Bioprinting Perfusion-Enabled Liver Equivalents for Advanced Organ-on-a-Chip Applications

Many tissue models have been developed to mimic liver-specific functions for metabolic and toxin conversion in in vitro assays. Most models represent a 2D environment rather than a complex 3D structure similar to native tissue. To overcome this issue, spheroid cultures have become the gold standard...

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Veröffentlicht in:	Genes 2018-03, Vol.9 (4), p.176
Hauptverfasser:	Grix, Tobias, Ruppelt, Alicia, Thomas, Alexander, Amler, Anna-Klara, Noichl, Benjamin P, Lauster, Roland, Kloke, Lutz
Format:	Artikel
Sprache:	eng
Schlagworte:	Bile Cytochrome P450 Glucose metabolism L-Lactate dehydrogenase Lactic acid Liver Multidrug resistance Organoids Perfusion Protein transport Protein turnover Spheroids Stellate cells Tight junctions Tissue engineering
Online-Zugang:	Volltext
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