Enhanced Expression of Neuron‐specific Enolase (NSE) in Pyothorax‐associated Lymphoma (PAL)
Pyothorax‐associated lymphoma (PAL) is a B‐cell lymphoma of mostly large cell type developing in the pleural cavity of patients with long‐standing pyothorax. Neuron‐specific enolase (NSE) is an enolase comprising γ subunit and is located at high levels in neuronal and neuroendocrine cells, together...
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description | Pyothorax‐associated lymphoma (PAL) is a B‐cell lymphoma of mostly large cell type developing in the pleural cavity of patients with long‐standing pyothorax. Neuron‐specific enolase (NSE) is an enolase comprising γ subunit and is located at high levels in neuronal and neuroendocrine cells, together with their neoplasias. Expression of NSE at protein and mRNA levels was examined in PAL and other types (non‐PAL) of non‐Hodgkin's lymphomas. In PAL, serum levels of NSE were elevated (5.32 to 168.0, mean 42.6 ng/ml) and tended to decrease after incisional biopsy followed by chemotherapy (2.38 to 195.5, mean 34.1 ng/ml). Two cell lines established from two cases of PAL produced and secreted NSE in the culture medium. Immunohistochemistry revealed that the positive rate for NSE staining in PAL (10 of 14 cases, 71.4%) was significantly higher than that in non‐PAL cases (6 of 38 cases, 15.8%) (P |
doi_str_mv | 10.1111/j.1349-7006.2002.tb01272.x |
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Neuron‐specific enolase (NSE) is an enolase comprising γ subunit and is located at high levels in neuronal and neuroendocrine cells, together with their neoplasias. Expression of NSE at protein and mRNA levels was examined in PAL and other types (non‐PAL) of non‐Hodgkin's lymphomas. In PAL, serum levels of NSE were elevated (5.32 to 168.0, mean 42.6 ng/ml) and tended to decrease after incisional biopsy followed by chemotherapy (2.38 to 195.5, mean 34.1 ng/ml). Two cell lines established from two cases of PAL produced and secreted NSE in the culture medium. Immunohistochemistry revealed that the positive rate for NSE staining in PAL (10 of 14 cases, 71.4%) was significantly higher than that in non‐PAL cases (6 of 38 cases, 15.8%) (P<0.01). RT‐PCR analysis showed that the expression levels of NSE mRNA in two cell lines and a biopsy sample from PAL were rather similar to those of the control samples from non‐neoplastic lymph nodes. These findings suggest the posttranscriptional regulation of NSE in PAL. Thus, an elevation of serum NSE level in patients with chronic pyothorax may be an indicator of PAL development.</description><identifier>ISSN: 0910-5050</identifier><identifier>ISSN: 1347-9032</identifier><identifier>EISSN: 1349-7006</identifier><identifier>EISSN: 1876-4673</identifier><identifier>DOI: 10.1111/j.1349-7006.2002.tb01272.x</identifier><identifier>PMID: 11985791</identifier><identifier>CODEN: GANNA2</identifier><language>eng</language><publisher>Oxford, UK: Blackwell Publishing Ltd</publisher><subject>Adolescent ; Adult ; Aged ; Biological and medical sciences ; Biopsy ; Cell culture ; Cell Line, Tumor ; Chemotherapy ; Drug Therapy ; Empyema, Pleural - metabolism ; Female ; Gene expression ; Gene Expression Regulation, Enzymologic ; Gene Expression Regulation, Neoplastic ; Hematologic and hematopoietic diseases ; Humans ; Immunohistochemistry ; Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis ; Lymph nodes ; Lymphoma ; Lymphoma - blood ; Lymphoma - enzymology ; Lymphoma, B-Cell - blood ; Lymphoma, B-Cell - enzymology ; Lymphoma, Non-Hodgkin - blood ; Lymphoma, Non-Hodgkin - enzymology ; Male ; Medical sciences ; Middle Aged ; mRNA ; Neuron‐specific enolase ; Phosphopyruvate hydratase ; Phosphopyruvate Hydratase - blood ; Pleural cavity ; Post-transcription ; Pyothorax‐associated lymphoma ; Quantitative reverse transcription