Optimization and Evaluation of Piperacillin-Tobramycin Combination Dosage Regimens against Pseudomonas aeruginosa for Patients with Altered Pharmacokinetics via the Hollow-Fiber Infection Model and Mechanism-Based Modeling

Augmented renal clearance (ARC) in critically ill patients can result in suboptimal drug exposures and treatment failure. Combination dosage regimens accounting for ARC have never been optimized and evaluated against by use of the hollow-fiber infection model (HFIM). Using a isolate from a criticall...

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Veröffentlicht in:	Antimicrobial agents and chemotherapy 2018-05, Vol.62 (5)
Hauptverfasser:	Yadav, Rajbharan, Rogers, Kate E, Bergen, Phillip J, Bulitta, Jürgen B, Kirkpatrick, Carl M J, Wallis, Steven C, Paterson, David L, Nation, Roger L, Lipman, Jeffrey, Roberts, Jason A, Landersdorfer, Cornelia B
Format:	Artikel
Sprache:	eng
Schlagworte:	Anti-Bacterial Agents Pharmacology Piperacillin Pseudomonas aeruginosa Tobramycin
Online-Zugang:	Volltext
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