Prognostic Significance of Matrix Metalloproteinase‐7 (MMP‐7) Expression at the Invasive Front in Gastric Carcinoma
To evaluate the clinicopathological significance of matrix metalloproteinase‐7 (MMP‐7) expression in gastric carcinoma, we investigated immunohistochemically MMP‐7 expression in 214 gastric carcinomas, and examined its relations with the clinicopathologic parameters including patient prognosis. MMP‐...
Gespeichert in:
| Veröffentlicht in: | Cancer science 2002-03, Vol.93 (3), p.291-295 |
|---|---|
| Hauptverfasser: | , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 295 |
|---|---|
| container_issue | 3 |
| container_start_page | 291 |
| container_title | Cancer science |
| container_volume | 93 |
| creator | Liu, Xiu Ping Kawauchi, Shigeto Oga, Atsunori Tsushimi, Kureo Tsushimi, Mutsuo Furuya, Tomoko Sasaki, Kohsuke |
| description | To evaluate the clinicopathological significance of matrix metalloproteinase‐7 (MMP‐7) expression in gastric carcinoma, we investigated immunohistochemically MMP‐7 expression in 214 gastric carcinomas, and examined its relations with the clinicopathologic parameters including patient prognosis. MMP‐7 expressed predominantly in cancer cells, and MMP‐7‐positive tumor cells were preferentially found in deeply invading nests, especially at the invasive front. The mean MMP‐7 labeling index (LI) at the invasive front was significantly higher in tumors invading or penetrating the muscularis propria and in stages II‐IV than within the submucosal layer and in stage I, respectively (P |
| doi_str_mv | 10.1111/j.1349-7006.2002.tb02171.x |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_5926963</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2399553351</sourcerecordid><originalsourceid>FETCH-LOGICAL-c6251-5751adc857a16d9b8e85e3a4fcd4fd44e1a419d2fbee91c4aabf4ba1c18c6d0a3</originalsourceid><addsrcrecordid>eNqVkdFu0zAUhiMEYt3gFZAFAsFFgk8cxzUXSFPVjUmrmARcWyeO07lK7c5Ou-5uj8Az8iQkWrQCd_jGls53fp3jL0leA82gPx9XGbBCpoLSMsspzbOuojkIyPZPkslj6WkyoRJoyimnR8lxjCtKQdAyf54cAchcUIBJcnsV_NL52FlNvtmls43V6LQhviEL7ILdk4XpsG39JvjOWIfR_Lr_Kcj7xeJqeHwg8_0mmBitdwQ70l0bcuF2GO3OkLPgXUesI-cY-yxNZhi0dX6NL5JnDbbRvBzvk-TH2fz77Et6-fX8YnZ6meoy55BywQFrPeUCoaxlNTVTbhgWja6Lpi4KA1iArPOmMkaCLhCrpqgQNEx1WVNkJ8nnh9zNtlqbWhvXBWzVJtg1hjvl0aq_K85eq6XfKS7zUpasD3g3BgR_szWxU2sbtWlbdMZvoxLAORVC9uCbf8CV3wbXL6dyJiXnjHHoqU8PlA4-xmCax1GAqsGuWqlBoRoUqsGuGu2qfd_86s9lDq2jzh54OwIYNbZN6FXaeOBYWVBg7PArt7Y1d_8xgpqdznMJ7De0CMW1</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2399553351</pqid></control><display><type>article</type><title>Prognostic Significance of Matrix Metalloproteinase‐7 (MMP‐7) Expression at the Invasive Front in Gastric Carcinoma</title><source>MEDLINE</source><source>IngentaConnect Free/Open Access Journals</source><source>Wiley Online Library Journals Frontfile Complete</source><source>Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals</source><source>PubMed Central</source><creator>Liu, Xiu Ping ; Kawauchi, Shigeto ; Oga, Atsunori ; Tsushimi, Kureo ; Tsushimi, Mutsuo ; Furuya, Tomoko ; Sasaki, Kohsuke</creator><creatorcontrib>Liu, Xiu Ping ; Kawauchi, Shigeto ; Oga, Atsunori ; Tsushimi, Kureo ; Tsushimi, Mutsuo ; Furuya, Tomoko ; Sasaki, Kohsuke</creatorcontrib><description>To evaluate the clinicopathological significance of matrix metalloproteinase‐7 (MMP‐7) expression in gastric carcinoma, we investigated immunohistochemically MMP‐7 expression in 214 gastric carcinomas, and examined its relations with the clinicopathologic parameters including patient prognosis. MMP‐7 expressed predominantly in cancer cells, and MMP‐7‐positive tumor cells were preferentially