PCR ; Reverse Transcriptase Polymerase Chain Reaction ; RNA - metabolism ; RNA, Messenger - metabolism ; Serum levels</subject><ispartof>Cancer science, 2002-04, Vol.93 (4), p.411-416</ispartof><rights>2002 INIST-CNRS</rights><rights>Copyright John Wiley & Sons, Inc. Apr 2002</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c5861-68936e83812264579ad6527885b9b61aeb18d69e169e2169c576cf18d67986a83</citedby><cites>FETCH-LOGICAL-c5861-68936e83812264579ad6527885b9b61aeb18d69e169e2169c576cf18d67986a83</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5927012/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5927012/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,885,1416,27923,27924,45573,45574,53790,53792</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=13877732$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/11985791$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Nakatsuka, Shin‐ichi</creatorcontrib><creatorcontrib>Nishiu, Mieko</creatorcontrib><creatorcontrib>Tomita, Yasuhiko</creatorcontrib><creatorcontrib>Miwa, Hideaki</creatorcontrib><creatorcontrib>Takakuwa, Tetsuya</creatorcontrib><creatorcontrib>Luchi, Keiji</creatorcontrib><creatorcontrib>Yamamoto, Satoru</creatorcontrib><creatorcontrib>Aozasa, Katsuyuki</creatorcontrib><title>Enhanced Expression of Neuron‐specific Enolase (NSE) in Pyothorax‐associated Lymphoma (PAL)</title><title>Cancer science</title><addtitle>Jpn J Cancer Res</addtitle><description>Pyothorax‐associated lymphoma (PAL) is a B‐cell lymphoma of mostly large cell type developing in the pleural cavity of patients with long‐standing pyothorax. Neuron‐specific enolase (NSE) is an enolase comprising γ subunit and is located at high levels in neuronal and neuroendocrine cells, together with their neoplasias. Expression of NSE at protein and mRNA levels was examined in PAL and other types (non‐PAL) of non‐Hodgkin's lymphomas. In PAL, serum levels of NSE were elevated (5.32 to 168.0, mean 42.6 ng/ml) and tended to decrease after incisional biopsy followed by chemotherapy (2.38 to 195.5, mean 34.1 ng/ml). Two cell lines established from two cases of PAL produced and secreted NSE in the culture medium. Immunohistochemistry revealed that the positive rate for NSE staining in PAL (10 of 14 cases, 71.4%) was significantly higher than that in non‐PAL cases (6 of 38 cases, 15.8%) (P<0.01). RT‐PCR analysis showed that the expression levels of NSE mRNA in two cell lines and a biopsy sample from PAL were rather similar to those of the control samples from non‐neoplastic lymph nodes. These findings suggest the posttranscriptional regulation of NSE in PAL. Thus, an elevation of serum NSE level in patients with chronic pyothorax may be an indicator of PAL development.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Aged</subject><subject>Biological and medical sciences</subject><subject>Biopsy</subject><subject>Cell culture</subject><subject>Cell Line, Tumor</subject><subject>Chemotherapy</subject><subject>Drug Therapy</subject><subject>Empyema, Pleural - metabolism</subject><subject>Female</subject><subject>Gene expression</subject><subject>Gene Expression Regulation, Enzymologic</subject><subject>Gene Expression Regulation, Neoplastic</subject><subject>Hematologic and hematopoietic diseases</subject><subject>Humans</subject><subject>Immunohistochemistry</subject><subject>Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis</subject><subject>Lymph nodes</subject><subject>Lymphoma</subject><subject>Lymphoma - blood</subject><subject>Lymphoma - enzymology</subject><subject>Lymphoma, B-Cell - blood</subject><subject>Lymphoma, B-Cell - enzymology</subject><subject>Lymphoma, Non-Hodgkin - blood</subject><subject>Lymphoma, Non-Hodgkin - enzymology</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>mRNA</subject><subject>Neuron‐specific