Poor perinatal growth impairs baboon aortic windkessel function
The ability of the aorta to buffer blood flow and provide diastolic perfusion (Windkessel function) is a determinant of cardiovascular health. We have reported cardiac dysfunction indicating downstream vascular abnormalities in young adult baboons who were intrauterine growth restricted (IUGR) at bi...
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| Veröffentlicht in: | Journal of developmental origins of health and disease 2018-04, Vol.9 (2), p.137-142 |
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| container_title | Journal of developmental origins of health and disease |
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| creator | Kuo, A H Li, J Li, C Huber, H F Nathanielsz, P W Clarke, G D |
| description | The ability of the aorta to buffer blood flow and provide diastolic perfusion (Windkessel function) is a determinant of cardiovascular health. We have reported cardiac dysfunction indicating downstream vascular abnormalities in young adult baboons who were intrauterine growth restricted (IUGR) at birth as a result of moderate maternal nutrient reduction. Using 3 T MRI, we examined IUGR offspring (eight male, eight female; 5.7 years; human equivalent 25 years) and age-matched controls (eight male, eight female; 5.6 years) to quantify distal descending aortic cross-section (AC) and distensibility (AD). ANOVA showed decreased IUGR AC/body surface area (0.9±0.05 cm2/m2 v. 1.2±0.06 cm2/m2, M±s.e.m., P |
| doi_str_mv | 10.1017/S2040174417000770 |
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We have reported cardiac dysfunction indicating downstream vascular abnormalities in young adult baboons who were intrauterine growth restricted (IUGR) at birth as a result of moderate maternal nutrient reduction. Using 3 T MRI, we examined IUGR offspring (eight male, eight female; 5.7 years; human equivalent 25 years) and age-matched controls (eight male, eight female; 5.6 years) to quantify distal descending aortic cross-section (AC) and distensibility (AD). ANOVA showed decreased IUGR AC/body surface area (0.9±0.05 cm2/m2 v. 1.2±0.06 cm2/m2, M±s.e.m., P<0.005) and AD (1.7±0.2 v. 4.0±0.5×10-3/mmHg, P<0.005) without sex difference or group-sex interaction, suggesting intrinsic vascular pathology and impaired development persisting in adulthood. Future studies should evaluate potential consequences of these changes on coronary perfusion, afterload and blood pressure.</description><identifier>ISSN: 2040-1744</identifier><identifier>EISSN: 2040-1752</identifier><identifier>DOI: 10.1017/S2040174417000770</identifier><identifier>PMID: 29017630</identifier><language>eng</language><publisher>England: Cambridge University Press</publisher><subject>Abdomen ; Age ; Animals ; Aorta - diagnostic imaging ; Aorta - physiopathology ; Birth weight ; Blood pressure ; Blood Pressure - physiology ; Breastfeeding & lactation ; Cardiovascular disease ; Coronary vessels ; Diet ; Female ; Fetal Growth Retardation - diagnostic imaging ; Fetal Growth Retardation - physiopathology ; Heart ; Hypertension ; Hypoxia ; Laboratory animals ; Male ; Papio ; Pregnancy ; Sheep</subject><ispartof>Journal of developmental origins of health and disease, 2018-04, Vol.9 (2), p.137-142</ispartof><rights>Cambridge University Press and the International Society for Developmental Origins of Health and Disease 2017</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c427t-94921bc86d38289e85f2e6c2ec1e87750345d17cfa773dc41262243b4f63985e3</citedby><cites>FETCH-LOGICAL-c427t-94921bc86d38289e85f2e6c2ec1e87750345d17cfa773dc41262243b4f63985e3</cites><orcidid>0000-0002-5517-7984</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>230,314,776,780,881,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/29017630$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kuo, A H</creatorcontrib><creatorcontrib>Li, J</creatorcontrib><creatorcontrib>Li, C</creatorcontrib><creatorcontrib>Huber, H F</creatorcontrib><creatorcontrib>Nathanielsz, P W</creatorcontrib><creatorcontrib>Clarke, G D</creatorcontrib><title>Poor perinatal growth impairs baboon aortic windkessel function</title><title>Journal of developmental origins of health and disease</title><addtitle>J Dev Orig Health Dis</addtitle><description>The ability of the aorta to buffer blood flow and provide diastolic perfusion (Windkessel function) is a determinant of cardiovascular health. We have reported cardiac dysfunction indicating downstream vascular abnormalities in young adult baboons who were intrauterine growth restricted (IUGR) at birth as a result of moderate maternal nutrient reduction. Using 3 T MRI, we examined IUGR offspring (eight male, eight female; 5.7 years; human equivalent 25 years) and age-matched controls (eight male, eight female; 5.6 years) to quantify distal descending aortic cross-section (AC) and distensibility (AD). ANOVA showed decreased IUGR AC/body surface area (0.9±0.05 cm2/m2 v. 1.2±0.06 cm2/m2, M±s.e.m., P<0.005) and AD (1.7±0.2 v. 4.0±0.5×10-3/mmHg, P<0.005) without sex difference or group-sex interaction, suggesting intrinsic vascular pathology and impaired development persisting in adulthood. Future studies should evaluate potential consequences of these changes on coronary perfusion, afterload and blood pressure.