Plasmepsins IX and X are essential and druggable mediators of malaria parasite egress and invasion

Proteases of the malaria parasite Plasmodium falciparum have long been investigated as drug targets. The P. falciparum genome encodes 10 aspartic proteases called plasmepsins, which are involved in diverse cellular processes. Most have been studied extensively but the functions of plasmepsins IX and...

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Veröffentlicht in:	Science (American Association for the Advancement of Science) 2017-10, Vol.358 (6362), p.518-522
Hauptverfasser:	Nasamu, Armiyaw S., Glushakova, Svetlana, Russo, Ilaria, Vaupel, Barbara, Oksman, Anna, Kim, Arthur S., Fremont, Daved H., Tolia, Niraj, Beck, Josh R., Meyers, Marvin J., Niles, Jacquin C., Zimmerberg, Joshua, Goldberg, Daniel E.
Format:	Artikel
Sprache:	eng
Schlagworte:	Administration, Oral Animals Antimalarial activity Antimalarial agents Antimalarials - administration & dosage Antimalarials - chemistry Antimalarials - pharmacology Antimalarials - therapeutic use Aspartic Acid Endopeptidases - antagonists & inhibitors Blood Blood circulation Cell membranes Disease Models, Animal Egress Erythrocytes Erythrocytes - parasitology Fever Genomes Malaria Malaria, Falciparum - drug therapy Maturation Membranes Merozoites Mice Parasites Plasmodium falciparum Plasmodium falciparum - drug effects Plasmodium falciparum - enzymology Plasmodium falciparum - genetics Plasmodium falciparum - pathogenicity Protease Protease inhibitors Proteases Proteinase inhibitors Protozoan Proteins - metabolism Secretory vesicles Serine Serine proteinase Subtilisin Subtilisins - metabolism Vector-borne diseases
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