Different Effects of FK317 on Multidrug‐resistant Tumor in vivo and in vitro

FK317, a novel substituted dihydrobenzoxazine, was examined for antitumor effects on multidrug‐resistant (MDR) tumor cells in vitro and in vivo. In nude mice, FK317 markedly inhibited the growth of s.c. implanted KB‐V1 vinblastine (VLB)‐resistant human epidermal carcinoma KB cells, as well as the pa...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Cancer science 1998-10, Vol.89 (10), p.1047-1054
Hauptverfasser:	Naoe, Yoshinori, Inami, Masamichi, Takagaki, Shoji, Matsumoto, Sanae, Kawamura, Ikuo, Nishigaki, Fusako, Tsujimoto, Susumu, Manda, Toshitaka, Shimomura, Kyoichi
Format:	Artikel
Sprache:	eng
Schlagworte:	Affinity Labels Animals Antineoplastic agents Antineoplastic Agents - pharmacokinetics Antineoplastic Agents - therapeutic use Antineoplastic Agents - toxicity Antitumor activity Antitumor effect ATP Binding Cassette Transporter, Subfamily B, Member 1 - metabolism Azides - pharmacokinetics Biological and medical sciences Biotransformation Carcinoma, Small Cell - drug therapy Carcinoma, Small Cell - pathology Cell Survival - drug effects Chemotherapy Cytotoxicity Deacetyl metabolite Dihydropyridines - pharmacokinetics Drug Resistance, Multiple FK317 Glycoproteins Humans KB Cells Lung carcinoma Lung Neoplasms - drug therapy Lung Neoplasms - pathology Male MDR Medical sciences Metabolites Mice Mice, Nude Nasopharyngeal Neoplasms - drug therapy Nasopharyngeal Neoplasms - pathology Oxazines - pharmacokinetics Oxazines - therapeutic use Oxazines - toxicity Pharmacology. Drug treatments P‐Glycoprotein Transplantation, Heterologous Tritium Tumor cells Verapamil Vinblastine Vinblastine - toxicity
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!