Association Between Midlife Vascular Risk Factors and Estimated Brain Amyloid Deposition

IMPORTANCE: Midlife vascular risk factors have been associated with late-life dementia. Whether these risk factors directly contribute to brain amyloid deposition is less well understood. OBJECTIVE: To determine if midlife vascular risk factors are associated with late-life brain amyloid deposition,...

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Veröffentlicht in:	JAMA : the journal of the American Medical Association 2017-04, Vol.317 (14), p.1443-1450
Hauptverfasser:	Gottesman, Rebecca F, Schneider, Andrea L. C, Zhou, Yun, Coresh, Josef, Green, Edward, Gupta, Naresh, Knopman, David S, Mintz, Akiva, Rahmim, Arman, Sharrett, A. Richey, Wagenknecht, Lynne E, Wong, Dean F, Mosley, Thomas H
Format:	Artikel
Sprache:	eng
Schlagworte:	Age Factors Aged Aged, 80 and over Alleles Alzheimer Disease - genetics Amyloid - metabolism Aniline Compounds - pharmacokinetics Apolipoproteins E - genetics Atherosclerosis Black People Body Mass Index Brain - diagnostic imaging Brain - metabolism Dementia Dementia - etiology Diabetes Complications Ethylene Glycols - pharmacokinetics Female Fluorine Radioisotopes - pharmacokinetics Follow-Up Studies Humans Hypercholesterolemia - complications Hypertension - complications Male Middle age Middle Aged Odds Ratio Positron-Emission Tomography - methods Prospective Studies Risk Factors Smoking - adverse effects Time Factors Vein & artery diseases White People
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