found in deeply invading nests, especially at the invasive front. The mean MMP‐7 labeling index (LI) at the invasive front was significantly higher in tumors invading or penetrating the muscularis propria and in stages II‐IV than within the submucosal layer and in stage I, respectively (P<0.001). Statistical analysis revealed that MMP‐7 LI at the invasive front was related to lymph node metastasis, vascular invasion, and lymphatic permeation, when all 214 cases were examined as one group (P<0.05 for all), and the cases with high MMP‐7 expression at the invasive front showed significantly more unfavorable prognosis as compared with that of low MMP‐7 expression tumors (P<0.01). Multivariate analysis revealed that TNM stage and MMP‐7 expression status at the invasive front were independent prognostic factors (P=0.0017, relative risk (RR)=3.12; P=0.0019, RR=2.67, respectively). Our findings indicated that expression of MMP‐7 at the invasive front is closely associated with local invasiveness, and might be a reliable prognostic marker for patients with gastric carcinoma.</description><identifier>ISSN: 0910-5050</identifier><identifier>ISSN: 1347-9032</identifier><identifier>EISSN: 1349-7006</identifier><identifier>EISSN: 1876-4673</identifier><identifier>DOI: 10.1111/j.1349-7006.2002.tb02171.x</identifier><identifier>PMID: 11927011</identifier><identifier>CODEN: GANNA2</identifier><language>eng</language><publisher>Oxford, UK: Blackwell Publishing Ltd</publisher><subject>Adult ; Aged ; Aged, 80 and over ; Biological and medical sciences ; Biomarkers, Tumor - metabolism ; Blotting, Western ; Carcinoma ; Female ; Gastric cancer ; Gastric carcinoma ; Gastroenterology. Liver. Pancreas. Abdomen ; Humans ; Immunoenzyme Techniques ; Immunohistochemistry ; Invasiveness ; Lymph nodes ; Lymphatic Metastasis ; Male ; Matrix metalloproteinase ; Matrix Metalloproteinase 7 - metabolism ; Matrix metalloproteinase‐7 (MMP‐7) ; Medical prognosis ; Medical sciences ; Metalloproteinase ; Metastases ; Middle Aged ; Multivariate analysis ; Neovascularization, Pathologic ; Prognosis ; Statistical analysis ; Stomach Neoplasms - blood supply ; Stomach Neoplasms - enzymology ; Stomach Neoplasms - pathology ; Stomach. Duodenum. Small intestine. Colon. Rectum. Anus ; Survival Rate ; Tumor cells ; Tumor Cells, Cultured ; Tumors</subject><ispartof>Cancer science, 2002-03, Vol.93 (3), p.291-295</ispartof><rights>2002 INIST-CNRS</rights><rights>Copyright John Wiley & Sons, Inc. Mar 2002</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c6251-5751adc857a16d9b8e85e3a4fcd4fd44e1a419d2fbee91c4aabf4ba1c18c6d0a3</citedby><cites>FETCH-LOGICAL-c6251-5751adc857a16d9b8e85e3a4fcd4fd44e1a419d2fbee91c4aabf4ba1c18c6d0a3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5926963/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5926963/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,881,1411,27901,27902,45550,45551,53766,53768</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=13640133$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/11927011$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Liu, Xiu Ping</creatorcontrib><creatorcontrib>Kawauchi, Shigeto</creatorcontrib><creatorcontrib>Oga, Atsunori</creatorcontrib><creatorcontrib>Tsushimi, Kureo</creatorcontrib><creatorcontrib>Tsushimi, Mutsuo</creatorcontrib><creatorcontrib>Furuya, Tomoko</creatorcontrib><creatorcontrib>Sasaki, Kohsuke</creatorcontrib><title>Prognostic Significance of Matrix Metalloproteinase‐7 (MMP‐7) Expression at the Invasive Front in Gastric Carcinoma</title><title>Cancer science</title><addtitle>Jpn J Cancer Res</addtitle><description>To