</description><subject>Abdomen</subject><subject>Age</subject><subject>Animals</subject><subject>Aorta - diagnostic imaging</subject><subject>Aorta - physiopathology</subject><subject>Birth weight</subject><subject>Blood pressure</subject><subject>Blood Pressure - physiology</subject><subject>Breastfeeding & lactation</subject><subject>Cardiovascular disease</subject><subject>Coronary vessels</subject><subject>Diet</subject><subject>Female</subject><subject>Fetal Growth Retardation - diagnostic imaging</subject><subject>Fetal Growth Retardation - physiopathology</subject><subject>Heart</subject><subject>Hypertension</subject><subject>Hypoxia</subject><subject>Laboratory animals</subject><subject>Male</subject><subject>Papio</subject><subject>Pregnancy</subject><subject>Sheep</subject><issn>2040-1744</issn><issn>2040-1752</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNplkUtLAzEUhYMottT-ADcy4MbNaF4zmWwUKb6goKCuQyaTaVNnkprMWPz3prQWH6t7ufnO5Z4cAI4RPEcQsYtnDGmslCIGIWQM7oHhepQiluH9XU_pAIxDWEQGEkSj5BAMMI_KnMAhuHpyzidL7Y2VnWySmXerbp6YdimND0kpS-dsIp3vjEpWxlZvOgTdJHVvVWecPQIHtWyCHm_rCLze3rxM7tPp493D5HqaKopZl3LKMSpVkVekwAXXRVZjnSusFdIFYxkkNKsQU7VkjFSKIpxjTElJ65zwItNkBC43e5d92epKadt52YilN630n8JJI36_WDMXM_chMo4xi15H4Gy7wLv3XodOtCYo3TTSatcHgXgW_6RABEb09A-6cL230Z7AGPIsZzkvIoU2lPIuBK_r3TEIinVC4l9CUXPy08VO8Z0H-QKSYYpw</recordid><startdate>20180401</startdate><enddate>20180401</enddate><creator>Kuo, A H</creator><creator>Li, J</creator><creator>Li, C</creator><creator>Huber, H F</creator><creator>Nathanielsz, P W</creator><creator>Clarke, G D</creator><general>Cambridge University Press</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0002-5517-7984</orcidid></search><sort><creationdate>20180401</creationdate><title>Poor perinatal growth impairs baboon aortic windkessel function</title><author>Kuo, A H ; Li, J ; Li, C ; Huber, H F ; Nathanielsz, P W ; Clarke, G D</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c427t-94921bc86d38289e85f2e6c2ec1e87750345d17cfa773dc41262243b4f63985e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2018</creationdate><topic>Abdomen</topic><topic>Age</topic><topic>Animals</topic><topic>Aorta - diagnostic imaging</topic><topic>Aorta - physiopathology</topic><topic>Birth weight</topic><topic>Blood pressure</topic><topic>Blood Pressure - physiology</topic><topic>Breastfeeding & lactation</topic><topic>Cardiovascular disease</topic><topic>Coronary vessels</topic><topic>Diet</topic><topic>Female</topic><topic>Fetal Growth Retardation - diagnostic imaging</topic><topic>Fetal Growth Retardation - physiopathology</topic><topic>Heart</topic><topic>Hypertension</topic><topic>Hypoxia</topic><topic>Laboratory animals</topic><topic>Male</topic><topic>Papio</topic><topic>Pregnancy</topic><topic>Sheep</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kuo, A H</creatorcontrib><creatorcontrib>Li, J</creatorcontrib><creatorcontrib>Li, C</creatorcontrib><creatorcontrib>Huber, H F</creatorcontrib><creatorcontrib>Nathanielsz, P W</creatorcontrib><creatorcontrib>Clarke, G D</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Journal of developmental origins of health and disease</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kuo, A H</au><au>Li, J</au><au>Li, C</au><au>Huber, H F</au><au>Nathanielsz, P W</au><au>Clarke, G D</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Poor perinatal growth impairs baboon aortic windkessel function</atitle><jtitle>Journal of developmental origins of health and disease</jtitle><addtitle>J Dev Orig Health Dis</addtitle><date>2018-04-01</date><risdate>2018</risdate><volume>9</volume><issue>2</issue><spage>137</spage><epage>142</epage><pages>137-142</pages><issn>2040-1744</issn><eissn>2040-1752</eissn><abstract>The ability of the aorta to buffer blood flow and provide diastolic perfusion (Windkessel function) is a determinant of cardiovascular health. We have reported cardiac dysfunction indicating downstream vascular abnormalities in young adult baboons who were intrauterine growth restricted (IUGR) at birth as a result of moderate maternal nutrient reduction. Using 3 T MRI, we examined IUGR offspring (eight male, eight female; 5.7 years; human equivalent 25 years) and age-matched controls (eight male, eight female; 5.6 years) to quantify distal descending aortic cross-section (AC) and distensibility (AD). ANOVA showed decreased IUGR AC/body surface area (0.9±0.05 cm2/m2 v. 1.2±0.06 cm2/m2, M±s.e.m., P<0.005) and AD (1.7±0.2 v. 4.0±0.5×10-3/mmHg, P<0.005) without sex difference or group-sex interaction, suggesting intrinsic vascular pathology and impaired development persisting in adulthood. 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| subjects | Abdomen Age Animals Aorta - diagnostic imaging Aorta - physiopathology Birth weight Blood pressure Blood Pressure - physiology Breastfeeding & lactation Cardiovascular disease Coronary vessels Diet Female Fetal Growth Retardation - diagnostic imaging Fetal Growth Retardation - physiopathology Heart Hypertension Hypoxia Laboratory animals Male Papio Pregnancy Sheep |
| title | Poor perinatal growth impairs baboon aortic windkessel function |
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