enolase</subject><subject>Phosphopyruvate hydratase</subject><subject>Phosphopyruvate Hydratase - blood</subject><subject>Pleural cavity</subject><subject>Post-transcription</subject><subject>Pyothorax‐associated lymphoma</subject><subject>Quantitative reverse transcription PCR</subject><subject>Reverse Transcriptase Polymerase Chain Reaction</subject><subject>RNA - metabolism</subject><subject>RNA, Messenger - metabolism</subject><subject>Serum levels</subject><issn>0910-5050</issn><issn>1347-9032</issn><issn>1349-7006</issn><issn>1876-4673</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2002</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNqVkd-K1DAUxoO4uOPqK0hRlN2L1iRt_tQLYRi6qzCsC-p1SDOpk6FNukmrM3c-gs_ok2zKlh31zkByIOd3Ps45HwAvEcxQPG93GcqLMmUQ0gxDiLOhhggznO0fgcVD6jFYwBLBlEACT8HTEHYQIgYpfgJOESo5YSVaAFHZrbRKb5Jq33sdgnE2cU1yrUfv7O-fv0KvlWmMSirrWhl0cn79ubpIjE1uDm7YOi_3kZIhOGXkEHXWh67fuk4m5zfL9cUzcNLINujnczwDXy-rL6sP6frT1cfVcp0qwilKKS9zqnnOEca0iK3JDSWYcU7qsqZI6hrxDS01ihfHRxFGVTP9sZJTyfMz8P5etx_rTm-UtoOXrei96aQ_CCeN-DtjzVZ8c98FKTGL24sCb2YB725HHQbRmaB020qr3RgEQ7TgeYEi-OofcOdGb-NwAhdxxZgTTCL17p5S3oXgdfPQCoJiclHsxGSVmKwSk4tidlHsY_GLP4c5ls62ReD1DMigZNv4aKEJRy7njLEcH7fyw7T68B8tiNWyKhDK7wBobLnk</recordid><startdate>200204</startdate><enddate>200204</enddate><creator>Nakatsuka, Shin‐ichi</creator><creator>Nishiu, Mieko</creator><creator>Tomita, Yasuhiko</creator><creator>Miwa, Hideaki</creator><creator>Takakuwa, Tetsuya</creator><creator>Luchi, Keiji</creator><creator>Yamamoto, Satoru</creator><creator>Aozasa, Katsuyuki</creator><general>Blackwell Publishing Ltd</general><general>Japanese Cancer Association</general><general>John Wiley & Sons, Inc</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>8FE</scope><scope>8FH</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>LK8</scope><scope>M7P</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>200204</creationdate><title>Enhanced Expression of Neuron‐specific Enolase (NSE) in Pyothorax‐associated Lymphoma (PAL)</title><author>Nakatsuka, Shin‐ichi ; Nishiu, Mieko ; Tomita, Yasuhiko ; Miwa, Hideaki ; Takakuwa, Tetsuya ; Luchi, Keiji ; Yamamoto, Satoru ; Aozasa, Katsuyuki</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c5861-68936e83812264579ad6527885b9b61aeb18d69e169e2169c576cf18d67986a83</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2002</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Aged</topic><topic>Biological and medical sciences</topic><topic>Biopsy</topic><topic>Cell culture</topic><topic>Cell Line, Tumor</topic><topic>Chemotherapy</topic><topic>Drug Therapy</topic><topic>Empyema, Pleural - metabolism</topic><topic>Female</topic><topic>Gene expression</topic><topic>Gene Expression Regulation, Enzymologic</topic><topic>Gene Expression Regulation, Neoplastic</topic><topic>Hematologic and hematopoietic diseases</topic><topic>Humans</topic><topic>Immunohistochemistry</topic><topic>Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis</topic><topic>Lymph nodes</topic><topic>Lymphoma</topic><topic>Lymphoma - blood</topic><topic>Lymphoma - enzymology</topic><topic>Lymphoma, B-Cell - blood</topic><topic>Lymphoma, B-Cell - enzymology</topic><topic>Lymphoma, Non-Hodgkin - blood</topic><topic>Lymphoma, Non-Hodgkin - enzymology</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>mRNA</topic><topic>Neuron‐specific enolase</topic><topic>Phosphopyruvate hydratase</topic><topic>Phosphopyruvate Hydratase - blood</topic><topic>Pleural cavity</topic><topic>Post-transcription</topic><topic>Pyothorax‐associated lymphoma</topic><topic>Quantitative reverse transcription PCR</topic><topic>Reverse Transcriptase Polymerase Chain Reaction</topic><topic>RNA - metabolism</topic><topic>RNA, Messenger - metabolism</topic><topic>Serum