evaluate the clinicopathological significance of matrix metalloproteinase‐7 (MMP‐7) expression in gastric carcinoma, we investigated immunohistochemically MMP‐7 expression in 214 gastric carcinomas, and examined its relations with the clinicopathologic parameters including patient prognosis. MMP‐7 expressed predominantly in cancer cells, and MMP‐7‐positive tumor cells were preferentially found in deeply invading nests, especially at the invasive front. The mean MMP‐7 labeling index (LI) at the invasive front was significantly higher in tumors invading or penetrating the muscularis propria and in stages II‐IV than within the submucosal layer and in stage I, respectively (P<0.001). Statistical analysis revealed that MMP‐7 LI at the invasive front was related to lymph node metastasis, vascular invasion, and lymphatic permeation, when all 214 cases were examined as one group (P<0.05 for all), and the cases with high MMP‐7 expression at the invasive front showed significantly more unfavorable prognosis as compared with that of low MMP‐7 expression tumors (P<0.01). Multivariate analysis revealed that TNM stage and MMP‐7 expression status at the invasive front were independent prognostic factors (P=0.0017, relative risk (RR)=3.12; P=0.0019, RR=2.67, respectively). Our findings indicated that expression of MMP‐7 at the invasive front is closely associated with local invasiveness, and might be a reliable prognostic marker for patients with gastric carcinoma.</description><subject>Adult</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Biological and medical sciences</subject><subject>Biomarkers, Tumor - metabolism</subject><subject>Blotting, Western</subject><subject>Carcinoma</subject><subject>Female</subject><subject>Gastric cancer</subject><subject>Gastric carcinoma</subject><subject>Gastroenterology. Liver. Pancreas. Abdomen</subject><subject>Humans</subject><subject>Immunoenzyme Techniques</subject><subject>Immunohistochemistry</subject><subject>Invasiveness</subject><subject>Lymph nodes</subject><subject>Lymphatic Metastasis</subject><subject>Male</subject><subject>Matrix metalloproteinase</subject><subject>Matrix Metalloproteinase 7 - metabolism</subject><subject>Matrix metalloproteinase‐7 (MMP‐7)</subject><subject>Medical prognosis</subject><subject>Medical sciences</subject><subject>Metalloproteinase</subject><subject>Metastases</subject><subject>Middle Aged</subject><subject>Multivariate analysis</subject><subject>Neovascularization, Pathologic</subject><subject>Prognosis</subject><subject>Statistical analysis</subject><subject>Stomach Neoplasms - blood supply</subject><subject>Stomach Neoplasms - enzymology</subject><subject>Stomach Neoplasms - pathology</subject><subject>Stomach. Duodenum. Small intestine. Colon. Rectum. Anus</subject><subject>Survival Rate</subject><subject>Tumor cells</subject><subject>Tumor Cells, Cultured</subject><subject>Tumors</subject><issn>0910-5050</issn><issn>1347-9032</issn><issn>1349-7006</issn><issn>1876-4673</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2002</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNqVkdFu0zAUhiMEYt3gFZAFAsFFgk8cxzUXSFPVjUmrmARcWyeO07lK7c5Ou-5uj8Az8iQkWrQCd_jGls53fp3jL0leA82gPx9XGbBCpoLSMsspzbOuojkIyPZPkslj6WkyoRJoyimnR8lxjCtKQdAyf54cAchcUIBJcnsV_NL52FlNvtmls43V6LQhviEL7ILdk4XpsG39JvjOWIfR_Lr_Kcj7xeJqeHwg8_0mmBitdwQ70l0bcuF2GO3OkLPgXUesI-cY-yxNZhi0dX6NL5JnDbbRvBzvk-TH2fz77Et6-fX8YnZ6meoy55BywQFrPeUCoaxlNTVTbhgWja6Lpi4KA1iArPOmMkaCLhCrpqgQNEx1WVNkJ8nnh9zNtlqbWhvXBWzVJtg1hjvl0aq_K85eq6XfKS7zUpasD3g3BgR_szWxU2sbtWlbdMZvoxLAORVC9uCbf8CV3wbXL6dyJiXnjHHoqU8PlA4-xmCax1GAqsGuWqlBoRoUqsGuGu2qfd_86s9lDq2jzh54OwIYNbZN6FXaeOBYWVBg7PArt7Y1d_8xgpqdznMJ7De0CMW1</recordid><startdate>200203</startdate><enddate>200203</enddate><creator>Liu, Xiu