Increased 8‐Hydroxyguanine in DNA and Its Repair Activity in Hamster and Rat Lung after Intratracheal Instillation of Crocidolite Asbestos

Asbestos and man‐made‐mineral fibers are known to increase one type of oxidative DNA damage, 8‐hydroxyguanine (8‐OH‐Gua), in vitro. In this study, we analyzed the 8‐OH‐Gua level in DNA and its repair activity after a single intratracheal instillation of fibers (crocidolite or glass) or saline to Syr...

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Veröffentlicht in:	Cancer science 1999-05, Vol.90 (5), p.505-509
Hauptverfasser:	Yamaguchi, Raizo, Hirano, Takeshi, Ootsuyama, Yuko, Asami, Shinya, Tsurudome, Yosuke, Fukada, Shoko, Yamato, Hiroshi, Tsuda, Toru, Tanaka, Isamu, Kasai, Hiroshi
Format:	Artikel
Sprache:	eng
Schlagworte:	8‐Hydroxyguanine Animals Asbestos Asbestos, Crocidolite - toxicity Biological and medical sciences Carcinogenesis, carcinogens and anticarcinogens Carcinogenicity Carcinogens - toxicity Chemical agents Cricetinae Crocidolite Deoxyribonucleic acid DNA DNA - chemistry DNA - drug effects DNA damage DNA Repair Endonuclease Endonuclease nicking assay Enzymatic activity Fibers Glass Guanine - analogs & derivatives Guanine - analysis High-performance liquid chromatography Instillation, Drug Intubation, Intratracheal Lung - drug effects Lung - metabolism Male Medical sciences Mesocricetus Nicking endonuclease Rats Rats, Wistar Rodents Trachea Tumors
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