Prolonged survival of transplanted stem cells after ischaemic injury via the slow release of pro-survival peptides from a collagen matrix

Stem-cell-based therapies hold considerable promise for regenerative medicine. However, acute donor-cell death within several weeks after cell delivery remains a critical hurdle for clinical translation. Co-transplantation of stem cells with pro-survival factors can improve cell engraftment, but thi...

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Veröffentlicht in:	Nature biomedical engineering 2018-02, Vol.2 (2), p.104-113
Hauptverfasser:	Lee, Andrew S., Inayathullah, Mohammed, Lijkwan, Maarten A., Zhao, Xin, Sun, Wenchao, Park, Sujin, Hong, Wan Xing, Parekh, Mansi B., Malkovskiy, Andrey V., Lau, Edward, Qin, Xulei, Pothineni, Venkata Raveendra, Sanchez-Freire, Verónica, Zhang, Wendy Y., Kooreman, Nigel G., Ebert, Antje D., Chan, Charles K. F., Nguyen, Patricia K., Rajadas, Jayakumar, Wu, Joseph C.
Format:	Artikel
Sprache:	eng
Schlagworte:	13/100 13/107 13/51 59 59/5 59/57 639/301 639/301/54 639/301/54/990 692/4019 Animal models Biomaterials Biomedical and Life Sciences Biomedical Engineering/Biotechnology Biomedical materials Biomedicine Cell culture Cell death Cell survival Collagen Crosslinking Engraftment Extracellular matrix Injuries Peptides Regenerative medicine Stem cell transplantation Stem cells Survival Transplantation
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