Ping</creator><creator>Kawauchi, Shigeto</creator><creator>Oga, Atsunori</creator><creator>Tsushimi, Kureo</creator><creator>Tsushimi, Mutsuo</creator><creator>Furuya, Tomoko</creator><creator>Sasaki, Kohsuke</creator><general>Blackwell Publishing Ltd</general><general>Japanese Cancer Association</general><general>John Wiley & Sons, Inc</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>8FE</scope><scope>8FH</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>LK8</scope><scope>M7P</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>200203</creationdate><title>Prognostic Significance of Matrix Metalloproteinase‐7 (MMP‐7) Expression at the Invasive Front in Gastric Carcinoma</title><author>Liu, Xiu Ping ; Kawauchi, Shigeto ; Oga, Atsunori ; Tsushimi, Kureo ; Tsushimi, Mutsuo ; Furuya, Tomoko ; Sasaki, Kohsuke</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c6251-5751adc857a16d9b8e85e3a4fcd4fd44e1a419d2fbee91c4aabf4ba1c18c6d0a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2002</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Biological and medical sciences</topic><topic>Biomarkers, Tumor - metabolism</topic><topic>Blotting, Western</topic><topic>Carcinoma</topic><topic>Female</topic><topic>Gastric cancer</topic><topic>Gastric carcinoma</topic><topic>Gastroenterology. Liver. Pancreas. Abdomen</topic><topic>Humans</topic><topic>Immunoenzyme Techniques</topic><topic>Immunohistochemistry</topic><topic>Invasiveness</topic><topic>Lymph nodes</topic><topic>Lymphatic Metastasis</topic><topic>Male</topic><topic>Matrix metalloproteinase</topic><topic>Matrix Metalloproteinase 7 - metabolism</topic><topic>Matrix metalloproteinase‐7 (MMP‐7)</topic><topic>Medical prognosis</topic><topic>Medical sciences</topic><topic>Metalloproteinase</topic><topic>Metastases</topic><topic>Middle Aged</topic><topic>Multivariate analysis</topic><topic>Neovascularization, Pathologic</topic><topic>Prognosis</topic><topic>Statistical analysis</topic><topic>Stomach Neoplasms - blood supply</topic><topic>Stomach Neoplasms - enzymology</topic><topic>Stomach Neoplasms - pathology</topic><topic>Stomach. Duodenum. Small intestine. Colon. Rectum. Anus</topic><topic>Survival Rate</topic><topic>Tumor cells</topic><topic>Tumor Cells, Cultured</topic><topic>Tumors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Liu, Xiu Ping</creatorcontrib><creatorcontrib>Kawauchi, Shigeto</creatorcontrib><creatorcontrib>Oga, Atsunori</creatorcontrib><creatorcontrib>Tsushimi, Kureo</creatorcontrib><creatorcontrib>Tsushimi, Mutsuo</creatorcontrib><creatorcontrib>Furuya, Tomoko</creatorcontrib><creatorcontrib>Sasaki, Kohsuke</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Biological Science Collection</collection><collection>Biological Science Database</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Cancer science</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Liu, Xiu Ping</au><au>Kawauchi, Shigeto</au><au>Oga, Atsunori</au><au>Tsushimi, Kureo</au><au>Tsushimi, Mutsuo</au><au>Furuya, Tomoko</au><au>Sasaki, Kohsuke</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Prognostic Significance of Matrix Metalloproteinase‐7 (MMP‐7) Expression at the Invasive Front in Gastric Carcinoma</atitle><jtitle>Cancer science</jtitle><addtitle>Jpn J Cancer Res</addtitle><date>2002-03</date><risdate>2002</risdate><volume>93</volume><issue>3</issue><spage>291</spage><epage>295</epage><pages>291-295</pages><issn>0910-5050</issn><issn>1347-9032</issn><eissn>1349-7006</eissn><eissn>1876-4673</eissn><coden>GANNA2</coden><abstract>To