levels</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Nakatsuka, Shin‐ichi</creatorcontrib><creatorcontrib>Nishiu, Mieko</creatorcontrib><creatorcontrib>Tomita, Yasuhiko</creatorcontrib><creatorcontrib>Miwa, Hideaki</creatorcontrib><creatorcontrib>Takakuwa, Tetsuya</creatorcontrib><creatorcontrib>Luchi, Keiji</creatorcontrib><creatorcontrib>Yamamoto, Satoru</creatorcontrib><creatorcontrib>Aozasa, Katsuyuki</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Biological Science Collection</collection><collection>Biological Science Database</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Cancer science</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Nakatsuka, Shin‐ichi</au><au>Nishiu, Mieko</au><au>Tomita, Yasuhiko</au><au>Miwa, Hideaki</au><au>Takakuwa, Tetsuya</au><au>Luchi, Keiji</au><au>Yamamoto, Satoru</au><au>Aozasa, Katsuyuki</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Enhanced Expression of Neuron‐specific Enolase (NSE) in Pyothorax‐associated Lymphoma (PAL)</atitle><jtitle>Cancer science</jtitle><addtitle>Jpn J Cancer Res</addtitle><date>2002-04</date><risdate>2002</risdate><volume>93</volume><issue>4</issue><spage>411</spage><epage>416</epage><pages>411-416</pages><issn>0910-5050</issn><issn>1347-9032</issn><eissn>1349-7006</eissn><eissn>1876-4673</eissn><coden>GANNA2</coden><abstract>Pyothorax‐associated lymphoma (PAL) is a B‐cell lymphoma of mostly large cell type developing in the pleural cavity of patients with long‐standing pyothorax. Neuron‐specific enolase (NSE) is an enolase comprising γ subunit and is located at high levels in neuronal and neuroendocrine cells, together with their neoplasias. Expression of NSE at protein and mRNA levels was examined in PAL and other types (non‐PAL) of non‐Hodgkin's lymphomas. In PAL, serum levels of NSE were elevated (5.32 to 168.0, mean 42.6 ng/ml) and tended to decrease after incisional biopsy followed by chemotherapy (2.38 to 195.5, mean 34.1 ng/ml). Two cell lines established from two cases of PAL produced and secreted NSE in the culture medium. Immunohistochemistry revealed that the positive rate for NSE staining in PAL (10 of 14 cases, 71.4%) was significantly higher than that in non‐PAL cases (6 of 38 cases, 15.8%) (P<0.01). RT‐PCR analysis showed that the expression levels of NSE mRNA in two cell lines and a biopsy sample from PAL were rather similar to those of the control samples from non‐neoplastic lymph nodes. These findings suggest the posttranscriptional regulation of NSE in PAL. Thus, an elevation of serum NSE level in patients with chronic pyothorax may be an indicator of PAL development.</abstract><cop>Oxford, UK</cop><pub>Blackwell Publishing Ltd</pub><pmid>11985791</pmid><doi>10.1111/j.1349-7006.2002.tb01272.x</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
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subjects | Adolescent Adult Aged Biological and medical sciences Biopsy Cell culture Cell Line, Tumor Chemotherapy Drug Therapy Empyema, Pleural - metabolism Female Gene expression Gene Expression Regulation, Enzymologic Gene Expression Regulation, Neoplastic Hematologic and hematopoietic diseases Humans Immunohistochemistry Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis Lymph nodes Lymphoma Lymphoma - blood Lymphoma - enzymology Lymphoma, B-Cell - blood Lymphoma, B-Cell - enzymology Lymphoma, Non-Hodgkin - blood Lymphoma, Non-Hodgkin - enzymology Male Medical sciences Middle Aged mRNA Neuron‐specific enolase Phosphopyruvate hydratase Phosphopyruvate Hydratase - blood Pleural cavity Post-transcription Pyothorax‐associated lymphoma Quantitative reverse transcription PCR Reverse Transcriptase Polymerase Chain Reaction RNA - metabolism RNA, Messenger - metabolism Serum levels |
title | Enhanced Expression of Neuron‐specific Enolase (NSE) in Pyothorax‐associated Lymphoma (PAL) |
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