PPAR-gamma agonists inhibit profibrotic phenotypes in human lung fibroblasts and bleomycin-induced pulmonary fibrosis

Pulmonary fibrosis is characterized by alterations in fibroblast phenotypes resulting in excessive extracellular matrix accumulation and anatomic remodeling. Current therapies for this condition are largely ineffective. Peroxisome proliferator-activated receptor-gamma (PPAR-gamma) is a member of the...

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Veröffentlicht in:American journal of physiology. Lung cellular and molecular physiology 2008-05, Vol.294 (5), p.L891-L901
Hauptverfasser: Milam, Jami E, Keshamouni, Venkateshwar G, Phan, Sem H, Hu, Biao, Gangireddy, Srinivasa R, Hogaboam, Cory M, Standiford, Theodore J, Thannickal, Victor J, Reddy, Raju C
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Sprache:eng
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