miR‑3147 serves as an oncomiR in vulvar squamous cell cancer via Smad4 suppression

The incidence of vulvar squamous cell carcinoma (VSCC) has increased annually over the last decade. MicroRNAs (miRNAs/miRs) serve an important role in tumor progression and development. Our previous microarray studies have revealed that miR‑3147 was overexpressed in VSCC. However, its function and u...

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Veröffentlicht in:	Molecular medicine reports 2018-05, Vol.17 (5), p.6397-6404
Hauptverfasser:	Yang, Xiu-Hua, Guo, Feng
Format:	Artikel
Sprache:	eng
Schlagworte:	Binding sites Bone morphogenetic proteins Cancer therapies Cell cycle Cell growth Cell migration Cell proliferation DNA microarrays Gene expression Genetic aspects Genital cancers Gynecology Human papillomavirus Lymphoma Medical prognosis Mesenchyme Metastasis MicroRNAs miRNA Obstetrics Polymerase chain reaction Proteins Reverse transcription Risk factors Signal transduction siRNA Smad protein Smad4 protein Squamous cell carcinoma Therapeutic applications Transforming growth factor Transforming growth factor-b Tumors
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