evaluate the clinicopathological significance of matrix metalloproteinase‐7 (MMP‐7) expression in gastric carcinoma, we investigated immunohistochemically MMP‐7 expression in 214 gastric carcinomas, and examined its relations with the clinicopathologic parameters including patient prognosis. MMP‐7 expressed predominantly in cancer cells, and MMP‐7‐positive tumor cells were preferentially found in deeply invading nests, especially at the invasive front. The mean MMP‐7 labeling index (LI) at the invasive front was significantly higher in tumors invading or penetrating the muscularis propria and in stages II‐IV than within the submucosal layer and in stage I, respectively (P<0.001). Statistical analysis revealed that MMP‐7 LI at the invasive front was related to lymph node metastasis, vascular invasion, and lymphatic permeation, when all 214 cases were examined as one group (P<0.05 for all), and the cases with high MMP‐7 expression at the invasive front showed significantly more unfavorable prognosis as compared with that of low MMP‐7 expression tumors (P<0.01). Multivariate analysis revealed that TNM stage and MMP‐7 expression status at the invasive front were independent prognostic factors (P=0.0017, relative risk (RR)=3.12; P=0.0019, RR=2.67, respectively). Our findings indicated that expression of MMP‐7 at the invasive front is closely associated with local invasiveness, and might be a reliable prognostic marker for patients with gastric carcinoma.</abstract><cop>Oxford, UK</cop><pub>Blackwell Publishing Ltd</pub><pmid>11927011</pmid><doi>10.1111/j.1349-7006.2002.tb02171.x</doi><tpages>5</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0910-5050 |
| ispartof | Cancer science, 2002-03, Vol.93 (3), p.291-295 |
| issn | 0910-5050 1347-9032 1349-7006 1876-4673 |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_5926963 |
| source | MEDLINE; IngentaConnect Free/Open Access Journals; Wiley Online Library Journals Frontfile Complete; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central |
| subjects | Adult Aged Aged, 80 and over Biological and medical sciences Biomarkers, Tumor - metabolism Blotting, Western Carcinoma Female Gastric cancer Gastric carcinoma Gastroenterology. Liver. Pancreas. Abdomen Humans Immunoenzyme Techniques Immunohistochemistry Invasiveness Lymph nodes Lymphatic Metastasis Male Matrix metalloproteinase Matrix Metalloproteinase 7 - metabolism Matrix metalloproteinase‐7 (MMP‐7) Medical prognosis Medical sciences Metalloproteinase Metastases Middle Aged Multivariate analysis Neovascularization, Pathologic Prognosis Statistical analysis Stomach Neoplasms - blood supply Stomach Neoplasms - enzymology Stomach Neoplasms - pathology Stomach. Duodenum. Small intestine. Colon. Rectum. Anus Survival Rate Tumor cells Tumor Cells, Cultured Tumors |
| title | Prognostic Significance of Matrix Metalloproteinase‐7 (MMP‐7) Expression at the Invasive Front in Gastric Carcinoma |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-09T06%3A35%3A25IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Prognostic%20Significance%20of%20Matrix%20Metalloproteinase%E2%80%907%20(MMP%E2%80%907)%20Expression%20at%20the%20Invasive%20Front%20in%20Gastric%20Carcinoma&rft.jtitle=Cancer%20science&rft.au=Liu,%20Xiu%20Ping&rft.date=2002-03&rft.volume=93&rft.issue=3&rft.spage=291&rft.epage=295&rft.pages=291-295&rft.issn=0910-5050&rft.eissn=1349-7006&rft.coden=GANNA2&rft_id=info:doi/10.1111/j.1349-7006.2002.tb02171.x&rft_dat=%3Cproquest_pubme%3E2399553351%3C/proquest_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2399553351&rft_id=info:pmid/11927011&rfr_iscdi=true |