Homing in: Mechanisms of Substrate Targeting by Protein Kinases

Protein phosphorylation is the most common reversible post-translational modification in eukaryotes. Humans have over 500 protein kinases, of which more than a dozen are established targets for anticancer drugs. All kinases share a structurally similar catalytic domain, yet each one is uniquely posi...

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Veröffentlicht in:	Trends in biochemical sciences (Amsterdam. Regular ed.) 2018-05, Vol.43 (5), p.380-394
Hauptverfasser:	Miller, Chad J., Turk, Benjamin E.
Format:	Artikel
Sprache:	eng
Schlagworte:	enzyme specificity Humans linear sequence motif Phosphorylation protein interactions protein kinase Protein Kinases - chemistry Protein Kinases - metabolism protein phosphorylation Signal Transduction Substrate Specificity
Online-Zugang:	Volltext
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