Mechanisms of modified LDL-induced pericyte loss and retinal injury in diabetic retinopathy

Aims/hypothesis In previous studies we have shown that extravasated, modified LDL is associated with pericyte loss, an early feature of diabetic retinopathy (DR). Here we sought to determine detailed mechanisms of this LDL-induced pericyte loss. Methods Human retinal capillary pericytes (HRCP) were...

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Veröffentlicht in:	Diabetologia 2012-11, Vol.55 (11), p.3128-3140
Hauptverfasser:	Fu, D., Wu, M., Zhang, J., Du, M., Yang, S., Hammad, S. M., Wilson, K., Chen, J., Lyons, T. J.
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetylcysteine - pharmacokinetics Acids Activating Transcription Factor 6 - metabolism Apolipoproteins B - metabolism Apoptosis Apoptosis - physiology Autophagy Autophagy - physiology Biological and medical sciences Butylamines - pharmacokinetics Cell culture Cell Survival - physiology Cells, Cultured Cyclosporine - pharmacokinetics Diabetes Diabetes. Impaired glucose tolerance Diabetic retinopathy Diabetic Retinopathy - metabolism Diabetic Retinopathy - pathology Endocrine pancreas. Apud cells (diseases) Endocrinopathies Endoplasmic reticulum Endoplasmic Reticulum Stress - physiology Enzyme Inhibitors - pharmacokinetics Etiopathogenesis. Screening. Investigations. Target tissue resistance Eye and associated structures. Visual pathways and centers. Vision Fundamental and applied biological sciences. Psychology Glucose Glycosylation Health sciences Heat-Shock Proteins - metabolism Human Physiology Humans Internal Medicine Lipid Peroxidation - physiology Lipoproteins, LDL - metabolism Lymphoma Medical sciences Medicine Medicine & Public Health Metabolic Diseases Mitochondria - metabolism Mitochondria - pathology Ophthalmology Oxidation Oxidative stress Oxidative Stress - physiology Pathogenesis Pericytes - metabolism Pericytes - pathology Poly I - pharmacokinetics Proteins Retina Retina - metabolism Retina - pathology Retinal Vessels - metabolism Retinal Vessels - pathology Retinopathies Transcription factors Vertebrates: nervous system and sense organs
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