Efficacy of Human-Simulated Exposures of Ceftolozane-Tazobactam Alone and in Combination with Amikacin or Colistin against Multidrug-Resistant Pseudomonas aeruginosa in an In Vitro Pharmacodynamic Model

Combination therapy is an attractive option for the treatment of multidrug-resistant (MDR) infections; however, limited data are available on combinations with ceftolozane-tazobactam (C-T). The pharmacodynamic chemostat model was employed to compare human-simulated exposures of C-T at 3 g every 8 h...

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Veröffentlicht in:	Antimicrobial agents and chemotherapy 2018-05, Vol.62 (5)
Hauptverfasser:	Rico Caballero, Veronica, Almarzoky Abuhussain, Safa, Kuti, Joseph L, Nicolau, David P
Format:	Artikel
Sprache:	eng
Schlagworte:	Amikacin Cephalosporins Colistin Pharmacology Tazobactam
Online-Zugang:	Volltext
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