Interferon-γ converts human microvascular pericytes into negative regulators of alloimmunity through induction of indoleamine 2,3-dioxygenase 1

Early acute rejection of human allografts is mediated by circulating alloreactive host effector memory T cells (TEM). TEM infiltration typically occurs across graft postcapillary venules and involves sequential interactions with graft-derived endothelial cells (ECs) and pericytes (PCs). While the ro...

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Veröffentlicht in:	JCI insight 2018-03, Vol.3 (5)
Hauptverfasser:	Liu, Rebecca, Merola, Jonathan, Manes, Thomas D, Qin, Lingfeng, Tietjen, Gregory T, López-Giráldez, Francesc, Broecker, Verena, Fang, Caodi, Xie, Catherine, Chen, Ping-Min, Kirkiles-Smith, Nancy C, Jane-Wit, Dan, Pober, Jordan S
Format:	Artikel
Sprache:	eng
Schlagworte:	Allografts - blood supply Allografts - cytology Allografts - immunology Animals Antigen Presentation - immunology Cell Communication - immunology Cells, Cultured Disease Models, Animal Endothelial Cells - immunology Endothelium, Vascular - cytology Female Graft Rejection - immunology Healthy Volunteers Human Umbilical Vein Endothelial Cells Humans Indoleamine-Pyrrole 2,3,-Dioxygenase - genetics Indoleamine-Pyrrole 2,3,-Dioxygenase - immunology Indoleamine-Pyrrole 2,3,-Dioxygenase - metabolism Interferon-gamma - immunology Interferon-gamma - metabolism Isoantigens - immunology Mice, SCID Microvessels - cytology Microvessels - immunology Pericytes - immunology Pericytes - metabolism Primary Cell Culture RNA, Small Interfering - metabolism Skin - blood supply Skin - cytology Skin - immunology Skin Transplantation - adverse effects T-Lymphocytes, Cytotoxic - immunology T-Lymphocytes, Cytotoxic - metabolism Transplantation Chimera Transplantation, Homologous - adverse effects Tryptophan - metabolism
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