Appearance of Osteonectin‐expressing Fibroblastic Cells in Early Rat Stomach Carcinogenesis and Stomach Tumors Induced with N‐Methyl‐N′‐nitro‐N‐nitrosoguanidine

The present study was designed to define molecular alterations in the initiation stage of rat stomach carcinogenesis. Groups of male Lewis rats, 6 weeks old, were given drinking water with or without N‐methyl‐N′‐nitro‐N‐nitrosoguanidine (MNNG; 100 mg/liter). Total RNA was isolated from the stomach p...

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Veröffentlicht in:	Cancer science 2002-09, Vol.93 (9), p.960-967
Hauptverfasser:	Maeng, Hack‐Young, Choi, Dong‐Kug, Takeuchi, Motoi, Yamamoto, Masami, Tominaga, Michiyo, Tsukamoto, Tetsuya, Tatematsu, Masae, Ito, Takashi, Sakaki, Yoshiyuki, Furihata, Chie
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Carcinogenesis Cell Division Collagen (type III) Differential display Drinking water Extracellular matrix Extracellular matrix protein Fibroblasts - chemistry Fibronectin Fluorescent differential display Gastric cancer Gastric Mucosa - chemistry Gene expression Immunohistochemistry Laminin Male Methylnitronitrosoguanidine MNNG Mucosa Osteonectin Osteonectin - analysis Osteonectin - genetics Osteopontin Proteoglycans Rat stomach carcinogenesis Rats Rats, Inbred Lew Rats, Inbred WKY Reverse Transcriptase Polymerase Chain Reaction Ribonucleic acid RNA Rodents Stomach Stomach Neoplasms - chemically induced Stomach Neoplasms - chemistry Stomach Neoplasms - pathology Tumors
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