene</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20180101</creationdate><title>Protein-Specific Features Associated with Variability in Human Antibody Responses to Plasmodium falciparum Malaria Antigens</title><author>Liu, Eugene W ; Skinner, Jeff ; Tran, Tuan M ; Kumar, Krishan ; Narum, David L ; Jain, Aarti ; Ongoiba, Aissata ; Traoré, Boubacar ; Felgner, Philip L ; Crompton, Peter D</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c415t-b4a516b178404b49f52107ebbe9f81a5ae988a2536442f1f83bb8d2d0bfa8c73</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2018</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Age Factors</topic><topic>Antibodies, Protozoan - immunology</topic><topic>Antibody Formation - immunology</topic><topic>Antigens</topic><topic>Antigens, Protozoan - immunology</topic><topic>Child</topic><topic>Child, Preschool</topic><topic>Cross Reactions - immunology</topic><topic>Erythrocytes</topic><topic>Female</topic><topic>Humans</topic><topic>Immunoglobulin G - immunology</topic><topic>Infant</topic><topic>Malaria</topic><topic>Malaria, Falciparum - epidemiology</topic><topic>Malaria, Falciparum - immunology</topic><topic>Male</topic><topic>Mali - epidemiology</topic><topic>Merozoites - immunology</topic><topic>Plasmodium falciparum - immunology</topic><topic>Protein Array Analysis</topic><topic>Proteins</topic><topic>Protozoan Proteins - immunology</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Liu, Eugene W</creatorcontrib><creatorcontrib>Skinner, Jeff</creatorcontrib><creatorcontrib>Tran, Tuan M</creatorcontrib><creatorcontrib>Kumar, Krishan</creatorcontrib><creatorcontrib>Narum, David L</creatorcontrib><creatorcontrib>Jain, Aarti</creatorcontrib><creatorcontrib>Ongoiba, Aissata</creatorcontrib><creatorcontrib>Traoré, Boubacar</creatorcontrib><creatorcontrib>Felgner, Philip L</creatorcontrib><creatorcontrib>Crompton, Peter D</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>The American journal of tropical medicine and hygiene</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Liu, Eugene W</au><au>Skinner, Jeff</au><au>Tran, Tuan M</au><au>Kumar, Krishan</au><au>Narum, David L</au><au>Jain, Aarti</au><au>Ongoiba, Aissata</au><au>Traoré, Boubacar</au><au>Felgner, Philip L</au><au>Crompton, Peter D</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Protein-Specific Features Associated with Variability in Human Antibody Responses to Plasmodium falciparum Malaria Antigens</atitle><jtitle>The American journal of tropical medicine and hygiene</jtitle><addtitle>Am J Trop Med Hyg</addtitle><date>2018-01-01</date><risdate>2018</risdate><volume>98</volume><issue>1</issue><spage>57</spage><epage>66</epage><pages>57-66</pages><issn>0002-9637</issn><eissn>1476-1645</eissn><abstract>The magnitude of antibody responses varies across the individual proteins that constitute any given microorganism, both in the context of natural infection and vaccination with attenuated or inactivated pathogens. The protein-specific factors underlying this variability are poorly understood. In 267 individuals exposed to intense seasonal malaria, we examined the relationship between immunoglobulin G (IgG) responses to 861
proteins and specific features of these proteins, including their subcellular location, relative abundance, degree of polymorphism, and whether they are predicted to have human orthologs. We found that IgG reactivity was significantly higher to extracellular and plasma membrane proteins and also correlated positively with both protein abundance and degree of protein polymorphism. Conversely, IgG reactivity was significantly lower to proteins predicted to have human orthologs. These findings provide insight into protein-specific factors that are associated with variability in the magnitude of antibody responses to natural
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| subjects | Adolescent Adult Age Factors Antibodies, Protozoan - immunology Antibody Formation - immunology Antigens Antigens, Protozoan - immunology Child Child, Preschool Cross Reactions - immunology Erythrocytes Female Humans Immunoglobulin G - immunology Infant Malaria Malaria, Falciparum - epidemiology Malaria, Falciparum - immunology Male Mali - epidemiology Merozoites - immunology Plasmodium falciparum - immunology Protein Array Analysis Proteins Protozoan Proteins - immunology Young Adult |
| title | Protein-Specific Features Associated with Variability in Human Antibody Responses to Plasmodium falciparum Malaria Antigens |
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