Inhibiting TRK Proteins in Clinical Cancer Therapy

Gene rearrangements resulting in the aberrant activity of tyrosine kinases have been identified as drivers of oncogenesis in a variety of cancers. The tropomyosin receptor kinase (TRK) family of tyrosine receptor kinases is emerging as an important target for cancer therapeutics. The TRK family cont...

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Veröffentlicht in:	Cancers 2018-04, Vol.10 (4), p.105
Hauptverfasser:	Lange, Allison M, Lo, Hui-Wen
Format:	Artikel
Sprache:	eng
Schlagworte:	1-Phosphatidylinositol 3-kinase AKT protein Alternative splicing Breast carcinoma Cancer Cancer therapies Clinical trials Dimerization Extracellular signal-regulated kinase Glioblastoma Kinases MAP kinase Neurotrophic factors Papillary thyroid carcinoma Phosphorylation Proteins Review Thyroid Trk receptors TrkA protein TrkA receptors TrkB receptors Tropomyosin Tumorigenesis Tyrosine
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