Close Association between Fas Ligand (FasL; CD95L)‐positive Tumor‐associated Macrophages and Apoptotic Cancer Cells along Invasive Margin of Colorectal Carcinoma: A Proposal on Tumor‐Host Interactions

Anti‐tumor immune responses are considered to be one of the key host reactions in human colorectal cancer, with T cells as important effector cells. For the induction of tumor‐specific immunity, processing of cancer cells and pruning of T cells by antigen‐presenting cells are important. The present...

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Veröffentlicht in:	Cancer science 2002-03, Vol.93 (3), p.320-328
Hauptverfasser:	Sugita, Junichi, Ohtani, Haruo, Mizoi, Takayuki, Saito, Kazuya, Shiiba, Kenichi, Sasaki, Iwao, Matsuno, Seiki, Yagita, Hideo, Miyazawa, Masaaki, Nagura, Hiroshi
Format:	Artikel
Sprache:	eng
Schlagworte:	Aged Antigen-presenting cells Antigens, CD - immunology Antigens, CD - metabolism Antigens, Differentiation, Myelomonocytic - immunology Antigens, Differentiation, Myelomonocytic - metabolism Anti‐tumor immunity Apoptosis Apoptosis - physiology Biological and medical sciences Colorectal cancer Colorectal carcinoma Colorectal Neoplasms - metabolism Colorectal Neoplasms - pathology Cytoplasm Dendritic cells Effector cells Fas ligand Fas Ligand Protein fas Receptor - immunology fas Receptor - metabolism FasL protein Female Gastroenterology. Liver. Pancreas. Abdomen Host-tumor relations. Immunology. Biological markers Humans Hybridization Immunoenzyme Techniques Immunohistochemistry In Situ Hybridization Invasiveness Ligands Lymphocytes T Macrophage Activation - physiology Macrophages Macrophages - metabolism Male Medical sciences Membrane Glycoproteins - metabolism Metastases Microscopy, Immunoelectron Middle Aged Monoclonal antibodies mRNA Mucosa Neoplasm Invasiveness - genetics Prognosis Stomach. Duodenum. Small intestine. Colon. Rectum. Anus Stromal cells Tumors Tumor‐associated macrophages
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